Center for Molecular Medicine Cologne

Pallasch, Christian P | Heidenreich, Axel | Nestler, Tim - assoc. RG 15

Exploiting tumor heterogeneity and tumor microenvironment interactions in Testicular Germ Cell Tumors (TGCT) impacting metastasis and therapy response

Abstract

Tumor heterogeneity may account for Invasion and metastasis testicular germ cell tumors. In our previous work we have identified predictive signatures for metastasis as well as immune regulatory networks such as IL6 signalling differentially expressed on the invasive front of seminomas. Here we will further approach the heterogenous composition of the germ cell tumor microenvironment in an interdisciplinary research project which will combine spatial and whole genome assessments in TGCT for evaluation of metastatic disease and to exploit its mechanisms for therapeutic approaches.

Clinical and Medical Relevance

Tumor heterogeneity is a major challenge in cancer therapy accounting for development of resistance. In testicular germ cell tumors (TGCT), the majority of patients show good response to chemotherapy, but patients facing resistance still have a poor prognosis. Chemo-refractory disease remains an obstacle that cannot be overcome with targeted or immune therapy.

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Prof. Dr. Christian P Pallasch CMMC Cologne
Prof. Dr. Christian P Pallasch

Clinic I of Internal Medicine

CMMC - PI - assoc. RG 15

 

+49 221 478 84128

+49 221 478 97295

Clinic I of Internal Medicine

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50937 Cologne

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Prof. Dr. Axel Heidenreich CMMC Cologne
Prof. Dr. Axel Heidenreich

Clinic and Polyclinic of Urology and Uro-Oncology

CMMC - Co-PI - assoc. RG 15

+49 221 478 82108

+49 221 478 86465

Clinic and Polyclinic of Urology and Uro-Oncology

Kerpener Str. 62

50937 Cologne

https://urologie.uk-koeln.de/informationen/ansprechpartner-auf-einen-blick/

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PD Dr. Tim Nestler CMMC Cologne
PD Dr. Tim Nestler

Clinic and Polyclinic of Urology and Uro-Oncology

CMMC - Co-PI - assoc. RG 15

+49 221 478 76747

Clinic and Polyclinic of Urology and Uro-Oncology

Kerpener Str. 62

50937 Cologne

CMMC Profile Page

Curriculum Vitae (CV)

Publications on PubMed

Publications - Tim Nestler

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