Prof. Dr. rer. nat. Thomas Langer - Curriculum Vitae

Education and professional career

since 2001: Professor for Genetics
1999: Habilitation and Venia legendi in Biochemistry
1996-2001: Group leader, Collaborative Research Center 194 of the German Research Council, Ludwig-Maximilians-University of Munich
1993-1996: Group leader, Adolf Butenandt Institute for Physiological Chemistry, Ludwig-Maximilians-University of Munich
1992-1993: Visiting scientist at the Memorial Sloan-Kettering Cancer Institute, New York.
1989-1993: Ph.D., Ludwig-Maximilians-University of Munich
1984-1989: Study of Biological Sciences, University of Regensburg

Awards, distinctions and professional activities

2017: Max-Delbrück-Preis
2017: EMBO Global Exchange Lecture Series, China
since 2017: Pro-Dean for Personnel and Finances, Faculty of Mathematics and Natures Sciences, University of Cologne
2016: International Steenbock lecturer, University of Wisconsin
2016: Wilhelm Feldberg prize, UK
since 2016: Senator for Cell and Developmental Biology, German Research Council
2016 - 2020: Core Committee of the Max Planck Society for the Max Planck Institute for Biology of Aging
since 2016: Coordinator, Collaborative Research Center 1218  of the German Research Council, Mitochondrial regulation of cellular function, University of Cologne
2015 - 2020: Reinhart Koselleck Grant, German Research Council
2013 - 2015: Pro-Rector for Research and Junior Scholars of the University of Cologne
2012: Elected member, Leopoldina (German National Academy of Sciences)
2012 - 2015: Steering committee of the Institutional Strategy of the University of Cologne
2011: Elected member, Academy of Sciences and Arts North Rhine-Westphalia
since 2011: Member and Chair of Panel LS3 (Cellular and Developmental Biology) Consolidator Grants of the European Research Council
2010 - 2011: Acting director, Biology Section of the Faculty for Natural Sciences, University of Cologne
2009 - 2014: Advanced Career Grant, European Research Council
2008 - 2014: Max-Planck Fellow, Max-Planck-Institute for Biology of Aging, Cologne
2007: Elected EMBO member
since 2007: Vice coordinator, Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
2007 - 2011: Senator, Faculty of Natural Sciences, University of Cologne
since 2006: Executive board, Graduate School for Biological Sciences, University of Cologne
2005 - 2012: Study section for Biochemistry, Biophysics and Bioinformatics, German Research Council, Bonn
2003 - 2015: Coordinator, Collaborative Research Center 635 of the German Research Council, Posttranslational Control of Protein Function, University of Cologne
2001 - 2009: Steering committee, Center for Molecular Medicine Cologne
2001 - 2005: Ph.D. fellowship selection committee, German Academic Exchange Ser¬vice, Bonn

Selected publications

Vucotic M, Nolte H, König T, Saita S, Ananjew M, Krüger M, Tatsuta T, and Langer T: Acylglycerol kinase mutated in Sengers syndrome is a subunit of the TIM22 protein tanslocase in mitochondria. Mol Cell. (2017), in press.

Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, and Langer T: PARL mediates Smac/DIABLO proteolytic maturation in mitochondria to promote apoptosis. Nat Cell Biol. (2017), 19: 318-28. doi:10.1038/ncb3488.

Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger H-G, Madrenas J, Mühlmeister M, Brandt U, Krüger M, and Langer T: The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. (2016), 17: 1844-56. doi: 10.15252/ embr.201642698.

König T, Tröder SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, Mühlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli EI, De Stefani D, and Langer T: The m-AAA protease associated with neurodegeneration limits MCU activity in mitochondria. Mol Cell. (2016), 64: 148-62. doi: 10.1016/j.molcel.2016.08.020.

Hartmann B, Wai T, Hu H, MacVicar T, Musante L, Fischer-Zirnsak B, Stenzel W, Gräf R, van den Heuvel L, Ropers H-H, Wienker TF, Hübner C, Langer T, and Kaindl AM: Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation. eLife (2016), 5. doi: 10.7554/eLife.16078.

Aaltonen MJ, Friedman JR, Osman C, Salin B, di Rago J-P, Nunnari J, Langer T*, and Tatsuta T:* MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria. J Cell Biol. (2016), 213: 525-34. doi: 10.1083/jcb.201602007. *co-corresponding authors.

Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger H-G, Quiros .M, López-Otín C, Rugarli EI, and Langer T: Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. (2016), 212: 157-66. doi: 10.1083/jcb.201507022.

Wai T, García-Prieto J, Baker MJ, Merkwirth C, Benit P, Rustin P, Rupérez FJ, Barbas C, Ibañez B*, and Langer T:* Imbalanced OPA1 processing and mitochondrial fragmentation causes heart failure in mice. Science (2015), 350: 1221-33. doi: 10.1126/science.aad0116. *co-corresponding authors.

Moncunill-Massaguer C, Saura-Esteller J, Pérez-Perarnau A, Palmeri CM, Núñez-Vázquez S, Cosialls AM, González-Gironès DM, Pomares H, Korwitz A, Preciado S, Albericio F, Lavilla R, Pons G, Langer T, Iglesias-Serret D, and Gil J: A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget. (2015), 6: 41750-65. doi: 10.18632/oncotarget.6154.

Miliara X, Garnett JA, Tatsuta T, Abid Ali F, Baldie H, Pérez-Dorado I, Simpson P, Yague E, Langer T, and Matthews S: Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. EMBO Rep. (2015), 16: 824-35. doi: 10.15252/embr.201540229.

Mitsopoulos P, Chang Y-H, Wai T, König T, Dunn SD, Langer T, and Madrenas J: Stomatin-like protein 2 is required for in vivo mitochondrial respir¬atory chain supercomplex formation and optimal cell function. Mol Cell Biol. (2015), 35: 1838-47. doi: 10.1128/MCB.00047-15.

Kehrein K, Schilling R, Möller-Hergt BV, Wurm CA, Jakobs S, Lam¬ke¬meyer T, Langer T, and Ott M: Organization of mitochondrial gene expres¬sion in two distinct ribosome-containing assemblies. Cell Rep. (2015), 10: 843-853. doi: 10.1016/j.celrep.2015.01.012.
 
Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller R-U, Wiesner RJ, Langer T, Benzing T, and Brink-koetter PT: Inhibition of insulin/IGF-1 receptor signaling protects from mito¬chondria-mediated kidney failure. EMBO Mol Med. (2015), 7: 275-87. doi: 10.15252/emmm.201404916.

Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker MJ, Decker T, Lamkemeyer T, Rugarli EI, and Langer T: DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. Cell Metabol. (2014), 20: 158-71. doi: 10.1016/j.cmet. 2014.04.016.

Almontashiri NA, Chen H-H, Mailloux RJ, Tatsuta T, Teng AC, Mahmoud AB, Ho T, Stewart NA, Rippstein P, Harper ME, Roberts R, Willenborg C, and Erdmann J, for the CARDIoGRAM Consortium, Pastore A, McBride HM, Langer T, and Stewart AF: SPG7 variant excapes phosphorylation-regu¬lated processing by AFG3L2, elevates mitochondrial ROS, and is associated with mul¬tiple clinical phenotypes. Cell Rep. (2014), 7: 834-47. doi: 10.1016/j.celrep.2014.03.051.

Kondadi AK, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, Herholz D, Baker MJ, Schauss AC, Langer T, and Rugarli EI: Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyper¬phos¬phor¬ylation. EMBO J. (2014), 33: 1011-26. doi: 10.1002/embj.201387009.

Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, and Langer T: The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol. (2014), 204: 919-29. doi: 10.1083/ jcb.201308006.

Baker MJ, Lampe PA, Stojanovski D, Korwitz A, Anand R, Tatsuta T, and Langer T: Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics. EMBO J. (2014), 33: 578-93. doi 10.1002/embj. 201386474.
 
Bahat A, Perlberg S, Melamed-Book N, Lauria I, Langer T, and Orly J: StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation. Mol Endocrinol. (2014), 28: 208-24. doi: 10.1210/me.2013-1275.

Potting C, Tatsuta T, König T, Haag M, Wai T, Aaltonen MJ, and Langer T: TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid. Cell Metab. (2013), 18: 287-95. doi: 10.1016/j.cmet. 2013.07.008.

Supale S, Thorel F, Merkwirth C, Gjinovci A, Herrera PL, Scorrano L, Meda P, Langer T, and Maechler P: Loss of prohibitin induces mitochondrial dam¬ages altering ß-cell function and survival and is responsible for gradual diabetes devel¬op¬ment. Diabetes. (2013), 62: 3488-99. doi: 10.2337/db13-0152.
 
Anton F, Dittmar G, Langer T, and Escobar-Henriques M: Two deubi¬quit¬y¬l¬a¬ses act on mitofusin and regulate mitochondrial fusion along independent pathways. Mol Cell. (2013), 49: 487-98. doi: 10.1016/j.molcel. 2012.12.003.

Merkwirth C, Martinelli P, Korwitz A, Morbin M, Brönnecke HS, Jordan SD, Rugarli EI, and Langer T: Loss of prohibitin membrane scaffolds impairs mito¬chondrial architecture and leads to tau hyperphosphorylation and neurodegener¬a¬tion. PLoS Genet. (2012), 8: e1003021. doi: 10.1371/journal.pgen.1003021.

Klein JM, Busch JD, Potting C, Baker MJ, Langer T, and Schwarz G: The mitochondrial amidoxime-reducing component (mARC1) is a novel signal-anchored protein of the outer mitochondrial membrane. J Biol Chem. (2012), 287: 42795-803. doi: 10.1074/jbc.M112.419424.

Connerth M, Tatsuta T, Haag M, Klecker T, Westermann B, and Langer T: Intramitochondrial transport of phosphatidic acid in yeast by a lipid transfer pro¬tein. Science. (2012), 338: 815-18. doi: 10.1126/science.1225625.

Almajan ER, Richter R, Paeger L, Martinelli P, Barth E, Decker T, Larsson N-G, Kloppenburg P, Langer T, and Rugarli EI: AFG3L2 supports mitochon¬drial protein synthesis and Purkinje cell survival. J Clin Invest. (2012), 122: 4048-58. doi: 10.1172/JCI64604.

Pierson TM, Adams D, Bonn F, Martinelli P, Cherukuri PF, Teer JK, Hansen NF, Cruz P, Mullikin JC, for the NISC Comparative Sequencing Program, Blakesley RW, Golas G, Kwan J, Sandler A, Fuentes Fajardo K, Markello T, Tifft C, Blackstone C, Rugarli EI, Langer T, Gahl WA, and Toro C: Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases. PLoS Genet. (2011), 7: e1002325. doi: 10.1371/journal.pgen.1002325.

Alikhani N, Berglund A-K, Engmann T, Spånning E, Vögtle F-N, Pavlov P, Meisinger C, Langer T, and Glaser E: Targeting capacity and conservation of PreP homologues localization in mitochondria of different species. J Mol Biol. (2011), 410: 400-10. doi: 10.1016/j.jmb.2011.05.009.

Bonn F, Tatsuta T, Petrungaro C, Riemer J, and Langer T: Presequence-dependent folding ensures MRPL32 processing by the m-AAA protease in mitochon¬dria. EMBO J. (2011), 30: 2545-56. doi: 10.1038/emboj. 2011.169.
Anton F, Fres JM, Schauss A, Pinson B, Praefcke GJK, Langer T, and Esco¬bar-Henriques M: Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion. J Cell Sci. (2011), 124: 1126-35. doi: 10.1242/jcs.073080.

Anton F, Fres JM, Schauss A, Pinson B, Praefcke GJK, Langer T, and Esco¬bar-Henriques M: Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion. J Cell Sci. (2011), 124: 1126-35. doi: 10.1242/jcs.073080.

Lee S, Augustin S, Tatsuta T, Gerdes F, Langer T, and Tsai FT: Elec¬tron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease. J Biol Chem. (2011), 286: 4404-11. doi: 10.1074/jbc.M110.158741.
Potting C, Wilmes C, Engmann T, Osman C, and Langer T: Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35. EMBO J. (2010), 29: 2888-98. doi: 10.1038/emboj.2010.169.

Potting C, Wilmes C, Engmann T, Osman C, and Langer T: Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35. EMBO J. (2010), 29: 2888-98. doi: 10.1038/emboj.2010.169.

Osman C, Haag M, Wieland FT, Brügger B, and Langer T: A mitochon¬drial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. (2010), 29: 1976-87. doi: 10.1038/emboj.2010.98.

Di Bella D, Lazzaro F, Brusco A, Plumari M, Battaglia G, Pastore A, Finardi A, Cagnoli C, Tempia F, Frontali M, Veneziano L, Sacco T, Boda E, Brussino A, Bonn F, Castellotti B, Baratta S, Mariotti C, Gellera C, Fracasso V, Magri S, Langer T, Plevani P, Di Donato S, Muzi-Falconi M, and Taroni F: Muta¬tions in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nat Genet. (2010), 42: 313-21. doi: 10.1038/ng.544.

Bonn F, Pantakani K, Shoukier M, Langer T, and Mannan AU: Func¬tional evaluation of paraplegin mutations by a yeast complementation assay. Hum Mut. (2010), 31: 617-21. doi: 10.1002/humu.21226.

Ehses S, Raschke I, Mancuso G, Bernacchia A, Geimer S, Tondera D, Marti¬nou JC, Westermann B, Rugarli EI*, and Langer T:* Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J Cell Biol. (2009), 187: 1023-36. doi: 10.1083/jcb.200906084. *co-corresponding authors.

Augustin S, Gerdes F, Lee S, Tsai FT, Langer T*, and Tatsuta T: An intersub¬unit signaling network coordinates ATP hydrolysis by m-AAA proteases. Mol Cell. (2009), 35: 574-85. doi: 10.1016/j.molcel.2009.07.018. *corresponding author.

Koppen M, Bonn F, Ehses S, and Langer T: Autocatalytic processing of m-AAA protease subunits in mitochondria. Mol Biol Cell. (2009), 20: 4216-24. doi: 10.1091/mbc.E09-03-0218.

Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, Youle R, Langer T, and Martinou JC: SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J. (2009), 28: 1589-1600. doi: 10.1038/emboj.2009.89.

Osman C, Haag M, Potting C, Rodenfels J, Dip PV, Wieland FT, Brügger B, Westermann B, and Langer T: The genetic interactome of prohibitins: coordi¬nated control of cardiolipin and phosphatidylethanolamine by conserved regula¬tors in mitochondria. J Cell Biol. (2009), 184: 583-96. doi: 10.1083/jcb.200810189.

Merkwirth C, Dargazanli S, Tatsuta T, Geimer S, Löwer B, Wunderlich FT, von Kleist-Retzow J-C, Waisman A, Westermann B, and Langer T: Pro¬hibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morpho¬genesis in mitochondria. Genes Dev. (2008), 22: 476-88. doi: 10.1101/gad.460708.