Prof. Dr. rer. nat. Rudolf J Wiesner - Curriculum Vitae

Education and professional career

since 2013: Head of the Committee of the International Program for Health Sciences  (IPHS PhD program), Medical Faculty, University of Cologne
since 2007:
Head of the Habilitations Committee of the Medical Faculty, University of Cologne
since 1998: Full Professor (C3), Institute of Vegetative Physiology, Medical Faculty, University of Cologne
1994 - 1998: Dozent (lecturer) at the Institute of Physiology, University of Heidelberg
1993: Habilitation in Physiology, Faculty of Medicine, University of Heidelberg
1990 - 1994: Postdoctoral position at the Institute of Physiology, University of Heidelberg
1988 - 1990: DFG-Scholarship at the Department of Cardiology, University of Chicago
1986 - 1988: Postdoctoral position at Institute of Animal Physiology, University of Düsseldorf
1986: Promotion (Dr. rer. nat.) in Animal Physiology, Science Faculty, University of Düsseldorf
1976 - 1982: Studies in Biology (Diploma), University of Münster

Selected publications

Schommers P, Thurau A, Bultmann-Mellin I, Guschlbauer M, Klatt AR, Rozman J, Klingenspor M, Hrabe de Angelis M, Alber J, Gründemann D, Sterner-Kock A and Wiesner RJ (2017): Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state. Mol Metab 6, 737-747.

Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GKH, Repp B, Aichler M, Feuchtinger A., Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Prokisch H, Beckers J, Walch AK, Fuchs H, Wolf E, Schubert M, Wiesner RJ and Hrabe de Angelis M (2016): Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ treated diabetic mice. Diabetes 65, 2540-2552.

Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do H.-T, Wibom R, Wiesner RJ, Krüger M and Trifunovic A. CLPP coordinates mitoribosomal assembly through regulation of ERAL1 levels. EMBO J 2016, 35, 2566-2583.

Baris OR, Ederer S, Neuhaus JFG, von Kleist-Retzow JC, Wunderlich CM, Pal M, Wunderlich FT, Peeva V, Zsurka G, Kunz WS, Hickethier T, Bunck AC, Stöckigt F, Schrickel JW and Wiesner RJ. Mosaic deficiency in mitochondrial oxidative metabolism promotes cardiac arrhythmia during aging. Cell Metabolism 2015, 21, 667-77.

Kloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Tobin DJ, Niemann C, Wiesner RJ* and Paus R. Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions. J Invest Dermatol 2015, 135, 679-89. *corresponding author.

Franko A, von Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stöhr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, Hrabe de Angelis M, Paulsson M, Schubert M and Wiesner RJ. Liver adapts mitochondrial function to insulin resistant and diabetic states in mice. J Hepatol 2014, 60, 816-823.

Neuhaus JFG, Baris OR, Hess S, Moser N, Schröder HJ, Chinta SJ, Andersen JK, Kloppenburg P and Wiesner RJ. Catecholamine metabolism drives the generation of mitochondrial DNA deletions in dopaminergic neurons. Brain 2014, 137:354-65.

Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Hagström E, Chatzidaki-Trinks E, Wiesner RJ, Samuels DC, Larsson NG and Chinnery PF. Variation in germ-line mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet 2012, 44, 1282-1285.

Franko A, von Kleist-Retzow JC, Böse M, Sanchez-Lasheras C, Brodesser S, Krut O, Kunz WS, Wiedermann D, Hoehn M, Stöhr O, Moll L, Freude S, Krone W, Schubert M and Wiesner RJ. Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance impairs respiratory chain function in muscle. J Mol Med 2012, 0, 1145-1160.

Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kolberg G, Rötig A, Hellmich M, Nijtmans L and Wiesner RJ. Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly. EMBO J 2012, 31,1293-307.

Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JFG, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T, Tobin DJ, Paus R and Wiesner RJ. The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells 2011, 29, 1459-1468.