Center for Molecular Medicine Cologne

Esther von Stebut-Borschitz - assoc. RG

Skin immune defense mechanisms against cutaneous leishmaniasis


Our lab focuses on studying the immune defense mechanisms against murine and human cutaneous leishmaniasis, initiated by infections with the protozoan parasite Leishmania major (L. major). Current projects concentrate on studying the DC subtypes involved in defense mechanisms, the interaction of DC with T cells (antigens recognized, T cell subsets involved), and the role of additional myeloid cells for immune regulation (mast cells, monocytes/macrophages). Finally, using so-called 'humanized mouse models', translation of basic research findings into the clinical setting is central. Understanding the details of immunity against the parasite will aid not only basic research in skin immunity against various pathogens and in chronic inflammatory processes, but will also aid the development of a vaccine against this important human pathogen.

Clinical/medical relevance and sustainability in disease understanding

Leishmaniasis is among the top then most frequent infectious diseases worldwide with ~12 Mio. infected individuals. The parasite is endemic in (sub)tropical regions on the globe and is transmitted by the bite of a sand fly. Disease manifestation ranges from cutaneous, limited disease, to disseminated, recurrent forms and finally to visceral leishmaniasis. Untreated, the latter is life threatening. Treatment options range from antimons, liposomal amphotericin B, and miltefosine, to topical treatment, some of which have severe side effects. A vaccine is not yet available, even though T cell-mediated memory responses protect against re-infection with the same parasite subspecies.

Former Funding Period 01/2017 - 12/2019

Information from this funding period will not be updated anymore. New research related information is available here.

CMMC Funding Period 1/2020-12/2022

Esther von Stebut-Borschitz | Nir Yogev - B 08

The role of antigen-presenting cell subtypes in anti-Leishmania immunity

Prof. Dr. Esther von Stebut-Borschitz CMMC Cologne
Prof. Dr. Esther von Stebut-Borschitz

Clinic and Polyclinic of Dermatology and Venereology

CMMC - PI -  B 08

+49 221 478 4500

+49 221 478 86465

Clinic and Polyclinic of Dermatology and Venereology

Kerpener Str. 62

50937 Cologne

CMMC Profile Page

Curriculum Vitae (CV)

Publications on PubMed

Publications - Esther von Stebut-Borschitz

Link to PubMed