Center for Molecular Medicine Cologne

Summary of articles published by CMMC members in 2021

Original Articles and Reviews with CMMC affiliation listed in alphabetical order by the first author published in 2021.

  • Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Adão R, Vasques-Nóvoa F, Freundt J K, Voglhuber  J, Pricolo M R, Kasa M, Türk C, Aprahamian F, Herrero-Galán E, Hofer S J, Pendl T, Rech L, Kargl J, Anto-Michel N, Ljubojevic-Holzer S, Schipke J, Brandenberger C, Auer M, Schreiber R, Koyani C N, Heinemann A, Zirlik A, Schmidt A, von Lewinski D, Scherr D, Rainer P P, von Maltzahn J, Mühlfeld C, KrügerM, Frank S, Madeo F, Eisenberg T, Prokesch A, Leite-Moreira A F, Lourenço A P, Alegre-Cebollada J, Kiechl S, Linke W A, Kroemer G, Sedej S (2021). Nicotinamide for the treatment of heart failure with preserved ejection fraction. Sci Transl Med. 13(580), eabd7064.
  • Affeldt P, Di Cristanziano V, Grundmann F, Wirtz M, Kaiser R, Benzing T, Stippel D, Kann M & Kurschat C (2021) Monitoring of hepatitis E virus RNA during treatment for chronic hepatitis E virus infection after renal transplantation. Immun Inflamm Dis 9, 513–520.
  • Akasaka E, Kleiser S, Sengle G, Bruckner-Tuderman L, Nyström A (2021). Diversity of Mechanisms Underlying Latent TGF-β Activation in Recessive Dystrophic Epidermolysis Bullosa. J Invest Dermatol141, 1450-1460.e9. doi: 10.1016/j.jid.2020.10.024.
  • Altman T, Ionescu A, Ibraheem A, Priesmann D, Gradus-Pery T, Farberov L, Alexandra G, Shelestovich N, Dafinca R, Shomron N, Rage F, Talbot K, Ward M E, Dori A, Krüger M, Perlson E (2021). Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins. Nat Commun. 12(1), 6914.
  • Aravamudhan S, Turk C, Bock T, Keufgens L, Nolte H, Lang F, Krishnan RK, Konig T, Hammerschmidt P, Schindler N, Brodesser S, Rozsivalova DH, Rugarli E,Trifunovic A, Bruning J, Langer T, Braun T, and Kruger M (2021). Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. J Mol Cell Cardiol154, 41-59. doi:10.1016/j.yjmcc.2021.01.010.
  • Arolt C, Hoffmann F, Nachtsheim L, Wolber P, Guntinas-Lichius O, Buettner R, von Eggeling F, Quaas A, and Klussmann JP (2021). Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort. Head Neck Pathol. doi:10.1007/s12105-021-01370-0.
  • Asif M, Mocanu ID, Abdullah U, Hohne W, Altmuller J, Makhdoom EUH, Thiele H, Baig SM, Nurnberg P, Graul-Neumann L, and Hussain MS (2021). A novel missense variant of SCN4A co-segregates with congenital essential tremor in a consanguineous Kurdish family. Am J Med Genet A. doi:10.1002/ajmg.a.62610.
  • Bachmann S, Bell M, Klimek J, and Zempel H (2021). Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU. Front Neurosci15, 643115. doi:10.3389/fnins.2021.643115.
  • Bachmann S, Linde J, Bell M, Spehr M, Zempel H, and Zimmer-Bensch G (2021). DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons. Int J Mol Sci22. doi:10.3390/ijms22042034.
  • Bamborschke D, Ozdemir O, Kreutzer M, Motameny S, Thiele H, Kribs A, Dotsch J, Altmuller J, Nurnberg P, and Cirak S (2021). Ultra-rapid emergency genomic diagnosis of Donahue syndrome in a preterm infant within 17 hours. Am J Med Genet A185, 90-96. doi:10.1002/ajmg.a.61917.
  • Banck JC, Mueller N, Mellinghoff SC, Thelen M, Fraccaroli A, Blumenberg V, Koehler P, Kunz WG, Rudelius M, Schrotzlmair F, Subklewe M, Schlosser HA, Tischer J, Cornely OA, Lindner LH, and von Bergwelt-Baildon M (2021). Immune Checkpoint Blockade for Aspergillosis and Mucormycosis Coinfection. Hemasphere5, e530. doi:10.1097/HS9.0000000000000530.
  • Baraldo M, Nogara L, Dumitras GA, Tchampda Dondjang AH, Geremia A, Scalabrin M, Turk C, Telkamp F, Zentilin L, Giacca M, Kruger M, and Blaauw B (2021). Raptor is critical for increasing the mitochondrial proteome and skeletal muscle force during hypertrophy. FASEB J35, e22031. doi:10.1096/fj.202101054RR.
  • Barnes DR, Silvestri V, Leslie G, McGuffog L, Dennis J, Yang X, Adlard J, Agnarsson BA, Ahmed M, Aittomaki K, Andrulis IL, Arason A, Arnold N, Auber B, Azzollini J, Balmana J, Barkardottir RB, Barrowdale D, Barwell J, Belotti M, Benitez J, Berthet P, Boonen SE, Borg A, Bozsik A, Brady A, Brennan P, Brewer C, Brunet J, Bucalo A, Buys SS, Caldes T, Caligo MA, Campbell I, Cassingham H, Lotte Christensen L, Cini G, Claes KBM, Collaborators GS, Collaborators E, Cook J, Coppa A, Cortesi L, Damante G, Darder E, Davidson R, de la Hoya M, De Leeneer K, de Putter R, Del Valle J, Diez O, Chun Ding Y, Domchek SM, Donaldson A, Eason J, Eeles R, Engel C, Gareth Evans D, Feliubadalo L, Fostira F, Frone M, Frost D, Gallagher D, Gehrig A, Giraud S, Glendon G, Godwin AK, Goldgar DE, Greene MH, Gregory H, Gross E, Hahnen E, Hamann U, Hansen TVO, Hanson H, Hentschel J, Horvath J, Investigators KC, Investigators H, Izatt L, Izquierdo A, James PA, Janavicius R, Birk Jensen U, Johannsson OT, John EM, Kramer G, Kroeldrup L, Kruse TA, Lautrup C, Lazaro C, Lesueur F, Lopez-Fernandez A, Mai PL, Manoukian S, Matrai Z, Matricardi L, Maxwell KN, Mebirouk N, Meindl A, Montagna M, Monteiro AN, Morrison PJ, Muranen TA, Murray A, Nathanson KL, Neuhausen SL, Nevanlinna H, Nguyen-Dumont T, Niederacher D, Olah E, Olopade OI, Palli D, Parsons MT, Sokilde Pedersen I, Peissel B, Perez-Segura P, Peterlongo P, Petersen AH, Pinto P, Porteous ME, Pottinger C, Angel Pujana M, Radice P, Ramser J, Rantala J, Robson M, Rogers MT, Ronlund K, Rump A, Maria Sanchez de Abajo A, Shah PD, Sharif S, Side LE, Singer CF, Stadler Z, Steele L, Stoppa-Lyonnet D, Sutter C, Yen Tan Y, Teixeira MR, Teule A, Thull DL, Tischkowitz M, Toland AE, Tommasi S, Toss A, Trainer AH, Tripathi V, Valentini V, van Asperen CJ, Venturelli M, Viel A, Vijai J, Walker L, Wang-Gohrke S, Wappenschmidt B, Whaite A, Zanna I, Offit K, Thomassen M, Couch FJ, Schmutzler RK, Simard J, Easton DF, Chenevix-Trench G, Antoniou AC, Ottini L, Consortium of Investigators of Modifiers of B, and Brca (2021). Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores. J Natl Cancer Inst. doi:10.1093/jnci/djab147.
  • Baxter JS, Johnson N, Tomczyk K, Gillespie A, Maguire S, Brough R, Fachal L, Michailidou K, Bolla MK, Wang Q, Dennis J, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SE, Brenner H, Brucker SY, Cai Q, Campa D, Canzian F, Castelao JE, Chan TL, Chang-Claude J, Chanock SJ, Chenevix-Trench G, Choi JY, Clarke CL, Collaborators N, Colonna S, Conroy DM, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dork T, Dossus L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Engel C, Fasching PA, Figueroa J, Flyger H, Gago-Dominguez M, Gao C, Garcia-Closas M, Garcia-Saenz JA, Ghoussaini M, Giles GG, Goldberg MS, Gonzalez-Neira A, Guenel P, Gundert M, Haeberle L, Hahnen E, Haiman CA, Hall P, Hamann U, Hartman M, Hatse S, Hauke J, Hollestelle A, Hoppe R, Hopper JL, Hou MF, kConFab I, Investigators A, Ito H, Iwasaki M, Jager A, Jakubowska A, Janni W, John EM, Joseph V, Jung A, Kaaks R, Kang D, Keeman R, Khusnutdinova E, Kim SW, Kosma VM, Kraft P, Kristensen VN, Kubelka-Sabit K, Kurian AW, Kwong A, Lacey JV, Lambrechts D, Larson NL, Larsson SC, Le Marchand L, Lejbkowicz F, Li J, Long J, Lophatananon A, Lubinski J, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Matsuo K, Mavroudis D, Mayes R, Menon U, Milne RL, Mohd Taib NA, Muir K, Muranen TA, Murphy RA, Nevanlinna H, O'Brien KM, Offit K, Olson JE, Olsson H, Park SK, Park-Simon TW, Patel AV, Peterlongo P, Peto J, Plaseska-Karanfilska D, Presneau N, Pylkas K, Rack B, Rennert G, Romero A, Ruebner M, Rudiger T, Saloustros E, Sandler DP, Sawyer EJ, Schmidt MK, Schmutzler RK, Schneeweiss A, Schoemaker MJ, Shah M, Shen CY, Shu XO, Simard J, Southey MC, Stone J, Surowy H, Swerdlow AJ, Tamimi RM, Tapper WJ, Taylor JA, Teo SH, Teras LR, Terry MB, Toland AE, Tomlinson I, Truong T, Tseng CC, Untch M, Vachon CM, van den Ouweland AMW, Wang SS, Weinberg CR, Wendt C, Winham SJ, Winqvist R, Wolk A, Wu AH, Yamaji T, Zheng W, Ziogas A, Pharoah PDP, Dunning AM, Easton DF, Pettitt SJ, Lord CJ, Haider S, Orr N, and Fletcher O (2021). Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element. Am J Hum Genet108, 1190-1203. doi:10.1016/j.ajhg.2021.05.013.
  • Bebber CM, Thomas ES, Stroh J, Chen Z, Androulidaki A, Schmitt A, Hohne MN, Stuker L, de Padua Alves C, Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J, George J, Brodesser S, Thomas RK, Reinhardt HC, and von Karstedt S (2021). Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun12, 2048. doi:10.1038/s41467-021-22336-4.
  • Bell M, and Zempel H (2021). SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability. Rev Neurosci. doi:10.1515/revneuro-2020-0152.
  • Berghausen EM, Janssen W, Vantler M, Gnatzy-Feik LL, Krause M, Behringer A, Joseph C, Zierden M, Freyhaus HT, Klinke A, Baldus S, Alcazar MA, Savai R, Pullamsetti SS, Wong DW, Boor P, Zhao JJ, Schermuly RT, and Rosenkranz S (2021). Disrupted PI3K subunit p110alpha signaling protects against pulmonary hypertension and reverses established disease in rodents. J Clin Invest131. doi:10.1172/JCI136939.
  • Berthold F, Ernst A, Ackermann S, Bartenhagen C, Christiansen H, Hero B, Rosswog C, von Schweinitz D, Klingebiel T, Schmid I, Simon T, and Fischer M (2021). Genetic Alterations and Resectability Predict Outcome in Patients with Neuroblastoma Assigned to High-Risk Solely by MYCN Amplification. Cancers (Basel)13. doi:10.3390/cancers13174360.
  • Berthold F, Rosswog C, Christiansen H, Frühwald M, Hemstedt N, Klingebiel T, Fröhlich B, Schilling FH, Schmid I, Simon T, Hero B, Fischer M, Ernst A (2021). Clinical and molecular characterization of patients with stage 4(M) neuroblastoma aged less than 18 months without MYCN amplification. Pediatr Blood Cancer 68(8): e29038. doi: 10.1002/pbc.29038.
  • Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klockener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, and Bruning JC (2021). Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci24, 913-929. doi:10.1038/s41593-021-00854-0.
  • Birtel J, Spital G, Book M, Habbig S, Baumner S, Riehmer V, Beck BB, Rosenkranz D, Bolz HJ, Dahmer-Heath M, Herrmann P, Konig J, and Charbel Issa P (2021). NPHP1 gene-associated nephronophthisis is associated with an occult retinopathy. Kidney Int100, 1092-1100. doi:10.1016/j.kint.2021.06.012.
  • Bleckwehl T, Crispatzu G, Schaaf K, Respuela P, Bartusel M, Benson L, Clark SJ, Dorighi KM, Barral A, Laugsch M, van IWFJ, Manzanares M, Wysocka J, Reik W, and Rada-Iglesias A (2021). Enhancer-associated H3K4 methylation safeguards in vitro germline competence. Nat Commun12, 5771. doi:10.1038/s41467-021-26065-6.
  • Bock T, Turk C, Aravamudhan S, Keufgens L, Bloch W, Rozsivalova DH, Romanello V, Nogara L, Blaauw B, Trifunovic A, Braun T, and Kruger M (2021). PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B. Nat Commun12, 4900. doi:10.1038/s41467-021-25185-3.
  • Boehm V, Kueckelmann S, Gerbracht JV, Kallabis S, Britto-Borges T, Altmuller J, Kruger M, Dieterich C, and Gehring NH (2021). SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity. Nat Commun12, 3965. doi:10.1038/s41467-021-24046-3.
  • Borgmann D, Ciglieri E, Biglari N, Brandt C, Cremer AL, Backes H, Tittgemeyer M, Wunderlich FT, Bruning JC, and Fenselau H (2021). Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab33, 1466-1482 e1467. doi:10.1016/j.cmet.2021.05.002.
  • Bottcher M, Bruns H, Volkl S, Lu J, Chartomatsidou E, Papakonstantinou N, Mentz K, Buttner-Herold M, Zenz T, Herling M, Huber W, Ghia P, Stamatopoulos K, Mackensen A, and Mougiakakos D (2021). Control of PD-L1 expression in CLL-cells by stromal triggering of the Notch-c-Myc-EZH2 oncogenic signaling axis. J Immunother Cancer9. doi:10.1136/jitc-2020-001889.
  • Bozadjieva-Kramer N, Ross RA, Johnson DQ, Fenselau H, Haggerty DL, Atwood B, Lowell B, and Flak JN (2021). The Role of Mediobasal Hypothalamic PACAP in the Control of Body Weight and Metabolism. Endocrinology162. doi:10.1210/endocr/bqab012.
  • Bozek K, Hebert L, Portugal Y, Mikheyev AS, and Stephens GJ (2021). Markerless tracking of an entire honey bee colony. Nat Commun12, 1733. doi:10.1038/s41467-021-21769-1.
  • Bragelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, Dammert MA, Plenker D, Klein S, Lohneis P, Gu J, Godfrey LK, Forster J, Trajkovic-Arsic M, Zillinger T, Haarmann M, Quaas A, Lennartz S, Schmiel M, D'Rozario J, Thomas ES, Li H, Schmitt CA, George J, Thomas RK, von Karstedt S, Hartmann G, Buttner R,Ullrich RT, Siveke JT, Ohashi K, Schlee M, and Sos ML (2021). MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I. Nat Commun12, 5505. doi:10.1038/s41467-021-25728-8.
  • Braumann S, Schumacher W, Im NG, Nettersheim FS, Mehrkens D, Bokredenghel S, Hof A, Nies RJ, Adler C, Winkels H, Knoll R, Freeman BA, Rudolph V, Klinke A, Adam M, Baldus S, Mollenhauer M, and Geissen S (2021). Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis. Int J Mol Sci22. doi:10.3390/ijms22169052.
  • Breuer S, Kasper P, Vohlen C, Janoschek R, Hoffmann T, Appel S, Muller-Limberger E, Mesaros A, Rose-John S, Garbers C, Muller S, Lackmann JW, Mahabir E, Dotsch J, Hucklenbruch-Rother E, and Bae-Gartz I (2021). Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring. Nutrients13. doi:10.3390/nu13113735.
  • Brinkmann J, Zeissler EC, Scharrenberg JS, Schenk J, Majjouti M, Oberste M, Yagdiran A, Scheyerer MJ, Jung N, Siewe J, and Mahabir E (2021). The diagnostic value of cytokines for the discrimination of vertebral osteomyelitis and degenerative diseases of the spine. Cytokine150, 155782. doi:10.1016/j.cyto.2021.155782.
  • Buettner JM, Sime Longang JK, Gerstner F, Apel KS, Blanco-Redondo B, Sowoidnich L, Janzen E, Langenhan T, Wirth B, and Simon CM (2021). Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models. iScience24, 103376. doi:10.1016/j.isci.2021.103376.
  • Burgmaier K, Brinker L, Erger F, Beck BB, Benz MR, Bergmann C, Boyer O, Collard L, Dafinger C, Fila M, Kowalewska C, Lange-Sperandio B, Massella L, Mastrangelo A, Mekahli D, Miklaszewska M, Ortiz-Bruechle N, Patzer L, Prikhodina L, Ranchin B, Ranguelov N, Schild R, Seeman T, Sever L, Sikora P, Szczepanska M, Teixeira A, Thumfart J, Uetz B, Weber LT, Wühl E, Zerres K; ESCAPE Study group; GPN study group, Dötsch J, Schaefer F, Liebau MC; ARegPKD consortium. Refining genotype-phenotype correlations in 304 patients with autosomal recessive polycystic kidney disease and PKHD1 gene variants. Kidney Int. 2021 Sep;100(3):650-659. doi: 10.1016/j.kint.2021.04.019
  • Butt L, Unnersjo-Jess D, Hohne M, Hahnfeldt R, Reilly D, Rinschen MM, Plagmann I, Diefenhardt P, Brahler S, Brinkkotter PT, Brismar H, Blom H, Schermer B, and Benzing T (2022). Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease. J Am Soc Nephrol33, 138-154. doi:10.1681/ASN.2020060858.
  • Butt L, Unnersjo-Jess D, Hohne M, Schermer B, Edwards A, and Benzing T (2021). A mathematical estimation of the physical forces driving podocyte detachment. Kidney Int100, 1054-1062. doi:10.1016/j.kint.2021.06.040.
  • Calculli G, Lee HJ, Shen K, Pham U, Herholz M, Trifunovic A, Dillin A, and Vilchez D (2021). Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans. Sci Adv7. doi:10.1126/sciadv.abg3012.
  • Cappelletti V, Hauser T, Piazza I, Pepelnjak M, Malinovska L, Fuhrer T, Li Y, Dorig C, Boersema P, Gillet L, Grossbach J, Dugourd A, Saez-Rodriguez J, Beyer A, Zamboni N, Caflisch A, de Souza N, and Picotti P (2021). Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ. Cell184(2), 545-559 e22. doi:10.1016/j.cell.2020.12.021.
  • Charmpi K, Chokkalingam M, Johnen R, and Beyer A (2021). Optimizing network propagation for multi-omics data integration. PLoS Comput Biol17(11), e1009161. doi:10.1371/journal.pcbi.1009161.
  • Chen J, Nelson C, Wong M, Tee AE, Liu PY, La T, Fletcher JI, Kamili A, Mayoh C, Bartenhagen C, Trahair TN, Xu N, Jayatilleke N, Wong M, Peng H, Atmadibrata B, Cheung BB, Lan Q, Bryan TM, Mestdagh P, Vandesompele J, Combaret V, Boeva V, Wang JY, Janoueix-Lerosey I, Cowley MJ, MacKenzie KL, Dolnikov A, Li J, Polly P, Marshall GM, Reddel RR, Norris MD, Haber M, Fischer M, Zhang XD, Pickett HA, and Liu T (2021). Targeted Therapy of TERT-Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy. Clin Cancer Res27, 1438-1451. doi:10.1158/1078-0432.CCR-20-3044.
  • Churin Y, Irungbam K, Imiela CS, Schwarz D, Mollenkopf HJ, Drebber U, Odenthal M, Pak O, Huber M, Glebe D, Roderfeld M, and Roeb E (2021). Lipid Storage and Interferon Response Determine the Phenotype of Ground Glass Hepatocytes in Mice and Humans. Cell Mol Gastroenterol Hepatol12, 383-394. doi:10.1016/j.jcmgh.2021.03.009.
  • Clemen CS, Schmidt A, Winter L, Canneva F, Wittig I, Becker L, Coras R, Berwanger C, German Mouse Clinic C, Hofmann A, Eggers B, Marcus K, Gailus-Durner V, Fuchs H, de Angelis MH, Kruger M, von Horsten S, Eichinger L, and Schroder R (2022). N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue. Neuropathol Appl Neurobiol48, e12750. doi:10.1111/nan.12750.
  • Crispatzu G, Rehimi R, Pachano T, Bleckwehl T, Cruz-Molina S, Xiao C, Mahabir E, Bazzi H, and Rada-Iglesias A (2021). The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo. Nat Commun12, 4344. doi:10.1038/s41467-021-24641-4.
  • Czauderna C, Poplawski A, O'Rourke CJ, Castven D, Perez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder DA, Schindeldecker M, Straub BK, Galle PR, Andersen JB, Thorgeirsson SS, Park YN, and Marquardt JU (2021). Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis. JCI Insight6. doi:10.1172/jci.insight.146196.
  • Dafinger C, Benzing T, Dotsch J, Schermer B, and Liebau MC (2021). Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality. Mol Cell Pediatr8, 1. doi:10.1186/s40348-021-00111-1.
  • Daimaguler HS, Akpulat U, Ozdemir O, Yis U, Gungor S, Talim B, Diniz G, Baydan F, Thiele H, Altmuller J, Nurnberg P, and Cirak S (2021). Clinical and genetic characterization of PYROXD1-related myopathy patients from Turkey. Am J Med Genet A185, 1678-1690. doi:10.1002/ajmg.a.62148.
  • Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons BD, and Bazzi H (2021). High proliferation and delamination during skin epidermal stratification. Nat Commun12, 3227. doi:10.1038/s41467-021-23386-4.
  • Derisbourg MJ, Wester LE, Baddi R, and Denzel MS (2021). Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation. Nat Commun12, 1678. doi:10.1038/s41467-021-21743-x.
  • Dieterich CL, Probst SI, Ueoka R, Sandu I, Schafle D, Molin MD, Minas HA, Costa R, Oxenius A, Sander P, and Piel J (2021). Aquimarins, Peptide Antibiotics with Amino-Modified C-Termini from a Sponge-Derived Aquimarina sp. Bacterium. Angew Chem Int Ed Engl, e202115802. doi:10.1002/anie.202115802.
  • Dodd GT, Kim SJ, Mequinion M, Xirouchaki CE, Bruning JC, Andrews ZB, and Tiganis T (2021). Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance. Sci Adv7. doi:10.1126/sciadv.abf4100.
  • Duhan V, Khairnar V, Kitanovski S, Hamdan TA, Klein AD, Lang J, Ali M, Adomati T, Bhat H, Friedrich SK, Li F, Krebs P, Futerman AH, Addo MM, Hardt C, Hoffmann D, Lang PA, and Lang KS (2020). Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells. Front Immunol11, 607889. doi:10.3389/fimmu.2020.607889.
  • Eberhardt KA, Dewald F, Heger E, Gieselmann L, Vanshylla K, Wirtz M, Kleipass F, Johannis W, Schommers P, Gruell H, Brensing KA, Muller RU, Augustin M, Lehmann C, Koch M, Klein F, and Di Cristanziano V (2021). Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG. Microorganisms9. doi:10.3390/microorganisms9040733.
  • Edlund K, Madjar K, Lebrecht A, Aktas B, Pilch H, Hoffmann G, Hofmann M, Kolberg HC, Boehm D, Battista M, Seehase M, Stewen K, Gebhard S, Cadenas C, Marchan R, Brenner W, Hasenburg A, Koelbl H, Solbach C, Gehrmann M, Tanner B, Weber KE, Loibl S, Sachinidis A, Rahnenfuhrer J, Schmidt M, and Hengstler JG (2021). Gene Expression-Based Prediction of Neoadjuvant Chemotherapy Response in Early Breast Cancer: Results of the Prospective Multicenter EXPRESSION Trial. Clin Cancer Res27, 2148-2158. doi:10.1158/1078-0432.CCR-20-2662.
  • Eisfeld HS, Simonis A, Winter S, Chhen J, Stroh LJ, Krey T, Koch M, Theobald SJ, and Rybniker J (2021). Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages. Viruses13. doi:10.3390/v13102076.
  • Erkelenz S, Stankovic D, Mundorf J, Bresser T, Claudius AK, Boehm V, Gehring NH, and Uhlirova M (2021). Ecd promotes U5 snRNP maturation and Prp8 stability. Nucleic Acids Res49, 1688-1707. doi:10.1093/nar/gkaa1274.
  • Escala-Garcia M, Canisius S, Keeman R, Beesley J, Anton-Culver H, Arndt V, Augustinsson A, Becher H, Beckmann MW, Behrens S, Bermisheva M, Bojesen SE, Bolla MK, Brenner H, Canzian F, Castelao JE, Chang-Claude J, Chanock SJ, Couch FJ, Czene K, Daly MB, Dennis J, Devilee P, Dork T, Dunning AM, Easton DF, Ekici AB, Eliassen AH, Fasching PA, Flyger H, Gago-Dominguez M, Garcia-Closas M, Garcia-Saenz JA, Geisler J, Giles GG, Grip M, Gundert M, Hahnen E, Haiman CA, Hakansson N, Hall P, Hamann U, Hartikainen JM, Heemskerk-Gerritsen BAM, Hollestelle A, Hoppe R, Hopper JL, Hunter DJ, Jacot W, Jakubowska A, John EM, Jung AY, Kaaks R, Khusnutdinova E, Koppert LB, Kraft P, Kristensen VN, Kurian AW, Lambrechts D, Le Marchand L, Lindblom A, Luben RN, Lubinski J, Mannermaa A, Manoochehri M, Margolin S, Mavroudis D, Muranen TA, Nevanlinna H, Olshan AF, Olsson H, Park-Simon TW, Patel AV, Peterlongo P, Pharoah PDP, Punie K, Radice P, Rennert G, Rennert HS, Romero A, Roylance R, Rudiger T, Ruebner M, Saloustros E, Sawyer EJ, Schmutzler RK, Schoemaker MJ, Scott C, Southey MC, Surowy H, Swerdlow AJ, Tamimi RM, Teras LR, Thomas E, Tomlinson I, Troester MA, Vachon CM, Wang Q, Winqvist R, Wolk A, Ziogas A, kConFab AI, Michailidou K, Chenevix-Trench G, Bachelot T, and Schmidt MK (2021). Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis. Sci Rep11, 19787. doi:10.1038/s41598-021-99409-3.
  • Fabretti F, Tschernoster N, Erger F, Hedergott A, Buescher AK, Dafinger C, Reusch B, Kontges VK, Kohl S, Bartram MP, Weber LT, Thiele H, Altmueller J, Schermer B, Beck BB, and Habbig S (2021). Expanding the Spectrum of FAT1 Nephropathies by Novel Mutations That Affect Hippo Signaling. Kidney Int Rep6, 1368-1378. doi:10.1016/j.ekir.2021.01.023.
  • Fedou C, Camus M, Lescat O, Feuillet G, Mueller I, Ross B, Buleon M, Neau E, Alves M, Goudouneche D, Breuil B, Boizard F, Bardou Q, Casemayou A, Tack I, Dreux S, Batut J, Blader P, Burlet-Schiltz O, Decramer S, Wirth B, Klein J, Saulnier-Blache JS, Buffin-Meyer B, and Schanstra JP (2021). Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies plastin 3 as a protein involved in glomerular integrity. J Pathol254, 575-588. doi:10.1002/path.5703.
  • Finger F, Ottens F, and Hoppe T (2021). The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis. MicroPubl Biol2021. doi:10.17912/micropub.biology.000457.
  • Fischer M, Moreno L, Ziegler DS, Marshall LV, Zwaan CM, Irwin MS, Casanova M, Sabado C, Wulff B, Stegert M, Wang L, Hurtado FK, Branle F, Geoerger B, Schulte JH (2021). Ceritinib in paediatric patients with anaplastic lymphoma kinase (ALK)-positive malignancies: a phase 1, open-label, dose-escalation study. Lancet Oncol 22(12), 1764-1776. doi: 10.1016/S1470-2045(21)00536-2.
  • Flores-Romero H, Hohorst L, John M, Albert MC, King LE, Beckmann L, Szabo T, Hertlein V, Luo X, Villunger A, Frenzel LP, Kashkar H, and Garcia-Saez AJ (2021). BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. EMBO J, e108690. doi:10.15252/embj.2021108690.
  • Flumann R, Rehkamper T, Nieper P, Pfeiffer P, Holzem A, Klein S, Bhatia S, Kochanek M, Kisis I, Pelzer BW, Ahlert H, Hauer J, da Palma Guerreiro A, Ryan JA, Reimann M, Riabinska A, Wiederstein J, Kruger M, Deckert M, Altmuller J, Klatt AR, Frenzel LP, Pasqualucci L, Beguelin W, Melnick AM, Sander S, Montesinos-Rongen M, Brunn A, Lohneis P, Buttner R, Kashkar H, Borkhardt A, Letai A, Persigehl T, Peifer M, Schmitt CA, Reinhardt HC, and Knittel G (2021). An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. Blood Cancer Discov2, 70-91. doi:10.1158/2643-3230.BCD-19-0059.
  • Franz A, Valledor P, Ubieto-Capella P, Pilger D, Galarreta A, Lafarga V, Fernandez-Llorente A, de la Vega-Barranco G, den Brave F, Hoppe T, Fernandez-Capetillo O, and Lecona E (2021). USP7 and VCP(FAF1) define the SUMO/Ubiquitin landscape at the DNA replication fork. Cell Rep37, 109819. doi:10.1016/j.celrep.2021.109819.
  • Franzen J, Georgomanolis T, Selich A, Kuo CC, Stoger R, Brant L, Mulabdic MS, Fernandez-Rebollo E, Grezella C, Ostrowska A, Begemann M, Nikolic M, Rath B, Ho AD, Rothe M, Schambach A, Papantonis A, and Wagner W (2021). DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift. Commun Biol4, 598. doi:10.1038/s42003-021-02116-y.
  • Friedrich SK, Schmitz R, Bergerhausen M, Lang J, Duhan V, Hardt C, Tenbusch M, Prinz M, Asano K, Bhat H, Hamdan TA, Lang PA, and Lang KS (2021). Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation. Pathogens10. doi:10.3390/pathogens10050622.
  • Furlan AG, Spanou CES, Godwin ARF, Wohl AP, Zimmermann LA, Imhof T, Koch M, Baldock C, and Sengle G (2021). A new MMP-mediated prodomain cleavage mechanism to activate bone morphogenetic proteins from the extracellular matrix. FASEB J35, e21353. doi:10.1096/fj.202001264R.
  • Gabriel E, Albanna W, Pasquini G, Ramani A, Josipovic N, Mariappan A, Schinzel F, Karch CM, Bao G, Gottardo M, Suren AA, Hescheler J, Nagel-Wolfrum K, Persico V, Rizzoli SO, Altmuller J, Riparbelli MG, Callaini G, Goureau O, Papantonis A, Busskamp V, Schneider T, and Gopalakrishnan J (2021). Human brain organoids assemble functionally integrated bilateral optic vesicles. Cell Stem Cell28, 1740-1757 e1748. doi:10.1016/j.stem.2021.07.010.
  • Garcia-Marquez MA, Thelen M, Reinke S, Keller D, Wennhold K, Lehmann J, Veldman J, Borchmann S, Rosenwald A, Sasse S, Diepstra A, Borchmann P, Engert A, Klapper W, von Bergwelt-Baildon M, Brockelmann PJ, and Schlosser HA (2021). Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma. Leukemia. doi:10.1038/s41375-021-01421-z.
  • Garcia LR, Tenev T, Newman R, Haich RO, Liccardi G, John SW, Annibaldi A, Yu L, Pardo M, Young SN, Fitzgibbon C, Fernando W, Guppy N, Kim H, Liang LY, Lucet IS, Kueh A, Roxanis I, Gazinska P, Sims M, Smyth T, Ward G, Bertin J, Beal AM, Geddes B, Choudhary JS, Murphy JM, Aurelia Ball K, Upton JW, and Meier P (2021). Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance. Nat Commun12, 3364. doi:10.1038/s41467-021-23474-5.
  • Geueke A, Mantellato G, Kuester F, Schettina P, Nelles M, Seeger JM, Kashkar H, and Niemann C (2021). The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function. EMBO Rep22, e52301. doi:10.15252/embr.202052301.
  • Gimpel C, Liebau MC, Schaefer F. „Systematic review on outcomes used in clinical research on autosomal recessive polycystic kidney disease—are patient-centered outcomes our blind spot?“ Pediatric Nephrology, 2021 Dec;36(12):3841-3851. doi: 10.1007/s00467-021-05192-8. 
  • Gizak A, Diegmann S, Dreha-Kulaczewski S, Wisniewski J, Duda P, Ohlenbusch A, Huppke B, Henneke M, Hohne W, Altmuller J, Thiele H, Nurnberg P, Rakus D, Gartner J, and Huppke P (2021). A novel remitting leukodystrophy associated with a variant in FBP2. Brain Commun3, fcab036. doi:10.1093/braincomms/fcab036.
  • Gluschko A, Farid A, Herb M, Grumme D, Kronke M, and Schramm M (2021). Macrophages target Listeria monocytogenes by two discrete non-canonical autophagy pathways. Autophagy, 1-18. doi:10.1080/15548627.2021.1969765.
  • Goranci-Buzhala G, Mariappan A, Ricci-Vitiani L, Josipovic N, Pacioni S, Gottardo M, Ptok J, Schaal H, Callaini G, Rajalingam K, Dynlacht B, Hadian K, Papantonis A, Pallini R, and Gopalakrishnan J (2021). Cilium induction triggers differentiation of glioma stem cells. Cell Rep36, 109656. doi:10.1016/j.celrep.2021.109656.
  • Grzes KM, Sanin DE, Kabat AM, Stanczak MA, Edwards-Hicks J, Matsushita M, Hackl A, Hassler F, Knoke K, Zahalka S, Villa M, Kofler DM, Voll RE, Zigrino P, Fabri M, Pearce EL, and Pearce EJ (2021). Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters. Immunity54, 2514-2530 e2517. doi:10.1016/j.immuni.2021.10.009.
  • Guerrero GA, Derisbourg MJ, Mayr FA, Wester LE, Giorda M, Dinort JE, Hartman MD, Schilling K, Alonso-De Gennaro MJ, Lu RJ, Benayoun BA, and Denzel MS (2021). NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants. Elife10. doi:10.7554/eLife.53174.
  • Hallenborg P, Jensen BAH, Fjaere E, Petersen RK, Belmaati MS, Rasmussen SS, Gunnarsson JP, Lauritzen P, Cheng KKY, Hermansson M, Sonne SB, Ejsing CS, Xu A, Kratchmarova I, Kruger M, Madsen L, Kristiansen K, and Blagoev B (2021). Adipose MDM2 regulates systemic insulin sensitivity. Sci Rep11, 21839. doi:10.1038/s41598-021-01240-3.
  • Halwe S, Kupke A, Vanshylla K, Liberta F, Gruell H, Zehner M, Rohde C, Krahling V, Gellhorn Serra M, Kreer C, Kluver M, Sauerhering L, Schmidt J, Cai Z, Han F, Young D, Yang G, Widera M, Koch M, Werner A, Kamper L, Becker N, Marlow MS, Eickmann M, Ciesek S, Schiele F, Klein F, and Becker S (2021). Intranasal Administration of a Monoclonal Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. Viruses13. doi:10.3390/v13081498.
  • Hamad S, Derichsweiler D, Hescheler J, Pfannkuche K. Scalable Generation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Methods Mol Biol. 2021 Oct 19. doi: 10.1007/7651_2021_395. Online ahead of print. PMID: 34664217
  • Handel A, Siebelmann S, Hos D, Ogrunc F, Matthaei M, Cursiefen C, and Bachmann B (2021). Comparison of Mini-DMEK versus predescemetal sutures as treatment of acute hydrops in keratoconus. Acta Ophthalmol99, e1326-e1333. doi:10.1111/aos.14835.
  • Hartlieb SA, Sieverling L, Nadler-Holly M, Ziehm M, Toprak UH, Herrmann C, Ishaque N, Okonechnikov K, Gartlgruber M, Park YG, Wecht EM, Savelyeva L, Henrich KO, Rosswog C, Fischer M, Hero B, Jones DTW, Pfaff E, Witt O, Pfister SM, Volckmann R, Koster J, Kiesel K, Rippe K, Taschner-Mandl S, Ambros P, Brors B, Selbach M, Feuerbach L, and Westermann F (2021). Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome. Nat Commun12, 1269. doi:10.1038/s41467-021-21247-8.
  • Hatje FA, Wedekind U, Sachs W, Loreth D, Reichelt J, Demir F, Kosub C, Heintz L, Tomas NM, Huber TB, Skuza S, Sachs M, Zielinski S, Rinschen MM, and Meyer-Schwesinger C (2021). Tripartite Separation of Glomerular Cell Types and Proteomes from Reporter-Free Mice. J Am Soc Nephrol32, 2175-2193. doi:10.1681/ASN.2020091346.
  • Hatzold J, Wessendorf H, Pogoda HM, Bloch W, and Hammerschmidt M (2021). The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development. Dev Biol476, 148-170. doi:10.1016/j.ydbio.2021.03.017.
  • Haumann S, Müller RU, Liebau MC. „Metabolic changes in polycystic kidney disease as a potential target for systemic treatment“; International Journal of Molecular Sciences. 2020, 21(17), 6093;
  • doi.org/10.3390/ijms21176093
  • Hayashi T, Zhang W, Hos D, Schrittenlocher S, Nhat Hung Le V, Siebelmann S, Matthaei M, Bock F, Bachmann B, and Cursiefen C (2021). Descemet Membrane Endothelial Keratoplasty in Vascularized Eyes: Outcome and Effect on Corneal Neovascularization. Cornea40, 685-689. doi:10.1097/ICO.0000000000002502.
  • He B, Chen P, Zambrano S, Dabaghie D, Hu Y, Moller-Hackbarth K, Unnersjo-Jess D, Korkut GG, Charrin E, Jeansson M, Bintanel-Morcillo M, Witasp A, Wennberg L, Wernerson A, Schermer B,Benzing T, Ernfors P, Betsholtz C, Lal M, Sandberg R, and Patrakka J (2021). Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes. Nat Commun12, 2141. doi:10.1038/s41467-021-22331-9.
  • Heath O, Berlato C, Maniati E, Lakhani A, Pegrum C, Kotantaki P, Elorbany S, Bohm S, Barry ST, Annibaldi A, Barton DP, and Balkwill FR (2021). Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer. Cancer Immunol Res9, 665-681. doi:10.1158/2326-6066.CIR-20-0968.
  • Hess S, Pouzat C, Paeger L, Pippow A, and Kloppenburg P (2021). Analysis of neuronal Ca(2+) handling properties by combining perforated patch clamp recordings and the added buffer approach. Cell Calcium97, 102411. doi:10.1016/j.ceca.2021.102411.
  • Heyckendorf J, Marwitz S, Reimann M, Avsar K, DiNardo AR, Gunther G, Hoelscher M, Ibraim E, Kalsdorf B, Kaufmann SHE, Kontsevaya I, van Leth F, Mandalakas AM, Maurer FP, Muller M, Nitschkowski D, Olaru ID, Popa C, Rachow A, Rolling T, Rybniker J, Salzer HJF, Sanchez-Carballo P, Schuhmann M, Schaub D, Spinu V, Suarez I, Terhalle E, Unnewehr M, Weiner J, 3rd, Goldmann T, and Lange C (2021). Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model. Eur Respir J58. doi:10.1183/13993003.03492-2020.
  • Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, Koningsbruggen-Rietschel SV, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri S, Savai R, Seeger W, Khatri P, Al Alam D, Dotsch J, and Alejandre Alcazar MA (2021). Macrophage-derived IL-6 trans-signaling as a novel target in the pathogenesis of bronchopulmonary dysplasia. Eur Respir J. doi:10.1183/13993003.02248-2020.
  • Hombach A, Barden M, Hannappel L, Chmielewski M, Rappl G,Sachinidis A, and Abken H (2021). IL12 integrated into the CAR exodomain convertsCD8(+) T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors. Mol Ther. doi:10.1016/j.ymthe.2021.10.011.
  • Horn C, Augustin M, Ercanoglu MS, Heger E, Knops E, Bondet V, Duffy D, Chon SH, Nierhoff D, Oette M, Schafer H, Vivaldi C, Held K, Anderson J, Geldmacher C, Suarez I, Rybniker J, Klein F, Fatkenheuer G, Muller-Trutwin M, and Lehmann C (2021). HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART. HIV Med22, 397-408. doi:10.1111/hiv.13031.
  • Hoyer-Allo KJR, Spath MR, Hanssen R, Johnsen M, Brodesser S, Kaufmann K, Kiefer K, Koehler FC, Gobel H, Kubacki T, Grundmann F, Schermer B,Bruning J, Benzing T, Burst V, and Muller RU (2021). Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. Int J Mol Sci22. doi:10.3390/ijms22115485.
  • Hribek A, Mestanoglu M, Clahsen T, Reinking N, Frentzen F, Howaldt A, Siebelmann S, Bachmann BO, Cursiefen C, and Matthaei M (2021). Scheimpflug Backscatter Imaging of the Fibrillar Layer in Fuchs Endothelial Corneal Dystrophy. Am J Ophthalmol235, 63-70. doi:10.1016/j.ajo.2021.08.019.
  • Hudecova I, Smith CG, Hansel-Hertsch R, Chilamakuri C, Morris JA, Vijayaraghavan A, Heider K, Chandrananda D, Cooper WN, Gale D, Garcia-Corbacho J, Pacey SC, Baird R, Rosenfeld N, and Mouliere F (2021). Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA. Genome Res. doi:10.1101/gr.275691.121.
  • Imach S, Wafaisade A, Lefering R, Bohmer A, Schieren M, Suarez V, Frohlich M, and TraumaRegister DGU (2021). The impact of prehospital tranexamic acid on mortality and transfusion requirements: match-pair analysis from the nationwide German TraumaRegister DGU(R). Crit Care25, 277. doi:10.1186/s13054-021-03701-7.
  • Imhof T, Balic A, Heilig J, Chiquet-Ehrismann R, Chiquet M, Niehoff A, Brachvogel B, Thesleff I, and Koch M (2020). Pivotal Role of Tenascin-W (-N) in Postnatal Incisor Growth and Periodontal Ligament Remodeling. Front Immunol11, 608223. doi:10.3389/fimmu.2020.608223.
  • Iqbal M, Maroofian R, Cavdarli B, Riccardi F, Field M, Banka S, Bubshait DK, Li Y, Hertecant J, Baig SM, Dyment D, Efthymiou S, Abdullah U, Makhdoom EUH, Ali Z, Scherf de Almeida T, Molinari F, Mignon-Ravix C, Chabrol B, Antony J, Ades L, Pagnamenta AT, Jackson A, Douzgou S, Genomics England Research C, Beetz C, Karageorgou V, Vona B, Rad A, Baig JM, Sultan T, Alvi JR, Maqbool S, Rahman F, Toosi MB, Ashrafzadeh F, Imannezhad S, Karimiani EG, Sarwar Y, Khan S, Jameel M, Noegel AA, Budde B, Altmuller J, Motameny S, Hohne W, Houlden H, Nurnberg P, Wollnik B, Villard L, Alkuraya FS, Osmond M, Hussain MS, and Yigit G (2021). Biallelic variants in PCDHGC4 cause a novel neurodevelopmental syndrome with progressive microcephaly, seizures, and joint anomalies. Genet Med23, 2138-2149. doi:10.1038/s41436-021-01260-4.
  • Izu Y, Adams SM, Connizzo BK, Beason DP, Soslowsky LJ, Koch M, and Birk DE (2021). Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function. Matrix Biol95, 52-67. doi:10.1016/j.matbio.2020.10.004.
  • Jakob L, Muller TA, Rassner M, Kleinfelder H, Veratti P, Mitschke J, Miething C, Oostendorp RAJ, Pfeifer D, Waterhouse M, and Duyster J (2021). Murine Oncostatin M Has Opposing Effects on the Proliferation of OP9 Bone Marrow Stromal Cells and NIH/3T3 Fibroblasts Signaling through the OSMR. Int J Mol Sci22. doi:10.3390/ijms222111649.
  • Jakobsen JR, Schjerling P, Svensson RB, Buhl R, Carstensen H, Koch M, Krogsgaard MR, Kjaer M, and Mackey AL (2021). RNA sequencing and immunofluorescence of the myotendinous junction of mature horses and humans. Am J Physiol Cell Physiol321, C453-C470. doi:10.1152/ajpcell.00218.2021.
  • Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernandez-Baldovinos J, Zhou L, Hoss C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Grone HJ, Graumann PL, Niessen CM, Offermanns S, Wickstrom SA, and Worzfeld T (2021). Mechanochemical control of epidermal stem cell divisions by B-plexins. Nat Commun12, 1308. doi:10.1038/s41467-021-21513-9.
  • Joachim A, Dewald F, Suarez I, Zemlin M, Lang I, Stutz R, Marthaler A, Bosse HM, Lubke N, Munch J, Bernard MA, Jeltsch K, Tonshoff B, Weidner N, Krausslich HG, Birzele L, Hubner J, Schmied P, Meyer-Buhn M, Horemheb-Rubio G, Cornely OA, Haverkamp H, Wiesmuller G, Fatkenheuer G, Hero B, Kaiser R, Dotsch J, Rybniker J, and group BFs (2021). Pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools - a cluster randomised trial. EClinicalMedicine39, 101082. doi:10.1016/j.eclinm.2021.101082.
  • Jobanputra V, Wrzeszczynski KO, Buttner R, Caldas C, Cuppen E, Grimmond S, Haferlach T, Mullighan C, Schuh A, and Elemento O (2021). Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology. Semin Cancer Biol. doi:10.1016/j.semcancer.2021.07.003.
  • Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, and Hatzoglou M (2021). Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress. Mol Cell81, 4191-4208 e4198. doi:10.1016/j.molcel.2021.09.029.
  • Johnson N, Maguire S, Morra A, Kapoor PM, Tomczyk K, Jones ME, Schoemaker MJ, Gilham C, Bolla MK, Wang Q, Dennis J, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Baynes C, Freeman LEB, Beckmann MW, Benitez J, Bermisheva M, Blomqvist C, Boeckx B, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Burwinkel B, Campa D, Canzian F, Castelao JE, Chanock SJ, Chenevix-Trench G, Clarke CL, Collaborators N, Conroy DM, Couch FJ, Cox A, Cross SS, Czene K, Dork T, Eliassen AH, Engel C, Evans DG, Fasching PA, Figueroa J, Floris G, Flyger H, Gago-Dominguez M, Gapstur SM, Garcia-Closas M, Gaudet MM, Giles GG, Goldberg MS, Gonzalez-Neira A, Group A, Guenel P, Hahnen E, Haiman CA, Hakansson N, Hall P, Hamann U, Harrington PA, Hart SN, Hooning MJ, Hopper JL, Howell A, Hunter DJ, Investigators A, kConFab I, Jager A, Jakubowska A, John EM, Kaaks R, Keeman R, Khusnutdinova E, Kitahara CM, Kosma VM, Koutros S, Kraft P, Kristensen VN, Kurian AW, Lambrechts D, Le Marchand L, Linet M, Lubinski J, Mannermaa A, Manoukian S, Margolin S, Martens JWM, Mavroudis D, Mayes R, Meindl A, Milne RL, Neuhausen SL, Nevanlinna H, Newman WG, Nielsen SF, Nordestgaard BG, Obi N, Olshan AF, Olson JE, Olsson H, Orban E, Park-Simon TW, Peterlongo P, Plaseska-Karanfilska D, Pylkas K, Rennert G, Rennert HS, Ruddy KJ, Saloustros E, Sandler DP, Sawyer EJ, Schmutzler RK, Scott C, Shu XO, Simard J, Smichkoska S, Sohn C, Southey MC, Spinelli JJ, Stone J, Tamimi RM, Taylor JA, Tollenaar R, Tomlinson I, Troester MA, Truong T, Vachon CM, van Veen EM, Wang SS, Weinberg CR, Wendt C, Wildiers H, Winqvist R, Wolk A, Zheng W, Ziogas A, Dunning AM, Pharoah PDP, Easton DF, Howie AF, Peto J, Dos-Santos-Silva I, Swerdlow AJ, Chang-Claude J, Schmidt MK, Orr N, and Fletcher O (2021). CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. Br J Cancer124, 842-854. doi:10.1038/s41416-020-01185-w.
  • Kaczmarek AT, Bahlmann N, Thaqi B, May P, and Schwarz G (2021). Machine learning-based identification and characterization of 15 novel pathogenic SUOX missense mutations. Mol Genet Metab134, 188-194. doi:10.1016/j.ymgme.2021.07.011.
  • Kaczmarek AT, Bender D, Gehling T, Kohl JB, Daimaguler HS, Santamaria-Araujo JA, Liebau MC, Koy A, Cirak S, and Schwarz G (2021). A defect in molybdenum cofactor binding causes an attenuated form of sulfite oxidase deficiency. J Inherit Metab Dis. doi:10.1002/jimd.12454.
  • Kanne J, Hussong M, Isensee J, Munoz-Lopez A, Wolffgramm J, Hess F, Grimm C, Bessonov S, Meder L, Wang J, Reinhardt HC, Odenthal M, Hucho T, Buttner R, Summerer D, and Schweiger MR (2021). Pericentromeric Satellite III transcripts induce etoposide resistance. Cell Death Dis12, 530. doi:10.1038/s41419-021-03810-9.
  • Kargapolova Y, Rehimi R, Kayserili H, Bruhl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmuller J, Nurnberg P, Langst G, Kaiser FJ, Watrin E, Brunner H, Rada-Iglesias A, Kurian L, Wollnik B, Bouazoune K, and Papantonis A (2021). Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology. Nat Commun12, 3014. doi:10.1038/s41467-021-23327-1.
  • Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, and Nogales E (2021). JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science371. doi:10.1126/science.abc3393.
  • Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, and Trifunovic A (2021). Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci Adv7. doi:10.1126/sciadv.abf0971.
  • Kasper P, Breuer S, Hoffmann T, Vohlen C, Janoschek R, Schmitz L, Appel S, Fink G, Hunseler C, Quaas A, Demir M, Lang S, Steffen HM, Martin A, Schramm C, Burger M, Mahabir E, Goeser T, Dotsch J, Hucklenbruch-Rother E, and Bae-Gartz I (2021). Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1alpha Axis in the Offspring of Obese Mothers. Cells10. doi:10.3390/cells10051247.
  • Katsiadaki I, Ellis T, Andersen L, Antczak P, Blaker E, Burden N, Fisher T, Green C, Labram B, Pearson A, Petersen K, Pickford D, Ramsden C, Ronneseth A, Ryder K, Sacker D, Stevens C, Watanabe H, Yamamoto H, Sewell F, Hawkins P, Rufli H, Handy RD, Maynard SK, and Jacobs MN (2021). Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint. Ecotoxicol Environ Saf223, 112585. doi:10.1016/j.ecoenv.2021.112585.
  • Keller N, Paketci C, Altmueller J, Fuhrmann N, Wunderlich G, Schrank B, Unver O, Yilmaz S, Boostani R, Karimiani EG, Motameny S, Thiele H, Nurnberg P, Maroofian R, Yis U, Wirth B, and Karakaya M (2021). Genomic variants causing mitochondrial dysfunction are common in hereditary lower motor neuron disease. Hum Mutat42, 460-472. doi:10.1002/humu.24181.
  • Khan AS, Wolf A, and Langmann T (2021). The AhR ligand 2, 2'-aminophenyl indole (2AI) regulates microglia homeostasis and reduces pro-inflammatory signaling. Biochem Biophys Res Commun579, 15-21. doi:10.1016/j.bbrc.2021.09.054.
  • Kiljan M, Weil S, Vasquez-Torres A, Hettich M, Mayer M, Ibruli O, Reinscheid M, Hesselmann I, Cai J, Niu LN, Sahbaz Y, Baues C, Baus WW, Kamp F, Marnitz S, Herter-Sprie GS, and Herter JM (2021). CyberKnife radiation therapy as a platform for translational mouse studies. Int J Radiat Biol97, 1261-1269. doi:10.1080/09553002.2021.1934749.
  • Kirschberg M, Syed AS, Donmez HG, Heuser S, Wilbrand-Hennes A, Alonso A, Hufbauer M, and Akgul B (2021). Novel Insights Into Cellular Changes in HPV8-E7 Positive Keratinocytes: A Transcriptomic and Proteomic Analysis. Front Microbiol12, 672201. doi:10.3389/fmicb.2021.672201.
  • Klapproth S, Richter K, Turk C, Bock T, Bromberger T, Dominik J, Huck K, Pfaller K, Hess MW, Reichel CA, Kruger M, Nakchbandi IA, and Moser M (2021). Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones. J Cell Sci134. doi:10.1242/jcs.259040.
  • Klein I, Wiesen MHJ, Albert V, Bobylev I, Joshi AR, Muller C, and Lehmann HC (2021). Impact of drug formulations on kinetics and toxicity in a preclinical model of paclitaxel-induced neuropathy. J Peripher Nerv Syst26, 216-226. doi:10.1111/jns.12440.
  • Klein S, Quaas A, Quantius J, Loser H, Meinel J, Peifer M, Wagner S, Gattenlohner S, Wittekindt C, von Knebel Doeberitz M, Prigge ES, Langer C, Noh KW, Maltseva M, Reinhardt HC, Buttner R, Klussmann JP, and Wuerdemann N (2021). Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains. Clin Cancer Res27, 1131-1138. doi:10.1158/1078-0432.CCR-20-3596.
  • Klimka A, Mertins S, Nicolai AK, Rummler LM, Higgins PG, Gunther SD, Tosetti B, Krut O, and Kronke M (2021). Epitope-specific immunity against Staphylococcus aureus coproporphyrinogen III oxidase. NPJ Vaccines6, 11. doi:10.1038/s41541-020-00268-2.
  • Klimpel A, Stillger K, Wiederstein JL, Kruger M, and Neundorf I (2021). Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells. FEBS J288, 2911-2929. doi:10.1111/febs.15612.
  • Kochanek M, Garcia Borrega J, Beckmann L, Neuhann J, Gathof BS, Di Cristanziano V, Hagmann H, and Borrega G (2022). Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy. Clin Kidney J15, 162-164. doi:10.1093/ckj/sfab095.
  • Koehler FC, Blomberg L, Brehm TT, Buttner S, Cornely OA, Degen O, Di Cristanziano V, Dolff S, Eberwein L, Hoxha E, Hoyer-Allo KJR, Rudolf S, Spath MR, Wanken M, Muller RU, and Burst V (2021). Development and design of the Hantavirus registry - HantaReg - for epidemiological studies, outbreaks and clinical studies on hantavirus disease. Clin Kidney J14, 2365-2370. doi:10.1093/ckj/sfab053.
  • Koehler S, Odenthal J, Ludwig V, Jess DU, Hohne M, Jungst C, Grawe F, Helmstadter M, Janku JL, Bergmann C, Hoyer PF, Hagmann HHH, Walz G, Bloch W, Niessen C, Schermer B, Wodarz A, Denholm B, Benzing T, Iden S, and Brinkkoetter PT (2021). Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier. Kidney Int. doi:10.1016/j.kint.2021.11.030.
  • Koester J, Miroshnikova YA, Ghatak S, Chacon-Martinez CA, Morgner J, Li X, Atanassov I, Altmuller J, Birk DE, Koch M, Bloch W, Bartusel M, Niessen CM, Rada-Iglesias A, and Wickstrom SA (2021). Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Nat Cell Biol23, 771-781. doi:10.1038/s41556-021-00705-x.
  • Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hovelmeyer N, Schafer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Buttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Bruning JC, Hallek M, Kruger M, Peifer M, Pallasch CP, and Wunderlich FT (2021). Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood137, 646-660. doi:10.1182/blood.2020005734.
  • Kolbuc M, Bienias B, Habbig S, Kolek MF, Szczepanska M, Kilis-Pstrusinska K, Wasilewska A, Adamczyk P, Motyka R, Tkaczyk M, Sikora P, Beck BB, and Zaniew M (2021). Hyperuricemia Is an Early and Relatively Common Feature in Children with HNF1B Nephropathy but Its Utility as a Predictor of the Disease Is Limited. J Clin Med10. doi:10.3390/jcm10153265.
  • Kong SL, Liu X, Tan SJ, Tai JA, Phua LY, Poh HM, Yeo T, Chua YW, Haw YX, Ling WH, Ng RCH, Tan TJ, Loh KWJ, Tan DS, Ng QS, Ang MK, Toh CK, Lee YF, Lim CT, Lim TKH, Hillmer AM, Yap YS, and Lim WT (2021). Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer. Front Oncol11, 698551. doi:10.3389/fonc.2021.698551.
  • Korenkov M, Poopalasingam N, Madler M, Vanshylla K, Eggeling R, Wirtz M, Fish I, Dewald F, Gieselmann L, Lehmann C, Fatkenheuer G, Gruell H, Pfeifer N, Heger E, and Klein F (2021). Evaluation of a Rapid Antigen Test To Detect SARS-CoV-2 Infection and Identify Potentially Infectious Individuals. J Clin Microbiol59, e0089621. doi:10.1128/JCM.00896-21.
  • Koyuncu S, Loureiro R, Lee HJ, Wagle P, Krueger M, and Vilchez D (2021). Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Nature596, 285-290. doi:10.1038/s41586-021-03781-z.
  • Krusche M, Osei-Davies R, Becker I, Grundmann F, Burst V, Kotter I, and Kubacki T (2021). Renal Function in Patients With Systemic Sclerosis: Do We Estimate It Correctly? J Clin Rheumatol. doi:10.1097/RHU.0000000000001791.
  • Kumar S, Koenig J, Schneider A, Wermeling F, Boddul S, Theobald SJ, Vollmer M, Kloos D, Lachmann N, Klawonn F, Lienenklaus S, Talbot SR, Bleich A, Wenzel N, von Kaisenberg C, Keck J, and Stripecke R (2021). In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution. Biomedicines9. doi:10.3390/biomedicines9080961.
  • Kumari S, Van TM, Preukschat D, Schuenke H, Basic M, Bleich A, Klein U, and Pasparakis M (2021). NF-kappaB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation. Life Sci Alliance4. doi:10.26508/lsa.202000956.
  • Lackner A, Sehlke R, Garmhausen M, Giuseppe Stirparo G, Huth M, Titz-Teixeira F, van der Lelij P, Ramesmayer J, Thomas HF, Ralser M, Santini L, Galimberti E, Sarov M, Stewart AF, Smith A, Beyer A, and Leeb M (2021). Cooperative genetic networks drive embryonic stem cell transition from naive to formative pluripotency. EMBO J40(8), e105776. doi:10.15252/embj.2020105776.
  • Lagolio E, Demurtas J, Buzzetti R, Cortassa G, Bottone S, Spadafora L, Cocino C, Smith L, Benzing T, and Polidori MC (2021). A rapid and feasible tool for clinical decision making in community-dwelling patients with COVID-19 and those admitted to emergency departments: the Braden-LDH-HorowITZ Assessment-BLITZ. Intern Emerg Med. doi:10.1007/s11739-021-02805-w.
  • Lakeman IMM, van den Broek AJ, Vos JAM, Barnes DR, Adlard J, Andrulis IL, Arason A, Arnold N, Arun BK, Balmana J, Barrowdale D, Benitez J, Borg A, Caldes T, Caligo MA, Chung WK, Claes KBM, Collaborators GS, Collaborators E, Collee JM, Couch FJ, Daly MB, Dennis J, Dhawan M, Domchek SM, Eeles R, Engel C, Evans DG, Feliubadalo L, Foretova L, Friedman E, Frost D, Ganz PA, Garber J, Gayther SA, Gerdes AM, Godwin AK, Goldgar DE, Hahnen E, Hake CR, Hamann U, Hogervorst FBL, Hooning MJ, Hopper JL, Hulick PJ, Imyanitov EN, Investigators O, Investigators H, KconFab I, Isaacs C, Izatt L, Jakubowska A, James PA, Janavicius R, Jensen UB, Jiao Y, John EM, Joseph V, Karlan BY, Kets CM, Konstantopoulou I, Kwong A, Legrand C, Leslie G, Lesueur F, Loud JT, Lubinski J, Manoukian S, McGuffog L, Miller A, Gomes DM, Montagna M, Mouret-Fourme E, Nathanson KL, Neuhausen SL, Nevanlinna H, Yie JNY, Olah E, Olopade OI, Park SK, Parsons MT, Peterlongo P, Piedmonte M, Radice P, Rantala J, Rennert G, Risch HA, Schmutzler RK, Sharma P, Simard J, Singer CF, Stadler Z, Stoppa-Lyonnet D, Sutter C, Tan YY, Teixeira MR, Teo SH, Teule A, Thomassen M, Thull DL, Tischkowitz M, Toland AE, Tung N, van Rensburg EJ, Vega A, Wappenschmidt B, Devilee P, van Asperen CJ, Bernstein JL, Offit K, Easton DF, Rookus MA, Chenevix-Trench G, Antoniou AC, Robson M, and Schmidt MK (2021). The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant. Genet Med23, 1726-1737. doi:10.1038/s41436-021-01198-7.
  • Lawton E, Antczak P, Walker S, Germain-Cripps E, Falciani F, and Routledge EJ (2021). An investigation into the biological effects of indirect potable reuse water using zebrafish embryos. Sci Total Environ789, 147981. doi:10.1016/j.scitotenv.2021.147981.
  • Lenders M, Nordbeck P, Kurschat C, Eveslage M, Karabul N, Kaufeld J, Hennermann JB, Patten M, Cybulla M, Muntze J, Uceyler N, Liu D, Das AM, Sommer C, Pogoda C, Reiermann S, Duning T, Gaedeke J, von Cossel K, Blaschke D, Brand SM, Alexander Mann W, Kampmann C, Muschol N, Canaan-Kuhl S, and Brand E (2021). Treatment of fabry disease with migalastat-outcome from a prospective 24 months observational multicenter study (FAMOUS). Eur Heart J Cardiovasc Pharmacother. doi:10.1093/ehjcvp/pvab025.
  • Lessel D, Rading K, Campbell SE, Thiele H, Altmuller J, Gordon LB, and Kubisch C (2022). A novel homozygous synonymous variant further expands the phenotypic spectrum of POLR3A-related pathologies. Am J Med Genet A188, 216-223. doi:10.1002/ajmg.a.62525.
  • Leuchte K, Staib E, Thelen M, Godel P, Lechner A, Zentis P, Garcia-Marquez M, Waldschmidt D, Datta RR, Wahba R, Wybranski C, Zander T, Quaas A, Drebber U, Stippel DL, Bruns C, von Bergwelt-Baildon M, Wennhold K, and Schlosser HA (2021). Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma. Cancer Immunol Immunother70, 893-907. doi:10.1007/s00262-020-02734-1.
  • Li J, Wu X, Schiffmann L, MacVicar T, Zhou C, Wang Z, Li D, Camacho OV, Heuchel R, Odenthal M, Hillmer A, Quaas A, Zhao Y, Bruns CJ, and Popp FC (2021). IL-17B/RB Activation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Metabolism and Growth. Cancers (Basel)13. doi:10.3390/cancers13215338.
  • Li N, Zethoven M, McInerny S, Devereux L, Huang YK, Thio N, Cheasley D, Gutierrez-Enriquez S, Moles-Fernandez A, Diez O, Nguyen-Dumont T, Southey MC, Hopper JL, Simard J, Dumont M, Soucy P, Meindl A, Schmutzler R, Schmidt MK, Adank MA, Andrulis IL, Hahnen E, Engel C, Lesueur F, Girard E, Neuhausen SL, Ziv E, Allen J, Easton DF, Scott RJ, Gorringe KL, James PA, and Campbell IG (2021). Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects. NPJ Breast Cancer7, 52. doi:10.1038/s41523-021-00255-3.
  • Llamas E, Torres-Montilla S, Lee HJ, Barja MV, Schlimgen E, Dunken N, Wagle P, Werr W, Zuccaro A, Rodriguez-Concepcion M, and Vilchez D (2021). The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress. Aging Cell20, e13446. doi:10.1111/acel.13446.
  • Lobastova L, Lettau M, Babatz F, de Oliveira TD, Nguyen PH, Pauletti BA, Schauss AC, Durkop H, Janssen O, Paes Leme AF, Hallek M, and Hansen HP (2021). CD30-Positive Extracellular Vesicles Enable the Targeting of CD30-Negative DLBCL Cells by the CD30 Antibody-Drug Conjugate Brentuximab Vedotin. Front Cell Dev Biol9, 698503. doi:10.3389/fcell.2021.698503.
  • Luckstadt W, Bub S, Koudelka T, Pavlenko E, Peters F, Somasundaram P, Becker-Pauly C, Lucius R, Zunke F, and Arnold P (2021). Cell Surface Processing of CD109 by Meprin beta Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles. Front Cell Dev Biol9, 622390. doi:10.3389/fcell.2021.622390.
  • Macha A, Liebsch F, Fricke S, Hetsch F, Neuser F, Johannes L, Kress V, Djemie T, Santamaria-Araujo JA, Vilain C, Aeby A, Van Bogaert P, Dejanovic B, Weckhuysen S, Meier JC, and Schwarz G (2021). Bi-allelic gephyrin variants impair GABAergic inhibition in a patient with epileptic encephalopathy. Hum Mol Genet. doi:10.1093/hmg/ddab298.
  • Machado R, Sachinidis A, and Futschik ME (2021). Detection of Novel Potential Regulators of Stem Cell Differentiation and Cardiogenesis through Combined Genome-Wide Profiling of Protein-Coding Transcripts and microRNAs. Cells10. doi:10.3390/cells10092477.
  • Mahlich D, Glasmacher A, Muller I, Oppermann J, Grevenstein D, Eysel P, Heilig J, Wirth B, Zaucke F, and Niehoff A (2021). Expression and Localization of Thrombospondins, Plastin 3, and STIM1 in Different Cartilage Compartments of the Osteoarthritic Varus Knee. Int J Mol Sci22. doi:10.3390/ijms22063073.
  • Makhdoom EUH, Waseem SS, Iqbal M, Abdullah U, Hussain G, Asif M, Budde B, Hohne W, Tinschert S, Saadi SM, Yousaf H, Ali Z, Fatima A, Kaygusuz E, Khan A, Jameel M, Khan S, Tariq M, Anjum I, Altmuller J, Thiele H, Honing S, Baig SM, Nurnberg P, and Hussain MS (2021). Modifier Genes in Microcephaly: A Report on WDR62, CEP63, RAD50 and PCNT Variants Exacerbating Disease Caused by Biallelic Mutations of ASPM and CENPJ. Genes (Basel)12. doi:10.3390/genes12050731.
  • Mangold N, Pippin J, Unnersjoe-Jess D, Koehler S, Shankland S, Brahler S, Schermer B, Benzing T, Brinkkoetter PT, and Hagmann H (2021). The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development. Cells10. doi:10.3390/cells10092464.
  • Martinez-Morcillo FJ, Canton-Sandoval J, Martinez-Navarro FJ, Cabas I, Martinez-Vicente I, Armistead J, Hatzold J, Lopez-Munoz A, Martinez-Menchon T, Corbalan-Velez R, Lacal J, Hammerschmidt M, Garcia-Borron JC, Garcia-Ayala A, Cayuela ML, Perez-Oliva AB, Garcia-Moreno D, and Mulero V (2021). NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. PLoS Biol19, e3001455. doi:10.1371/journal.pbio.3001455.
  • Matsushita M, Awazawa M, Kobayashi N, Ikushima YM, Soeda K, Tamura-Nakano M, Muratani M, Kobayashi K, Bluher M, Bruning JC, and Ueki K (2021). An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance. Cell Chem Biol. doi:10.1016/j.chembiol.2021.12.008.
  • Meder L, Florin A, Ozretic L, Nill M, Koker M, Meemboor S, Radtke F, Diehl L, Ullrich RT, Odenthal M, Buttner R, and Heukamp LC (2021). Notch1 Deficiency Induces Tumor Cell Accumulation Inside the Bronchiolar Lumen and Increases TAZ Expression in an Autochthonous Kras (LSL-G12V) Driven Lung Cancer Mouse Model. Pathol Oncol Res27, 596522. doi:10.3389/pore.2021.596522.
  • Meijers M, Vanshylla K, Gruell H, Klein F, and Lassig M (2021). Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody. Proc Natl Acad Sci U S A118. doi:10.1073/pnas.2104651118.
  • Meinberger D, Koch M, Roth A, Hermes G, Stemler J, Cornely OA, Streichert T, and Klatt AR (2021). Analysis of IgM, IgA, and IgG isotype antibodies Directed against SARS-CoV-2 spike glycoprotein and ORF8 in the course of COVID-19. Sci Rep11, 8920. doi:10.1038/s41598-021-88356-8.
  • Mellis AT, Misko AL, Arjune S, Liang Y, Erdelyi K, Ditroi T, Kaczmarek AT, Nagy P, and Schwarz G (2021). The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H2S metabolism. Redox Biol38, 101800. doi:10.1016/j.redox.2020.101800.
  • Mellis AT, Roeper J, Misko AL, Kohl J, and Schwarz G (2020). Sulfite Alters the Mitochondrial Network in Molybdenum Cofactor Deficiency. Front Genet11, 594828. doi:10.3389/fgene.2020.594828.
  • Messner M, Mandl MM, Hackl MW, Reinhardt T, Ardelt MA, Szczepanowska K, Fradrich JE, Waschke J, Jeremias I, Fux A, Stahl M, Vollmar AM, Sieber SA, and Pachmayr J (2021). Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers. Sci Rep11, 11185. doi:10.1038/s41598-021-90801-7.
  • Metry EL, Garrelfs SF, Peters-Sengers H, Hulton SA, Acquaviva C, Bacchetta J, Beck BB, Collard L, Deschenes G, Franssen C, Kemper MJ, Lipkin GW, Mandrile G, Mohebbi N, Moochhala SH, Oosterveld MJS, Prikhodina L, Hoppe B, Cochat P, Groothoff JW, and OxalEurope C (2022). Long-Term Transplantation Outcomes in Patients With Primary Hyperoxaluria Type 1 Included in the European Hyperoxaluria Consortium (OxalEurope) Registry. Kidney Int Rep7, 210-220. doi:10.1016/j.ekir.2021.11.006.
  • Meyer A, Yan S, Golumba-Nagy V, Esser RL, Barbarino V, Blakemore SJ, Rusyn L, Nikiforov A, Seeger-Nukpezah T, Grull H, Pallasch CP, and Kofler DM (2021). Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis. J Autoimmun124, 102726. doi:10.1016/j.jaut.2021.102726.
  • Meyer DH, and Schumacher B (2021). BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy. Aging Cell20, e13320. doi:10.1111/acel.13320.
  • Mitra S, Muralidharan SV, Marco MD, Juvvuna PK, Kosalai ST, Reischl S, Jachimowicz D, Subhash S, Raimondi I, Kurian L, Huarte M, Kogner P, Fischer M, Johnsen JI, Mondal T, and Kanduri C (2021). Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma. Cancer Res81, 1457-1471. doi:10.1158/0008-5472.CAN-19-3499.
  • Mollenhauer M, Bokredenghel S, Geissen S, Klinke A, Morstadt T, Torun M, Strauch S, Schumacher W, Maass M, Konradi J, Peters VBM, Berghausen E, Vantler M, Rosenkranz S, Mehrkens D, Braumann S, Nettersheim F, Hof A, Simsekyilmaz S, Winkels H, Rudolph V, Baldus S, Adam M, and Freyhaus HT (2021). Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation. Front Immunol12, 701721. doi:10.3389/fimmu.2021.701721.
  • Montinaro A, Areso Zubiaur I, Saggau J, Kretz AL, Ferreira RMM, Hassan O, Kitzig E, Muller I, El-Bahrawy MA, von Karstedt S, Kulms D, Liccardi G, Lemke J, and Walczak H (2021). Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. Cell Death Differ. doi:10.1038/s41418-021-00869-x.
  • Morra A, Escala-Garcia M, Beesley J, Keeman R, Canisius S, Ahearn TU, Andrulis IL, Anton-Culver H, Arndt V, Auer PL, Augustinsson A, Beane Freeman LE, Becher H, Beckmann MW, Behrens S, Bojesen SE, Bolla MK, Brenner H, Bruning T, Buys SS, Caan B, Campa D, Canzian F, Castelao JE, Chang-Claude J, Chanock SJ, Cheng TD, Clarke CL, Collaborators N, Colonna SV, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Dennis J, Dork T, Dossus L, Dunning AM, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Eriksson M, Evans DG, Fasching PA, Flyger H, Fritschi L, Gago-Dominguez M, Garcia-Saenz JA, Giles GG, Grip M, Guenel P, Gundert M, Hahnen E, Haiman CA, Hakansson N, Hall P, Hamann U, Hart SN, Hartikainen JM, Hartmann A, He W, Hooning MJ, Hoppe R, Hopper JL, Howell A, Hunter DJ, Investigators A, kConFab I, Jager A, Jakubowska A, Janni W, John EM, Jung AY, Kaaks R, Keupers M, Kitahara CM, Koutros S, Kraft P, Kristensen VN, Kurian AW, Lacey JV, Lambrechts D, Le Marchand L, Lindblom A, Linet M, Luben RN, Lubinski J, Lush M, Mannermaa A, Manoochehri M, Margolin S, Martens JWM, Martinez ME, Mavroudis D, Michailidou K, Milne RL, Mulligan AM, Muranen TA, Nevanlinna H, Newman WG, Nielsen SF, Nordestgaard BG, Olshan AF, Olsson H, Orr N, Park-Simon TW, Patel AV, Peissel B, Peterlongo P, Plaseska-Karanfilska D, Prajzendanc K, Prentice R, Presneau N, Rack B, Rennert G, Rennert HS, Rhenius V, Romero A, Roylance R, Ruebner M, Saloustros E, Sawyer EJ, Schmutzler RK, Schneeweiss A, Scott C, Shah M, Smichkoska S, Southey MC, Stone J, Surowy H, Swerdlow AJ, Tamimi RM, Tapper WJ, Teras LR, Terry MB, Tollenaar R, Tomlinson I, Troester MA, Truong T, Vachon CM, Wang Q, Hurson AN, Winqvist R, Wolk A, Ziogas A, Brauch H, Garcia-Closas M, Pharoah PDP, Easton DF, Chenevix-Trench G, and Schmidt MK (2021). Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment. Breast Cancer Res23, 86. doi:10.1186/s13058-021-01450-7.
  • Moya-Torres A, Gupta M, Heide F, Krahn N, Legare S, Nikodemus D, Imhof T, Meier M, Koch M, and Stetefeld J (2021). Homogenous overexpression of the extracellular matrix protein Netrin-1 in a hollow fiber bioreactor. Appl Microbiol Biotechnol105, 6047-6057. doi:10.1007/s00253-021-11438-0.
  • Müller FM, Meyer AM, Pickert L, Heeß A, Becker I, Benzing T & Polidori MC (2021) An interdisciplinary intervention is associated with overall improvement of older inpatients in a non-geriatric setting: A retrospective analysis of an observational, longitudinal study with one-year follow up. Geriatric Care 7.
  • Muller L, Kutzner CE, Balaji V, and Hoppe T (2021). In Vitro Analysis of E3 Ubiquitin Ligase Function. J Vis Exp. doi:10.3791/62393.
  • Murakami T, Shoji Y, Nishi T, Chang SC, Jachimowicz RD, Hoshimoto S, Ono S, Shiloh Y, Takeuchi H, Kitagawa Y, Hoon DSB, and Bustos MA (2021). Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma. Mol Oncol15, 1069-1087. doi:10.1002/1878-0261.12929.
  • Murschall LM, Peker E, MacVicar T, Langer T, and Riemer J (2021). Protein Import Assay into Mitochondria Isolated from Human Cells. Bio Protoc11, e4057. doi:10.21769/BioProtoc.4057.
  • Myall AC, Perkins S, Rushton D, David J, Spencer P, Jones AR, and Antczak P (2021). An OMICs based meta-analysis to support infection state stratification. Bioinformatics. doi:10.1093/bioinformatics/btab089.
  • Nettersheim FS, Braumann S, Kobiyama K, Orecchioni M, Vassallo M, Miller J, Ali A, Roy P, Saigusa R, Wolf D, Ley K, and Winkels H (2021). Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B. Front Cardiovasc Med8, 812769. doi:10.3389/fcvm.2021.812769.

  • Nettersheim FS, Lemties J, Braumann S, Geissen S, Bokredenghel S, Nies R, Hof A, Winkels H, Freeman BA, Klinke A, Rudolph V, Baldus S, Mehrkens D, Mollenhauer M, and Adam M (2021). Nitro-oleic acid (NO2-OA) reduces thoracic aortic aneurysm progression in a mouse model of Marfan syndrome. Cardiovasc Res. doi:10.1093/cvr/cvab256.
  • Nguyen DMT, Iuzzolino ML, Mankel A, Bozek K, Stephens GJ, and Peleg O (2021). Flow-mediated olfactory communication in honeybee swarms. Proc Natl Acad Sci U S A118. doi:10.1073/pnas.2011916118.
  • Noetzel N, Meyer AM, Siri G, Pickert L, Heeß A, Verleysdonk J, Benzing T, Pilotto A, Barbe AG & Polidori MC (2021) The impact of oral health on prognosis of older multimorbid inpatients: the 6-month follow up MPI oral health study (MPIOH). Eur Geriatr Med 12, 263–273.
  • Norrick A, Esterlechner J, Niebergall-Roth E, Dehio U, Sadeghi S, Schroder HM, Ballikaya S, Stemler N, Ganss C, Dieter K, Dachtler AK, Merz P, Sel S, Chodosh J, Cursiefen C, Frank NY, Auffarth GU, Ksander B, Frank MH, and Kluth MA (2021). Process development and safety evaluation of ABCB5(+) limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency. Stem Cell Res Ther12, 194. doi:10.1186/s13287-021-02272-2.
  • Obenaus M, Schildgen O, Schurmann D, von Brunneck AC, Janz M, Keller U, Gebauer B, Schilling J, Schwartz S, Weissbrich B, Schneider T, Hofmann J, and Mathas S (2021). High-dose glucocorticoid treatment of near-fatal bocavirus lung infection results in rapid recovery. ERJ Open Res7. doi:10.1183/23120541.00060-2021.
  • Oikonomou N, Schuijs MJ, Chatzigiagkos A, Androulidaki A, Aidinis V, Hammad H, Lambrecht BN, and Pasparakis M (2021). Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation. Mucosal Immunol14, 1160-1171. doi:10.1038/s41385-021-00415-5.
  • Otte MS, Bork ML, Zimmermann PH, Klussmann JP, and Luers JC (2021). Patients with COVID-19-associated olfactory impairment also show impaired trigeminal function. Auris Nasus Larynx. doi:10.1016/j.anl.2021.07.012.
  • Otte MS, Bork ML, Zimmermann PH, Klussmann JP, and Luers JC (2021). Persisting olfactory dysfunction improves in patients 6 months after COVID-19 disease. Acta Otolaryngol141, 626-629. doi:10.1080/00016489.2021.1905178.
  • Ou HL, and Schumacher B (2021). Evaluating DNA damage response through immunofluorescence staining of primordial germ cells in Caenorhabditis elegans L1 larva. STAR Protoc2, 100441. doi:10.1016/j.xpro.2021.100441.
  • Pachano T, Sanchez-Gaya V, Ealo T, Mariner-Fauli M, Bleckwehl T, Asenjo HG, Respuela P, Cruz-Molina S, Munoz-San Martin M, Haro E, van IWFJ, Landeira D, and Rada-Iglesias A (2021). Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness. Nat Genet53, 1036-1049. doi:10.1038/s41588-021-00888-x.
  • Pacholewska A, Grimm C, Herling CD, Lienhard M, Konigs A, Timmermann B, Altmuller J, Mucke O, Reinhardt HC, Plass C, Herwig R, Hallek M, and Schweiger MR (2021). Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients. Int J Mol Sci22. doi:10.3390/ijms22179337.
  • Pagnamenta AT, Kaiyrzhanov R, Zou Y, Da'as SI, Maroofian R, Donkervoort S, Dominik N, Lauffer M, Ferla MP, Orioli A, Giess A, Tucci A, Beetz C, Sedghi M, Ansari B, Barresi R, Basiri K, Cortese A, Elgar G, Fernandez-Garcia MA, Yip J, Foley AR, Gutowski N, Jungbluth H, Lassche S, Lavin T, Marcelis C, Marks P, Marini-Bettolo C, Medne L, Moslemi AR, Sarkozy A, Reilly MM, Muntoni F, Millan F, Muraresku CC, Need AC, Nemeth AH, Neuhaus SB, Norwood F, O'Donnell M, O'Driscoll M, Rankin J, Yum SW, Zolkipli-Cunningham Z, Brusius I, Wunderlich G, Genomics England Research C, Karakaya M, Wirth B, Fakhro KA, Tajsharghi H, Bonnemann CG, Taylor JC, and Houlden H (2021). An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy. Brain144, 584-600. doi:10.1093/brain/awaa420.
  • Park HA, Neumeyer S, Michailidou K, Bolla MK, Wang Q, Dennis J, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Baten A, Beane Freeman LE, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Brucker SY, Burwinkel B, Campa D, Canzian F, Castelao JE, Chanock SJ, Chenevix-Trench G, Clarke CL, Collaborators N, Conroy DM, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dork T, Dos-Santos-Silva I, Dwek M, Eccles DM, Eliassen AH, Engel C, Eriksson M, Evans DG, Fasching PA, Flyger H, Fritschi L, Garcia-Closas M, Garcia-Saenz JA, Gaudet MM, Giles GG, Glendon G, Goldberg MS, Goldgar DE, Gonzalez-Neira A, Grip M, Guenel P, Hahnen E, Haiman CA, Hakansson N, Hall P, Hamann U, Han S, Harkness EF, Hart SN, He W, Heemskerk-Gerritsen BAM, Hopper JL, Hunter DJ, Investigators A, kConFab I, Jager A, Jakubowska A, John EM, Jung A, Kaaks R, Kapoor PM, Keeman R, Khusnutdinova E, Kitahara CM, Koppert LB, Koutros S, Kristensen VN, Kurian AW, Lacey J, Lambrechts D, Le Marchand L, Lo WY, Lubinski J, Mannermaa A, Manoochehri M, Margolin S, Martinez ME, Mavroudis D, Meindl A, Menon U, Milne RL, Muranen TA, Nevanlinna H, Newman WG, Nordestgaard BG, Offit K, Olshan AF, Olsson H, Park-Simon TW, Peterlongo P, Peto J, Plaseska-Karanfilska D, Presneau N, Radice P, Rennert G, Rennert HS, Romero A, Saloustros E, Sawyer EJ, Schmidt MK, Schmutzler RK, Schoemaker MJ, Schwentner L, Scott C, Shah M, Shu XO, Simard J, Smeets A, Southey MC, Spinelli JJ, Stevens V, Swerdlow AJ, Tamimi RM, Tapper WJ, Taylor JA, Terry MB, Tomlinson I, Troester MA, Truong T, Vachon CM, van Veen EM, Vijai J, Wang S, Wendt C, Winqvist R, Wolk A, Ziogas A, Dunning AM, Pharoah PDP, Easton DF, Zheng W, Kraft P, and Chang-Claude J (2021). Mendelian randomisation study of smoking exposure in relation to breast cancer risk. Br J Cancer125, 1135-1145. doi:10.1038/s41416-021-01432-8.
  • Pavinato L, Nematian-Ardestani E, Zonta A, De Rubeis S, Buxbaum J, Mancini C, Bruselles A, Tartaglia M, Pessia M, Tucker SJ, D'Adamo MC, and Brusco A (2021). KCNK18 Biallelic Variants Associated with Intellectual Disability and Neurodevelopmental Disorders Alter TRESK Channel Activity. Int J Mol Sci22. doi:10.3390/ijms22116064.
  • Pedrera L, Espiritu RA, Ros U, Weber J, Schmitt A, Stroh J, Hailfinger S, von Karstedt S, and Garcia-Saez AJ (2021). Ferroptotic pores induce Ca(2+) fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ28, 1644-1657. doi:10.1038/s41418-020-00691-x.
  • Peinkofer G, Maass M, Pfannkuche K, Sachinidis A, Baldus S, Hescheler J, Saric T, and Halbach M (2021). Persistence of intramyocardially transplanted murine induced pluripotent stem cell-derived cardiomyocytes from different developmental stages. Stem Cell Res Ther12, 46. doi:10.1186/s13287-020-02089-5.
  • Perne C, Peters S, Cartolano M, Horpaopan S, Grimm C, Altmuller J, Sommer AK, Hillmer AM, Thiele H, Odenthal M, Moslein G, Adam R, Sivalingam S, Kirfel J, Schweiger MR, Peifer M, Spier I, and Aretz S (2021). Variant profiling of colorectal adenomas from three patients of two families with MSH3-related adenomatous polyposis. PLoS One16, e0259185. doi:10.1371/journal.pone.0259185.
  • Peters F, Fiebig B, Lundberg P, Jaspers NI, Holzapfel B, Ghadimi MPH, Drebber U, Tuchscherer A, Ullrich R, Hartmann K, and Tantcheva-Poor I (2021). Detection of the germline KIT S476I mutation in a kindred with familial mastocytosis associated with gastrointestinal stromal tumors. J Allergy Clin Immunol Pract9, 2123-2125 e2121. doi:10.1016/j.jaip.2020.12.049.
  • Pickert L, Meyer AM, Becker I, Heeß A, Noetzel N, Brinkkötter P, Pilotto A, Benzing T & Polidori MC (2021) Role of a multidimensional prognosis in-hospital monitoring for older patients with prolonged stay. Int J Clin Pract 75, e13989.
  • Pottie L, Adamo CS, Beyens A, Lutke S, Tapaneeyaphan P, De Clercq A, Salmon PL, De Rycke R, Gezdirici A, Gulec EY, Khan N, Urquhart JE, Newman WG, Metcalfe K, Efthymiou S, Maroofian R, Anwar N, Maqbool S, Rahman F, Altweijri I, Alsaleh M, Abdullah SM, Al-Owain M, Hashem M, Houlden H, Alkuraya FS, Sips P, Sengle G, and Callewaert B (2021). Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome. Am J Hum Genet108, 1095-1114. doi:10.1016/j.ajhg.2021.04.016.
  • Power JJ, Pinheiro F, Pompei S, Kovacova V, Yuksel M, Rathmann I, Forster M, Lassig M, and Maier B (2021). Adaptive evolution of hybrid bacteria by horizontal gene transfer. Proc Natl Acad Sci U S A118. doi:10.1073/pnas.2007873118.
  • Raieli S, Di Renzo D, Lampis S, Amadesi C, Montemurro L, Pession A, Hrelia P, Fischer M, and Tonelli R (2021). MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma. Front Oncol11, 625207. doi:10.3389/fonc.2021.625207.
  • Ramzan S, Tennstedt S, Tariq M, Khan S, Noor Ul Ayan H, Ali A, Munz M, Thiele H, Korejo AA, Mughal AR, Jamal SZ, Nurnberg P, Baig SM, Erdmann J, and Ahmad I (2021). A Novel Missense Mutation in TNNI3K Causes Recessively Inherited Cardiac Conduction Disease in a Consanguineous Pakistani Family. Genes (Basel)12. doi:10.3390/genes12081282.
  • Rarek MP, Meyer AM, Pickert L, Pilotto A, Benzing T, Burst V & Polidori MC (2021) The prognostic signature of health-related quality of life in older patients admitted to the emergency department: a 6-month follow-up study. Aging Clin Exp Res 33, 2203–2211.
  • Reder H, Wagner S, Wuerdemann N, Langer C, Sandmann S, Braeuninger A, Dugas M, Gattenloehner S, Wittekindt C, and Klussmann JP (2021). Mutation patterns in recurrent and/or metastatic oropharyngeal squamous cell carcinomas in relation to human papillomavirus status. Cancer Med10, 1347-1356. doi:10.1002/cam4.3741.
  • Reusch B, Bartram MP, Dafinger C, Palacio-Escat N, Wenzel A, Fenton RA, Saez-Rodriguez J, Schermer B, Benzing T, Altmuller J, Beck BB, and Rinschen MM (2022). MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells. J Proteomics252, 104424. doi:10.1016/j.jprot.2021.104424.
  • Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L, Nielsen SR, McNeilly S, Prein C, Rafaeva M, Schoof EM, Furtwangler B, Porse BT, Kim H, Won KJ, Sudhop S, Zornhagen KW, Suhr F, Maniati E, Pearce OMT, Koch M, Oddershede LB, Van Agtmael T, Madsen CD, Mayorca-Guiliani AE, Bloch W, Netz RR, Clausen-Schaumann H, and Erler JT (2021). Basement membrane stiffness determines metastases formation. Nat Mater20, 892-903. doi:10.1038/s41563-020-00894-0.
  • Rosswog C, Bartenhagen C, Welte A, Kahlert Y, Hemstedt N, Lorenz W, Cartolano M, Ackermann S, Perner S, Vogel W, Altmuller J, Nurnberg P, Hertwig F, Gohring G, Lilienweiss E, Stutz AM, Korbel JO, Thomas RK, Peifer M, and Fischer M (2021). Chromothripsis followed by circular recombination drives oncogene amplification in human cancer. Nat Genet53, 1673-1685. doi:10.1038/s41588-021-00951-7.
  • Rudek LS, Zimmermann K, Galla M, Meyer J, Kuehle J, Stamopoulou A, Brand D, Sandalcioglu IE, Neyazi B, Moritz T, Rossig C, Altvater B, Falk CS, Abken H, Morgan MA, and Schambach A (2021). Generation of an NFkappaB-Driven Alpharetroviral "All-in-One" Vector Construct as a Potent Tool for CAR NK Cell Therapy. Front Immunol12, 751138. doi:10.3389/fimmu.2021.751138.
  • Ruegenberg S, Mayr F, Atanassov I, Baumann U, and Denzel MS (2021). Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1. Nat Commun12, 2176. doi:10.1038/s41467-021-22320-y.
  • Sanchez-Ruiz M, Iorgu AM, Kuster F, Hellmich M, Brunn A, and Deckert M (2021). CD8 T cell-Derived Perforin and TNF-alpha Are Crucial Mediators of Neuronal Destruction in Experimental Autoimmune Enteric Ganglionitis. Am J Pathol191, 1064-1076. doi:10.1016/j.ajpath.2021.02.021.
  • Sankowski R, Ahmari J, Mezo C, Hrabe de Angelis AL, Fuchs V, Utermohlen O, Buch T, Blank T, Gomez de Aguero M, Macpherson AJ, and Erny D (2021). Commensal microbiota divergently affect myeloid subsets in the mammalian central nervous system during homeostasis and disease. EMBO J40, e108605. doi:10.15252/embj.2021108605.
  • Santini L, Halbritter F, Titz-Teixeira F, Suzuki T, Asami M, Ma X, Ramesmayer J, Lackner A, Warr N, Pauler F, Hippenmeyer S, Laue E, Farlik M, Bock C, Beyer A, Perry ACF, and Leeb M (2021). Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3. Nat Commun12(1), 3804. doi:10.1038/s41467-021-23510-4.
  • Schafer M, Korber MI, Vimalathasan R, Mauri V, Iliadis C, Metze C, Ten Freyhaus H, Baldus S, Polidori MC, and Pfister R (2021). Risk Stratification of Patients Undergoing Percutaneous Repair of Mitral and Tricuspid Valves Using a Multidimensional Geriatric Assessment. Circ Cardiovasc Qual Outcomes14, e007624. doi:10.1161/CIRCOUTCOMES.120.007624.
  • Schaufler D, Ast DF, Tumbrink HL, Abedpour N, Maas L, Schwabe AE, Spille I, Lennartz S, Fassunke J, Aldea M, Besse B, Planchard D, Nogova L, Michels S, Kobe C, Persigehl T, Westphal T, Koleczko S, Fischer R, Weber JP, Altmuller J, Thomas RK, Merkelbach-Bruse S, Gautschi O, Mezquita L, Buttner R, Wolf J, Peifer M, Bragelmann J, Scheffler M, and Sos ML (2021). Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer. NPJ Precis Oncol5, 102. doi:10.1038/s41698-021-00241-9.
  • Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleineruschkamp F, Oh J, Godefroid N, Eltan M, Guran T, Burtey S, Parotte MC, Konig J, Braun A, Bos C, Ibars Serra M, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altmuller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers N, Konrad M, and de Baaij JHF (2021). mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy. J Am Soc Nephrol32, 2885-2899. doi:10.1681/ASN.2021030333.
  • Schlusche AK, Vay SU, Kleinenkuhnen N, Sandke S, Campos-Martin R, Florio M, Huttner W, Tresch A, Roeper J, Rueger MA, Jakovcevski I, Stockebrand M, and Isbrandt D (2021). Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice. Proc Natl Acad Sci U S A118. doi:10.1073/pnas.2009393118.
  • Schmelz K, Toedling J, Huska M, Cwikla MC, Kruetzfeldt LM, Proba J, Ambros PF, Ambros IM, Boral S, Lodrini M, Chen CY, Burkert M, Guergen D, Szymansky A, Astrahantseff K, Kuenkele A, Haase K, Fischer M, Deubzer HE, Hertwig F, Hundsdoerfer P, Henssen AG, Schwarz RF, Schulte JH, and Eggert A (2021). Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions. Nat Commun12, 6804. doi:10.1038/s41467-021-26870-z.
  • Schmidt J, Schreiber G, Altmuller J, Thiele H, Nurnberg P, Li Y, Kaulfuss S, Funke R, Wilken B, Yigit G, and Wollnik B (2021). Familial cleft tongue caused by a unique translation initiation codon variant in TP63. Eur J Hum Genet. doi:10.1038/s41431-021-00967-x.
  • Schmidt J, Goergens J, Pochechueva T, Kotter A, Schwenzer N, Sitte M, Werner G, Altmuller J, Thiele H, Nurnberg P, Isensee J, Li Y, Muller C, Leube B, Reinhardt HC, Hucho T, Salinas G, Helm M, Jachimowicz RD, Wieczorek D, Kohl T, Lehnart SE, Yigit G, and Wollnik B (2021). Biallelic variants in YRDC cause a developmental disorder with progeroid features. Hum Genet140, 1679-1693. doi:10.1007/s00439-021-02347-3.
  • Schrittenlocher S, Grass C, Dietlein T, Lappas A, Matthaei M, Cursiefen C, and Bachmann B (2021). Graft survival of Descemet membrane endothelial keratoplasty (DMEK) in corneal endothelial decompensation after glaucoma surgery. Graefes Arch Clin Exp Ophthalmol. doi:10.1007/s00417-021-05506-4.
  • Schroder S, Li Y, Yigit G, Altmuller J, Bader I, Bevot A, Biskup S, Dreha-Kulaczewski S, Christoph Korenke G, Kottke R, Mayr JA, Preisel M, Toelle SP, Wente-Schulz S, Wortmann SB, Hahn H, Boltshauser E, Uhmann A, Wollnik B, and Brockmann K (2021). Heterozygous truncating variants in SUFU cause congenital ocular motor apraxia. Genet Med23, 341-351. doi:10.1038/s41436-020-00979-w.
  • Schunke H, Gobel U, Dikic I, and Pasparakis M (2021). OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun12, 5912. doi:10.1038/s41467-021-25945-1.
  • Schutzmann MP, Hasecke F, Bachmann S, Zielinski M, Hansch S, Schroder GF, Zempel H, and Hoyer W (2021). Endo-lysosomal Abeta concentration and pH trigger formation of Abeta oligomers that potently induce Tau missorting. Nat Commun12, 4634. doi:10.1038/s41467-021-24900-4.
  • Schweitzer F, Goereci Y, Franke C, Silling S, Bosl F, Maier F, Heger E, Deiman B, Pruss H, Onur OA, Klein F, Fink GR, Di Cristanziano V, and Warnke C (2022). Cerebrospinal Fluid Analysis Post-COVID-19 Is Not Suggestive of Persistent Central Nervous System Infection. Ann Neurol91, 150-157. doi:10.1002/ana.26262.
  • Seier JA, Reinhardt J, Saraf K, Ng SS, Layer JP, Corvino D, Althoff K, Giordano FA, Schramm A, Fischer M, and Holzel M (2021). Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma. J Immunother Cancer9. doi:10.1136/jitc-2020-001335.
  • Shein AMS, Wannigama DL, Higgins PG, Hurst C, Abe S, Hongsing P, Chantaravisoot N, Saethang T, Luk-In S, Liao T, Nilgate S, Rirerm U, Kueakulpattana N, Laowansiri M, Srisakul S, Muhummudaree N, Techawiwattanaboon T, Gan L, Xu C, Kupwiwat R, Phattharapornjaroen P, Rojanathanes R, Leelahavanichkul A, and Chatsuwan T (2021). Novel colistin-EDTA combination for successful eradication of colistin-resistant Klebsiella pneumoniae catheter-related biofilm infections. Sci Rep11, 21676. doi:10.1038/s41598-021-01052-5.
  • Silva-Pinheiro P, Pardo-Hernandez C, Reyes A, Tilokani L, Mishra A, Cerutti R, Li S, Rozsivalova DH, Valenzuela S, Dogan SA, Peter B, Fernandez-Silva P, Trifunovic A, Prudent J, Minczuk M, Bindoff L, Macao B, Zeviani M, Falkenberg M, and Viscomi C (2021). DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion. Nucleic Acids Res49, 5230-5248. doi:10.1093/nar/gkab282.
  • Sofiadis K, Josipovic N, Nikolic M, Kargapolova Y, Ubelmesser N, Varamogianni-Mamatsi V, Zirkel A, Papadionysiou I, Loughran G, Keane J, Michel A, Gusmao EG, Becker C, Altmuller J, Georgomanolis T, Mizi A, and Papantonis A (2021). HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence. Mol Syst Biol17, e9760. doi:10.15252/msb.20209760.
  • Spiegel J, Cuesta SM, Adhikari S, Hansel-Hertsch R, Tannahill D, and Balasubramanian S (2021). G-quadruplexes are transcription factor binding hubs in human chromatin. Genome Biol22, 117. doi:10.1186/s13059-021-02324-z.
  • Sprute R, Cornely OA, Chen SC, Seidel D, Schuetz AN, and Zhang SX (2021). All You Need To Know and More about the Diagnosis and Management of Rare Yeast Infections. mBio12, e0159421. doi:10.1128/mBio.01594-21.
  • Sprute R, Jergas H, Olmez A, Alawbathani S, Karasoy H, Dafsari HS, Becker K, Daimaguler HS, Nurnberg P, Muntoni F, Topaloglu H, Uyanik G, and Cirak S (2021). Genotype-phenotype correlation in seven motor neuron disease families with novel ALS2 mutations. Am J Med Genet A185, 344-354. doi:10.1002/ajmg.a.61951.
  • Sprute R, Salmanton-Garcia J, Sal E, Malaj X, Falces-Romero I, Hatvani L, Heinemann M, Klimko N, Lopez-Soria L, Meletiadis J, Shruti M, Steinmann J, Seidel D, Cornely OA, and Stemler J (2021). Characterization and outcome of invasive infections due to Paecilomyces variotii: analysis of patients from the FungiScope(R) registry and literature reports. J Antimicrob Chemother76, 765-774. doi:10.1093/jac/dkaa481.
  • Sprute R, Salmanton-Garcia J, Sal E, Malaj X, Racil Z, Ruiz de Alegria Puig C, Falces-Romero I, Barac A, Desoubeaux G, Kindo AJ, Morris AJ, Pelletier R, Steinmann J, Thompson GR, Cornely OA, Seidel D, Stemler J, and FungiScope EIWG (2021). Invasive infections with Purpureocillium lilacinum: clinical characteristics and outcome of 101 cases from FungiScope(R) and the literature. J Antimicrob Chemother76, 1593-1603. doi:10.1093/jac/dkab039.
  • Stielow B, Zhou Y, Cao Y, Simon C, Pogoda HM, Jiang J, Ren Y, Phanor SK, Rohner I, Nist A, Stiewe T, Hammerschmidt M, Shi Y, Bulyk ML, Wang Z, and Liefke R (2021). The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv7. doi:10.1126/sciadv.abf2229.
  • Stoffel W, Binczek E, Schmidt-Soltau I, Brodesser S, and Wegner I (2021). High fat / high cholesterol diet does not provoke atherosclerosis in the omega3-and omega6-polyunsaturated fatty acid synthesis-inactivated Delta6-fatty acid desaturase-deficient mouse. Mol Metab54, 101335. doi:10.1016/j.molmet.2021.101335.
  • Stuckenschneider T, Abeln V, Foitschik T, Abel T, Polidori MC, and Struder HK (2021). Disease-inclusive exercise classes improve physical fitness and reduce depressive symptoms in individuals with and without Parkinson's disease-A feasibility study. Brain Behav11, e2352. doi:10.1002/brb3.2352.
  • Stussel LG, Hollstein R, Laugsch M, Hochfeld LM, Welzenbach J, Schroder J, Thieme F, Ishorst N, Romero RO, Weinhold L, Hess T, Gehlen J, Mostowska A, Heilmann-Heimbach S, Mangold E, Rada-Iglesias A, Knapp M, Schaaf CP, and Ludwig KU (2021). MiRNA-149 as a Candidate for Facial Clefting and Neural Crest Cell Migration. J Dent Res, 220345211038203. doi:10.1177/00220345211038203.
  • Suarez I, Rohr S, Stecher M, Lehmann C, Winter S, Jung N, Priesner V, Berger M, Wyen C, Augustin M, Malin JJ, Fischer J, Horn C, Neuhann F, Pusken M, Plum G, Fatkenheuer G, and Rybniker J (2021). Plasma interferon-gamma-inducible protein 10 (IP-10) levels correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis. Infection49, 437-445. doi:10.1007/s15010-020-01541-1.
  • Tain LS, Sehlke R, Meilenbrock RL, Leech T, Paulitz J, Chokkalingam M, Nagaraj N, Gronke S, Frohlich J, Atanassov I, Mann M, Beyer A, and Partridge L (2021). Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. Elife10. doi:10.7554/eLife.67275.
  • Takeshita LY, Davidsen PK, Herbert JM, Antczak P, Hesselink MKC, Schrauwen P, Weisnagel SJ, Robbins JM, Gerszten RE, Ghosh S, Sarzynski MA, Bouchard C, and Falciani F (2021). Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training. Sci Rep11, 23314. doi:10.1038/s41598-021-98792-1.
  • Talyan S, Filipow S, Ignarski M, Smieszek M, Chen H, Kuhne L, Butt L, Gobel H, Hoyer-Allo KJR, Koehler FC, Altmuller J, Brinkkotter P, Schermer B, Benzing T, Kann M, Muller RU, and Dieterich C (2021). CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease. Cells10. doi:10.3390/cells10030692.
  • Tan JHJ, Kong SL, Tai JA, Poh HM, Yao F, Sia YY, Lim EKH, Takano AM, Tan DS, Javed A, and Hillmer AM (2021). Experimental and bioinformatics considerations in cancer application of single cell genomics. Comput Struct Biotechnol J19, 343-354. doi:10.1016/j.csbj.2020.12.021.
  • Tayem R, Niemann C, Pesch M, Morgner J, Niessen CM, Wickstrom SA, and Aumailley M (2021). Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs. J Invest Dermatol141, 2602-2610 e2603. doi:10.1016/j.jid.2021.04.008.
  • Thalheim T, Siebert S, Quaas M, Herberg M, Schweiger MR, Aust G, and Galle J (2021). Epigenetic Drifts during Long-Term Intestinal Organoid Culture. Cells10. doi:10.3390/cells10071718.
  • Thelen M, Wennhold K, Lehmann J, Garcia-Marquez M, Klein S, Kochen E, Lohneis P, Lechner A, Wagener-Ryczek S, Plum PS, Velazquez Camacho O, Pfister D, Dorr F, Heldwein M, Hekmat K, Beutner D, Klussmann JP, Thangarajah F, Ratiu D, Malter W, Merkelbach-Bruse S, Bruns CJ, Quaas A, von Bergwelt-Baildon M, and Schlosser HA (2021). Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy. NPJ Precis Oncol5, 52. doi:10.1038/s41698-021-00196-x.
  • Theobald SJ, Grab J, Fritsch M, Suarez I, Eisfeld HS, Winter S, Koch M, Holscher C, Pasparakis M, Kashkar H, and Rybniker J (2021). Gasdermin D mediates host cell death but not interleukin-1beta secretion in Mycobacterium tuberculosis-infected macrophages. Cell Death Discov7, 327. doi:10.1038/s41420-021-00716-5.
  • Theobald SJ, Simonis A, Georgomanolis T, Kreer C, Zehner M, Eisfeld HS, Albert MC, Chhen J, Motameny S, Erger F, Fischer J, Malin JJ, Grab J, Winter S, Pouikli A, David F, Boll B, Koehler P, Vanshylla K, Gruell H, Suarez I, Hallek M, Fatkenheuer G, Jung N, Cornely OA, Lehmann C, Tessarz P, Altmuller J, Nurnberg P, Kashkar H, Klein F, Koch M, and Rybniker J (2021). Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. EMBO Mol Med13, e14150. doi:10.15252/emmm.202114150.
  • Tholking G, Filensky B, Jehn U, Schutte-Nutgen K, Koch R, Kurschat C, Pavenstadt H, Suwelack B, Reuter S, and Kuypers D (2021). Increased renal function decline in fast metabolizers using extended-release tacrolimus after kidney transplantation. Sci Rep11, 15606. doi:10.1038/s41598-021-95201-5.
  • Thomassen JC, Trojan T, Walz M, Vohlen C, Fink G, Rietschel E, Alejandre Alcazar MA, and van Koningsbruggen-Rietschel S (2021). Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-beta1 are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa. ERJ Open Res7. doi:10.1183/23120541.00636-2020.
  • Thues C, Valadas JS, Deaulmerie L, Geens A, Chouhan AK, Duran-Romana R, Schymkowitz J, Rousseau F, Bartusel M, Rehimi R, Rada-Iglesias A, Verstreken P, and Van Esch H (2021). MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome. Sci Rep11, 4976. doi:10.1038/s41598-021-83771-3.
  • Tobys D, Kowalski LM, Cziudaj E, Muller S, Zentis P, Pach E, Zigrino P, Blaeske T, and Honing S (2021). Inhibition of clathrin-mediated endocytosis by knockdown of AP-2 leads to alterations in the plasma membrane proteome. Traffic22, 6-22. doi:10.1111/tra.12770.
  • Tognetti M, Gabor A, Yang M, Cappelletti V, Windhager J, Rueda OM, Charmpi K, Esmaeilishirazifard E, Bruna A, de Souza N, Caldas C, Beyer A, Picotti P, Saez-Rodriguez J, and Bodenmiller B (2021). Deciphering the signaling network of breast cancer improves drug sensitivity prediction. Cell Syst12(5), 401-418 e12. doi:10.1016/j.cels.2021.04.002.
  • Tosetti B, Ward B, Grumme D, Herb M, Schramm M, Utermohlen O, Heukamp LC, Kronke M, and Krut O (2021). NOX2 Deficiency Permits Sustained Survival of S. aureus in Macrophages and Contributes to Severity of Infection. Front Immunol12, 633629. doi:10.3389/fimmu.2021.633629.
  • Toutah K, Nawar N, Timonen S, Sorger H, Raouf YS, Bukhari S, von Jan J, Ianevski A, Gawel JM, Olaoye OO, Geletu M, Abdeldayem A, Israelian J, Radu TB, Sedighi A, Bhatti MN, Hassan MM, Manaswiyoungkul P, Shouksmith AE, Neubauer HA, de Araujo ED, Aittokallio T, Kramer OH, Moriggl R, Mustjoki S, Herling M, and Gunning PT (2021). Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia. J Med Chem64, 8486-8509. doi:10.1021/acs.jmedchem.1c00420.
  • Tzaridis T, Bachurski D, Liu S, Surmann K, Babatz F, Gesell Salazar M, Volker U, Hallek M, Herrlinger U, Vorberg I, Coch C, Reiners KS, and Hartmann G (2021). Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications. Int J Mol Sci22. doi:10.3390/ijms22179211.
  • Ucal M, Maurer C, Etschmaier V, Hamberger D, Grunbacher G, Togl L, Roosen MJ, Molcanyi M, Vorholt D, Hatay FF, Hescheler J, Pallasch C, Schafer U, and Patz S (2021). Inflammatory Pre-Conditioning of Adipose-Derived Stem Cells with Cerebrospinal Fluid from Traumatic Brain Injury Patients Alters the Immunomodulatory Potential of ADSC Secretomes. J Neurotrauma38, 2311-2322. doi:10.1089/neu.2020.7017.
  • Uzun S, Korkmaz Y, Wuerdemann N, Arolt C, Puladi B, Siefer OG, Donmez HG, Hufbauer M, Akgul B, Klussmann JP, and Huebbers CU (2021). Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns. Cancers (Basel)13. doi:10.3390/cancers13205221.
  • Vanshylla K, Di Cristanziano V, Kleipass F, Dewald F, Schommers P, Gieselmann L, Gruell H, Schlotz M, Ercanoglu MS, Stumpf R, Mayer P, Zehner M, Heger E, Johannis W, Horn C, Suarez I, Jung N, Salomon S, Eberhardt KA, Gathof B, Fatkenheuer G, Pfeifer N, Eggeling R, Augustin M, Lehmann C, and Klein F (2021). Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans. Cell Host Microbe29, 917-929 e914. doi:10.1016/j.chom.2021.04.015.
  • Vanshylla K, Fan C, Wunsch M, Poopalasingam N, Meijers M, Kreer C, Kleipass F, Ruchnewitz D, Ercanoglu MS, Gruell H, Munn F, Pohl K, Janicki H, Nolden T, Bartl S, Stein SC, Augustin M, Dewald F, Gieselmann L, Schommers P, Schulz TF, Sander LE, Koch M, Luksza M, Lassig M, Bjorkman PJ, and Klein F (2021). Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers. Cell Host Microbe. doi:10.1016/j.chom.2021.12.010.
  • Vanshylla K, Held K, Eser TM, Gruell H, Kleipass F, Stumpf R, Jain K, Weiland D, Munch J, Gruttner B, Geldmacher C, and Klein F (2021). CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention. Vaccines (Basel)9. doi:10.3390/vaccines9030198.
  • van Tilburg CM, Pfaff E, Pajtler KW, Langenberg KPS, Fiesel P, Jones BC, Balasubramanian GP, Stark S, Johann PD, Blattner-Johnson M, Schramm K, Dikow N, Hirsch S, Sutter C, Grund K, von Stackelberg A, Kulozik AE, Lissat A, Borkhardt A, Meisel R, Reinhardt D, Klusmann JH, Fleischhack G, Tippelt S, von Schweinitz D, Schmid I, Kramm CM, Bueren AO, Calaminus G, Vorwerk P, Graf N, Westermann F, Fischer M, Eggert A, Burkhardt B, Wößmann W, Nathrath M, Hecker-Nolting S, Frühwald MC, Schneider DT, Brecht IB, Ketteler P, Fulda S, Koscielniak E, Meister MT, Scheer M, Hettmer S, Schwab M, Tremmel R, Øra I, Hutter C, Gerber NU, Lohi O, Kazanowska B, Kattamis A, Filippidou M, Goemans B, Zwaan CM, Milde T, Jäger N, Wolf S, Reuss D, Sahm F, von Deimling A, Dirksen U, Freitag A, Witt R, Lichter P, Kopp-Schneider A, Jones DTW, Molenaar JJ, Capper D, Pfister SM, Witt O (2021). The pediatric precision oncology INFORM registry: clinical outcome and benefit for patients with very high-evidence targets. Cancer Discov 11(11), 2764-2779. doi: 10.1158/2159-8290.CD-21-0094. 
  • Voggel J, Lubomirov L, Lechner F, Fink G, Nusken E, Wohlfarth M, Pfitzer G, Shah-Hosseini K, Hellmich M, Alejandre Alcazar MA, Dotsch J, and Nusken KD (2021). Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction. Am J Physiol Renal Physiol321, F93-F105. doi:10.1152/ajprenal.00653.2020.
  • Vogtmann R, Heupel J, Herse F, Matin M, Hagmann H, Bendix I, Kraker K, Dechend R, Winterhager E, Kimmig R, Koninger A, and Gellhaus A (2021). Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model. Hypertension78, 1067-1079. doi:10.1161/HYPERTENSIONAHA.121.17567.
  • Vohlen C, Mohr J, Fomenko A, Kuiper-Makris C, Grzembke T, Aydogmus R, Wilke R, Hirani D, Dotsch J, and Alejandre Alcazar MA (2021). Dynamic Regulation of GH-IGF1 Signaling in Injury and Recovery in Hyperoxia-Induced Neonatal Lung Injury. Cells10. doi:10.3390/cells10112947.
  • Wang D, Liu C, Liu H, Meng Y, Lin F, Gu Y, Wang H, Shang M, Tong C, Sachinidis A, Ying Q, Li L, and Peng L (2021). ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling. Stem Cells39, 443-457. doi:10.1002/stem.3328.
  • Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Handler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmuller J, Mishra N, Bernardes JP, Kramer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S, Study C-A, Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nurnberg P, Riess O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T, Deutsche C-OI, Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, and Schultze JL (2021). Swarm Learning for decentralized and confidential clinical machine learning. Nature594, 265-270. doi:10.1038/s41586-021-03583-3.
  • Welcker D, Stein C, Feitosa NM, Armistead J, Zhang JL, Lutke S, Kleinridders A, Bruning JC, Eming SA, Sengle G, Niehoff A, Bloch W, and Hammerschmidt M (2021). Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions. Sci Rep11, 17926. doi:10.1038/s41598-021-96824-4.
  • Welker A, Hennes M, Bender N, Cronenberg T, Schneider G, and Maier B (2021). Spatiotemporal dynamics of growth and death within spherical bacterial colonies. Biophys J120, 3418-3428. doi:10.1016/j.bpj.2021.06.022.
  • Welzenbach J, Hammond NL, Nikolić M, Thieme F, Ishorst N, Leslie EJ, Weinberg SM, Beaty TH, Marazita ML, Mangold E, Knapp M, Cotney J, Rada-Iglesias A, Dixon MJ, Ludwig KU. Integrative approaches generate insights into the architecture of non-syndromic cleft lip with or without cleft palate. HGG Adv. 2021 Jun 8;2(3):100038. doi: 10.1016/j.xhgg.2021.100038. eCollection 2021 Jul 8. PMID: 35047836
  • Weng PL, Majmundar AJ, Khan K, Lim TY, Shril S, Jin G, Musgrove J, Wang M, Ahram DF, Aggarwal VS, Bier LE, Heinzen EL, Onuchic-Whitford AC, Mann N, Buerger F, Schneider R, Deutsch K, Kitzler TM, Klambt V, Kolb A, Mao Y, Moufawad El Achkar C, Mitrotti A, Martino J, Beck BB, Altmuller J, Benz MR, Yano S, Mikati MA, Gunduz T, Cope H, Shashi V, Undiagnosed Diseases N, Trachtman H, Bodria M, Caridi G, Pisani I, Fiaccadori E, AbuMaziad AS, Martinez-Agosto JA, Yadin O, Zuckerman J, Kim A, Center UCG, John-Kroegel U, Tyndall AV, Parboosingh JS, Innes AM, Bierzynska A, Koziell AB, Muorah M, Saleem MA, Hoefele J, Riedhammer KM, Gharavi AG, Jobanputra V, Pierce-Hoffman E, Seaby EG, O'Donnell-Luria A, Rehm HL, Mane S, D'Agati VD, Pollak MR, Ghiggeri GM, Lifton RP, Goldstein DB, Davis EE, Hildebrandt F, and Sanna-Cherchi S (2021). De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis. Am J Hum Genet108, 357-367. doi:10.1016/j.ajhg.2021.01.008.
  • Wennhold K, Thelen M, Lehmann J, Schran S, Preugszat E, Garcia-Marquez M, Lechner A, Shimabukuro-Vornhagen A, Ercanoglu MS, Klein F, Thangarajah F, Eidt S, Loser H, Bruns C, Quaas A, von Bergwelt-Baildon M, and Schlosser HA (2021). CD86(+) Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses. Cancer Immunol Res9, 1098-1108. doi:10.1158/2326-6066.CIR-20-0949.
  • Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nuchel J, Popovic M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Bruning JC, Trifunovic A, and Eming SA (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab33, 2398-2414 e2399. doi:10.1016/j.cmet.2021.10.004.
  • Willms A, Schupp H, Poelker M, Adawy A, Debus JF, Hartwig T, Krichel T, Fritsch J, Singh S, Walczak H, von Karstedt S, Schafer H, and Trauzold A (2021). TRAIL-receptor 2-a novel negative regulator of p53. Cell Death Dis12, 757. doi:10.1038/s41419-021-04048-1.
  • Wolber P, Nachtsheim L, Hoffmann F, Klussmann JP, Meyer M, von Eggeling F, Guntinas-Lichius O, Quaas A, and Arolt C (2021). Trophoblast Cell Surface Antigen 2 (Trop-2) Protein is Highly Expressed in Salivary Gland Carcinomas and Represents a Potential Therapeutic Target. Head Neck Pathol15, 1147-1155. doi:10.1007/s12105-021-01325-5.
  • Wu F, Fan J, He Y, Xiong A, Yu J, Li Y, Zhang Y, Zhao W, Zhou F, Li W, Zhang J, Zhang X, Qiao M, Gao G, Chen S, Chen X, Li X, Hou L, Wu C, Su C, Ren S, Odenthal M, Buettner R, Fang N, and Zhou C (2021). Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nat Commun12, 2540. doi:10.1038/s41467-021-22801-0.
  • Wunsch M, Aschemeier D, Heger E, Ehrentraut D, Kruger J, Hufbauer M, Syed AS, Horemheb-Rubio G, Dewald F, Fish I, Schlotz M, Gruell H, Augustin M, Lehmann C, Kaiser R, Knops E, Silling S, and Klein F (2021). Safe and effective pool testing for SARS-CoV-2 detection. J Clin Virol145, 105018. doi:10.1016/j.jcv.2021.105018.
  • Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Bruning JC, and Hausen AC (2021). Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat Commun12, 5249. doi:10.1038/s41467-021-25380-2.
  • Ye L, Ji H, Liu J, Tu CH, Kappl M, Koynov K, Vogt J, and Butt HJ (2021). Carbon Nanotube-Hydrogel Composites Facilitate Neuronal Differentiation While Maintaining Homeostasis of Network Activity. Adv Mater33, e2102981. doi:10.1002/adma.202102981.
  • Young N, Asif M, Jackson M, Fernandez-Mayoralas DM, de la Pena MJ, Calleja-Perez B, Alvarez S, Hunter-Featherstone E, Noegel AA, Hohne W, Nurnberg P, Obara B, Hussain MS, Karakesisoglou I, and Fernandez-Jaen A (2021). Biallelic SYNE2 Missense Mutations Leading to Nesprin-2 Giant Hypo-Expression Are Associated with Intellectual Disability and Autism. Genes (Basel)12. doi:10.3390/genes12091294.
  • Zampetidis CP, Galanos P, Angelopoulou A, Zhu Y, Polyzou A, Karamitros T, Kotsinas A, Lagopati N, Mourkioti I, Mirzazadeh R, Polyzos A, Garnerone S, Mizi A, Gusmao EG, Sofiadis K, Gal Z, Larsen DH, Pefani DE, Demaria M, Tsirigos A, Crosetto N, Maya-Mendoza A, Papaspyropoulos A, Evangelou K, Bartek J, Papantonis A, and Gorgoulis VG (2021). A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization. Mol Cell81, 4907-4923 e4908. doi:10.1016/j.molcel.2021.10.017.
  • Zhang S, Ubelmesser N, Josipovic N, Forte G, Slotman JA, Chiang M, Gothe HJ, Gusmao EG, Becker C, Altmuller J, Houtsmuller AB, Roukos V, Wendt KS, Marenduzzo D, and Papantonis A (2021). RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis. Sci Adv7, eabg8205. doi:10.1126/sciadv.abg8205.
  • Zhang W, Schonberg A, Hamdorf M, Georgiev T, Cursiefen C, and Bock F (2021). Preincubation of donor tissue with a VEGF cytokine trap promotes subsequent high-risk corneal transplant survival. Br J Ophthalmol. doi:10.1136/bjophthalmol-2021-319745.
  • Zimmermann PH, Stuut M, Wuerdemann N, Mollenhoff K, Suchan M, Eckel H, Wolber P, Sharma SJ, Kammerer F, Langer C, Wittekindt C, Wagner S, Kremer B, Speel EJM, and Klussmann JP (2021). Upfront Surgery vs. Primary Chemoradiation in an Unselected, Bicentric Patient Cohort with Oropharyngeal Squamous Cell Carcinoma-A Matched-Pair Analysis. Cancers (Basel)13. doi:10.3390/cancers13215265.
  • Adamo CS, Zuk AV, and Sengle G (2021). The fibrillin microfibril/elastic fibre network: A critical extracellular supramolecular scaffold to balance skin homoeostasis. Exp Dermatol30, 25-37. doi:10.1111/exd.14191.
  • Balaji H, Demers I, Wuerdemann N, Schrijnder J, Kremer B, Klussmann JP, Huebbers CU, and Speel EM (2021). Causes and Consequences of HPV Integration in Head and Neck Squamous Cell Carcinomas: State of the Art. Cancers (Basel)13. doi:10.3390/cancers13164089.
  • Bell M, Bachmann S, Klimek J, Langerscheidt F, and Zempel H (2021). Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS. Neuroscience461, 155-171. doi:10.1016/j.neuroscience.2021.01.041.
  • Benzing T, and Salant D (2021). Insights into Glomerular Filtration and Albuminuria. N Engl J Med384, 1437-1446. doi:10.1056/NEJMra1808786.
  • Beck L, Witt R, Nesper-Brock M, Milde T, Hettmer S, Frühwald MC, Rössig C, Fischer M, Reinhardt D, Taylor LA, Riedel C, Witt O, van Tilburg CM (2021). A study of regulatory challenges of paediatric oncology phase I/II trial submissions and guidance of protocol development. Clin Pharmacol Ther 110(4): 1025-1037. doi:10.1002/cpt.2319.
  • Bhat H, Ali M, and Hamdan TA (2021). Arenavirus Therapy in Combination with Checkpoint Blockade as an Effective Way for Better Tumour Clearance. Cell Physiol Biochem55, 726-738. doi:10.33594/000000472.
  • Braun T, Dechow A, Friedrich G, Seifert M, Stachelscheid J, and Herling M (2021). Advanced Pathogenetic Concepts in T-Cell Prolymphocytic Leukemia and Their Translational Impact. Front Oncol11, 775363. doi:10.3389/fonc.2021.775363.
  • Correns A, Zimmermann LA, Baldock C, and Sengle G (2021). BMP antagonists in tissue development and disease. Matrix Biol Plus11, 100071. doi:10.1016/j.mbplus.2021.100071.
  • Cursiefen C, and Hos D (2021). Cutting Edge: Novel Treatment Options Targeting Corneal Neovascularization to Improve High-Risk Corneal Graft Survival. Cornea40, 1512-1518. doi:10.1097/ICO.0000000000002736.
  • da Silva PFL, and Schumacher B (2021). Principles of the Molecular and Cellular Mechanisms of Aging. J Invest Dermatol141, 951-960. doi:10.1016/j.jid.2020.11.018.
  • Daliri K, Pfannkuche K, and Garipcan B (2021). Effects of physicochemical properties of polyacrylamide (PAA) and (polydimethylsiloxane) PDMS on cardiac cell behavior. Soft Matter17, 1156-1172. doi:10.1039/d0sm01986k.
  • Dias Gomes M, and Iden S (2021). Orchestration of tissue-scale mechanics and fate decisions by polarity signalling. EMBO J40, e106787. doi:10.15252/embj.2020106787.
  • Ding X, Kakanj P, Leptin M, and Eming SA (2021). Regulation of the Wound Healing Response during Aging. J Invest Dermatol141, 1063-1070. doi:10.1016/j.jid.2020.11.014.
  • Ehren R, Benz MR, Brinkkotter PT, Dotsch J, Eberl WR, Gellermann J, Hoyer PF, Jordans I, Kamrath C, Kemper MJ, Latta K, Muller D, Oh J, Tonshoff B, Weber S, Weber LT, and German Society for Pediatric N (2021). Pediatric idiopathic steroid-sensitive nephrotic syndrome: diagnosis and therapy -short version of the updated German best practice guideline (S2e) - AWMF register no. 166-001, 6/2020. Pediatr Nephrol36, 2971-2985. doi:10.1007/s00467-021-05135-3.
  • Eming SA, Murray PJ, and Pearce EJ (2021). Metabolic orchestration of the wound healing response. Cell Metab33, 1726-1743. doi:10.1016/j.cmet.2021.07.017.
  • Fazeli W, Bamborschke D, Moawia A, Bakhtiari S, Tafakhori A, Giersdorf M, Hahn A, Weik A, Kolzter K, Shafiee S, Jin SC, Korber F, Lee-Kirsch MA, Darvish H, Cirak S, Kruer MC, and Koy A (2021). The phenotypic spectrum of PCDH12 associated disorders - Five new cases and review of the literature. Eur J Paediatr Neurol36, 7-13. doi:10.1016/j.ejpn.2021.10.011.
  • Gehring NH, and Roignant JY (2021). Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation. Trends Genet37, 355-372. doi:10.1016/j.tig.2020.10.008.
  • Geueke A, and Niemann C (2021). Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies. Exp Dermatol30, 588-597. doi:10.1111/exd.14303.
  • Gieselmann L, Kreer C, Ercanoglu MS, Lehnen N, Zehner M, Schommers P, Potthoff J, Gruell H, and Klein F (2021). Effective high-throughput isolation of fully human antibodies targeting infectious pathogens. Nat Protoc16, 3639-3671. doi:10.1038/s41596-021-00554-w.
  • Gimpel C, Liebau MC, Schaefer F. „Systematic review on outcomes used in clinical research on autosomal recessive polycystic kidney disease—are patient-centered outcomes our blind spot?“ Pediatric Nephrology, 2021 Dec;36(12):3841-3851. doi: 10.1007/s00467-021-05192-8. 
  • Hackl A, Zed S, Diefenhardt P, Binz-Lotter J, Ehren R, and Weber LT (2021). The role of the immune system in idiopathic nephrotic syndrome. Mol Cell Pediatr8, 18. doi:10.1186/s40348-021-00128-6.
  • Hadrian K, Willenborg S, Bock F, Cursiefen C, Eming SA, and Hos D (2021). Macrophage-Mediated Tissue Vascularization: Similarities and Differences Between Cornea and Skin. Front Immunol12, 667830. doi:10.3389/fimmu.2021.667830.
  • Haumann S, Müller RU, Liebau MC. „Metabolic changes in polycystic kidney disease as a potential target for systemic treatment“; International Journal of Molecular Sciences. 2020, 21(17), 6093; doi.org/10.3390/ijms21176093
  • Hohfeld J, Benzing T, Bloch W, Furst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Kohn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, and Warscheid B (2021). Maintaining proteostasis under mechanical stress. EMBO Rep22, e52507. doi:10.15252/embr.202152507.
  • Hommen F, Bilican S, and Vilchez D (2021). Protein clearance strategies for disease intervention. J Neural Transm (Vienna). doi:10.1007/s00702-021-02431-y.
  • Hoppe S, Jonas C, Wenzel MC, Velazquez Camacho O, Arolt C, Zhao Y, Buttner R, Quaas A, Plum PS, and Hillmer AM (2021). Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma. Cancers (Basel)13. doi:10.3390/cancers13174300.
  • Hou Y, Bock F, Hos D, and Cursiefen C (2021). Lymphatic Trafficking in the Eye: Modulation of Lymphatic Trafficking to Promote Corneal Transplant Survival. Cells10. doi:10.3390/cells10071661.
  • Jais A, and Bruning JC (2021). Arcuate nucleus-dependent regulation of metabolism - pathways to obesity and diabetes mellitus. Endocr Rev. doi:10.1210/endrev/bnab025.
  • Klein I, and Lehmann HC (2021). Pathomechanisms of Paclitaxel-Induced Peripheral Neuropathy. Toxics9. doi:10.3390/toxics9100229.
  • Klinger JR, Chakinala MM, Langleben D, Rosenkranz S, and Sitbon O (2021). Riociguat: Clinical research and evolving role in therapy. Br J Clin Pharmacol87, 2645-2662. doi:10.1111/bcp.14676.
  • Koehler FC, Spath MR, Hoyer-Allo KJR, and Muller RU (2021). Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury. Nephron, 1-5. doi:10.1159/000517733.
  • Kohl S, Habbig S, Weber LT, and Liebau MC (2021). Molecular causes of congenital anomalies of the kidney and urinary tract (CAKUT). Mol Cell Pediatr8, 2. doi:10.1186/s40348-021-00112-0.
  • Kuiper-Makris C, Selle J, Nusken E, Dotsch J, and Alejandre Alcazar MA (2021). Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases. Front Med (Lausanne)8, 667315. doi:10.3389/fmed.2021.667315.
  • Kurschat CE (2021). Fabry disease-what cardiologists can learn from the nephrologist: a narrative review. Cardiovasc Diagn Ther11, 672-682. doi:10.21037/cdt-20-981.
  • Liebau MC (2021). Early clinical management of autosomal recessive polycystic kidney disease. Pediatr Nephrol36, 3561-3570. doi:10.1007/s00467-021-04970-8.
  • Liebau MC, and Mekahli D (2021). Translational research approaches to study pediatric polycystic kidney disease. Mol Cell Pediatr8, 20. doi:10.1186/s40348-021-00131-x.
  • Maier B (2021). How Physical Interactions Shape Bacterial Biofilms. Annu Rev Biophys50, 401-417. doi:10.1146/annurev-biophys-062920-063646.
  • Mayr SJ, Mendel RR, and Schwarz G (2021). Molybdenum cofactor biology, evolution and deficiency. Biochim Biophys Acta Mol Cell Res1868, 118883. doi:10.1016/j.bbamcr.2020.118883.
  • Meggendorfer M, Jobanputra V, Wrzeszczynski KO, Roepman P, de Bruijn E, Cuppen E, Buttner R, Caldas C, Grimmond S, Mullighan CG, Elemento O, Rosenquist R, Schuh A, and Haferlach T (2021). Analytical demands to use whole-genome sequencing in precision oncology. Semin Cancer Biol. doi:10.1016/j.semcancer.2021.06.009.
  • Mirzayi C, Renson A, Genomic Standards C, Massive A, Quality Control S, Zohra F, Elsafoury S, Geistlinger L, Kasselman LJ, Eckenrode K, van de Wijgert J, Loughman A, Marques FZ, MacIntyre DA, Arumugam M, Azhar R, Beghini F, Bergstrom K, Bhatt A, Bisanz JE, Braun J, Bravo HC, Buck GA, Bushman F, Casero D, Clarke G, Collado MC, Cotter PD, Cryan JF, Demmer RT, Devkota S, Elinav E, Escobar JS, Fettweis J, Finn RD, Fodor AA, Forslund S, Franke A, Furlanello C, Gilbert J, Grice E, Haibe-Kains B, Handley S, Herd P, Holmes S, Jacobs JP, Karstens L, Knight R, Knights D, Koren O, Kwon DS, Langille M, Lindsay B, McGovern D, McHardy AC, McWeeney S, Mueller NT, Nezi L, Olm M, Palm N, Pasolli E, Raes J, Redinbo MR, Ruhlemann M, Balfour Sartor R, Schloss PD, Schriml L, Segal E, Shardell M, Sharpton T, Smirnova E, Sokol H, Sonnenburg JL, Srinivasan S, Thingholm LB, Turnbaugh PJ, Upadhyay V, Walls RL, Wilmes P, Yamada T, Zeller G, Zhang M, Zhao N, Zhao L, Bao W, Culhane A, Devanarayan V, Dopazo J, Fan X, Fischer M, Jones W, Kusko R, Mason CE, Mercer TR, Sansone SA, Scherer A, Shi L, Thakkar S, Tong W, Wolfinger R, Hunter C, Segata N, Huttenhower C, Dowd JB, Jones HE, and Waldron L (2021). Reporting guidelines for human microbiome research: the STORMS checklist. Nat Med27, 1885-1892. doi:10.1038/s41591-021-01552-x.
  • Misko A, Mahtani K, Abbott J, Schwarz G, and Atwal P. in GeneReviews((R))   (eds M. P. Adam et al.)  (1993).
  • Nettersheim FS, Picard FSR, Hoyer FF, and Winkels H (2021). Immunotherapeutic Strategies in Cancer and Atherosclerosis-Two Sides of the Same Coin. Front Cardiovasc Med8, 812702. doi:10.3389/fcvm.2021.812702.
  • Ottens F, Franz A, and Hoppe T (2021). Build-UPS and break-downs: metabolism impacts on proteostasis and aging. Cell Death Differ28, 505-521. doi:10.1038/s41418-020-00682-y.
  • Papazoglou P, Peng L, and Sachinidis A (2021). Epigenetic Mechanisms Involved in the Cardiovascular Toxicity of Anticancer Drugs. Front Cardiovasc Med8, 658900. doi:10.3389/fcvm.2021.658900.
  • Persa OD, Koester J, and Niessen CM (2021). Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer. J Invest Dermatol141, 1017-1023. doi:10.1016/j.jid.2020.12.012.
  • Polidori MC, Alves M, Bahat G, Boureau AS, Ozkok S, Pfister R, Pilotto A, Veronese N, Bo M, and Special Interest Group "Cardiovascular Diseases" of the Eu GMS (2021). Atrial fibrillation: a geriatric perspective on the 2020 ESC guidelines. Eur Geriatr Med. doi:10.1007/s41999-021-00537-w.
  • Polidori MC, Sies H, Ferrucci L, and Benzing T (2021). COVID-19 mortality as a fingerprint of biological age. Ageing Res Rev67, 101308. doi:10.1016/j.arr.2021.101308.
  • Polidori MC, Stahl W, and Griffiths HR (2021). Nutritional cognitive neuroscience of aging: Focus on carotenoids and cognitive frailty. Redox Biol44, 101996. doi:10.1016/j.redox.2021.101996.
  • Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tschop MH, Diano S, Bruning JC, and Cota D (2021). POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nat Metab3, 299-308. doi:10.1038/s42255-021-00345-3.
  • Rieckher M, Garinis GA, and Schumacher B (2021). Molecular pathology of rare progeroid diseases. Trends Mol Med27, 907-922. doi:10.1016/j.molmed.2021.06.011.
  • Rinschen MM, and Saez-Rodriguez J (2021). The tissue proteome in the multi-omic landscape of kidney disease. Nat Rev Nephrol17, 205-219. doi:10.1038/s41581-020-00348-5.
  • Rodriguez-Marquez E, Meumann N, and Buning H (2021). Adeno-associated virus (AAV) capsid engineering in liver-directed gene therapy. Expert Opin Biol Ther21, 749-766. doi:10.1080/14712598.2021.1865303.
  • Rosenquist R, Cuppen E, Buettner R, Caldas C, Dreau H, Elemento O, Frederix G, Grimmond S, Haferlach T, Jobanputra V, Meggendorfer M, Mullighan CG, Wordsworth S, and Schuh A (2021). Clinical utility of whole-genome sequencing in precision oncology. Semin Cancer Biol. doi:10.1016/j.semcancer.2021.06.018.
  • Rust K, and Wodarz A (2021). Transcriptional Control of Apical-Basal Polarity Regulators. Int J Mol Sci22. doi:10.3390/ijms222212340.
  • Sawant M, Hinz B, Schonborn K, Zeinert I, Eckes B, Krieg T, and Schuster R (2021). A story of fibers and stress: Matrix-embedded signals for fibroblast activation in the skin. Wound Repair Regen29, 515-530. doi:10.1111/wrr.12950.
  • Schlereth SL, Hos D, Matthaei M, Hamrah P, Schmetterer L, O'Leary O, Ullmer C, Horstmann J, Bock F, Wacker K, Schroder H, Notara M, Haagdorens M, Nuijts R, Dunker SL, Dickman MM, Fauser S, Scholl HPN, Wheeler-Schilling T, and Cursiefen C (2021). New Technologies in Clinical Trials in Corneal Diseases and Limbal Stem Cell Deficiency: Review from the European Vision Institute Special Interest Focus Group Meeting. Ophthalmic Res64, 145-167. doi:10.1159/000509954.
  • Schumacher B, Pothof J, Vijg J, and Hoeijmakers JHJ (2021). The central role of DNA damage in the ageing process. Nature592, 695-703. doi:10.1038/s41586-021-03307-7.
  • Schumacher S, Salmanton-Garcia J, Cornely OA, and Mellinghoff SC (2021). Increasing influenza vaccination coverage in healthcare workers: a review on campaign strategies and their effect. Infection49, 387-399. doi:10.1007/s15010-020-01555-9.
  • Seufert L, Benzing T, Ignarski M, and Muller RU (2021). RNA-binding proteins and their role in kidney disease. Nat Rev Nephrol. doi:10.1038/s41581-021-00497-1.
  • Simonis A, Theobald SJ, Fatkenheuer G, Rybniker J, and Malin JJ (2021). A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2. EMBO Mol Med13, e13105. doi:10.15252/emmm.202013105.
  • Stachelscheid J, Jiang Q, and Herling M (2021). The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A. Cancers (Basel)13. doi:10.3390/cancers13215455.
  • Szczepanowska K, and Trifunovic A (2021). Mitochondrial matrix proteases: quality control and beyond. FEBS J. doi:10.1111/febs.15964.
  • Szczepanowska K, and Trifunovic A (2021). Tune instead of destroy: How proteolysis keeps OXPHOS in shape. Biochim Biophys Acta Bioenerg1862, 148365. doi:10.1016/j.bbabio.2020.148365.
  • Tadepalle N, and Rugarli EI (2021). Lipid Droplets in the Pathogenesis of Hereditary Spastic Paraplegia. Front Mol Biosci8, 673977. doi:10.3389/fmolb.2021.673977.
  • Tammam SN, El Safy S, Ramadan S, Arjune S, Krakor E, and Mathur S (2021). Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2. J Control Release337, 258-284. doi:10.1016/j.jconrel.2021.07.028.
  • Tischkowitz M, Balmana J, Foulkes WD, James P, Ngeow J, Schmutzler R, Voian N, Wick MJ, Stewart DR, Pal T, Practice AP, and Guidelines C (2021). Management of individuals with germline variants in PALB2: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med23, 1416-1423. doi:10.1038/s41436-021-01151-8.
  • Tumbrink HL, Heimsoeth A, and Sos ML (2021). The next tier of EGFR resistance mutations in lung cancer. Oncogene40, 1-11. doi:10.1038/s41388-020-01510-w.
  • Voggel J, Mohr J, Nusken KD, Dotsch J, Nusken E, and Alejandre Alcazar MA (2021). Translational insights into mechanisms and preventive strategies after renal injury in neonates. Semin Fetal Neonatal Med, 101245. doi:10.1016/j.siny.2021.101245.
  • Wirth B (2021). Spinal Muscular Atrophy: In the Challenge Lies a Solution. Trends Neurosci44, 306-322. doi:10.1016/j.tins.2020.11.009.
  • Wolff L, Strathmann EA, Muller I, Mahlich D, Veltman C, Niehoff A, and Wirth B (2021). Plastin 3 in health and disease: a matter of balance. Cell Mol Life Sci78, 5275-5301. doi:10.1007/s00018-021-03843-5.
  • Zimmer-Bensch G, and Zempel H (2021). DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer's, Related Tauopathies and Genetic Tauopathies. Cells10. doi:10.3390/cells10113064.
  • Zimmermann LA, Correns A, Furlan AG, Spanou CES, and Sengle G (2021). Controlling BMP growth factor bioavailability: The extracellular matrix as multi skilled platform. Cell Signal85, 110071. doi:10.1016/j.cellsig.2021.110071.