Center for Molecular Medicine Cologne

Nguyen, Phuong-Hien - CAP 19

Deciphering the functional relevance and signal transduction network of protein kinases in the tumor microenvironment

Introduction

The definition of cancer hallmarks has significantly expanded in the last decades and cancer is no longer considered a disease of only malignant cells, but a highly complex tissue comprising tumor cells and their tumor microenvironment (TME). “My research is based on the finding that non-receptor tyrosine kinases are functionally essential for the creation of a proneoplastic, microenvironmental niche. The distinct, cell-type specific patterns of substrate activation induced by kinases may lead to a differential activation of transcription factors and, as a consequence, to a cell type-specific modulation of cellular functions”, Nguyen comments and adds ”Because many kinase inhibitors are readily available, understanding these kinases’ functions in the TME will be useful to design improved anti-cancer therapies, particularly to target the immune- and metastatic niches”.

  1. Nguyen P.H.*, Niesen E.*, and Hallek M.: New roles for B cell receptor associated kinases: when the B cell is not the target. Leukemia 2019 Mar; 33(3):576-587
     
  2. Nguyen, P.H., Fedorchenko, O., Rosen, N., Koch, M., Barthel, R., Winarski, T., Florin, A., Wunderlich, F.T., Reinart, N., and Hallek, M. (2016). LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia. Cancer Cell 30, 610-622.
     
  3. Reinart, N., Nguyen, P.H., Boucas, J., Rosen, N., Kvasnicka, H.M., Heukamp, L., Rudolph, C., Ristovska, V., Velmans, T., Mueller, C., Reiners, K.S., von Strandmann, E.P., Krause, G., Montesinos-Rongen, M., Schlegelberger, B., Herling, M., Hallek, M., and Fingerle-Rowson, G. (2013). Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor. Blood  121, 812-821.

Barthel R, Fedorchenko O, Velmans T, Rosen N, Nguyen PH, Reinart N, Florin A, Herling M, Hallek M, Fingerle-Rowson G.: CD74 is dispensable for development of chronic lymphocytic leukemia in Eµ-TCL1 transgenic mice. Leuk Lymphoma. 2020 Jul 15:1-12. doi: 10.1080/10428194.2020.1791851. Online ahead of print. PMID: 32667245

Koch M, Reinartz S, Saggau J, Knittel G, Rosen N, Fedorchenko O, Thelen L, Barthel R, Reinart N, Seeger-Nukpezah T, Reinhardt HC, Hallek M, Nguyen PH.: Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Eµ-TCL1 Transgenic Mouse Model.

 

Dr. Phuong-Hien Nguyen CMMC Cologne
Dr. Phuong-Hien Nguyen

Clinic I for Internal Medicine

CMMC - PI - CAP 19

CMMC - Co-PI - A 04

Publications - Phuong-Hien Nguyen

Link to PubMed