Dr. med. Igor Jakovcevski - Curriculum Vitae

Education and professional career

since 2014: Senior scientist at Experimental Neurophysiology, DZNE Bonn/University Hospital of Cologne
2008 - 2009: Visiting scientist at the Department of Neuroscience (Prof. Nada Zecevic), University of Connecticut Health Center
2007 - 2013: Research group leader at the Institute for Biosynthesis of Neural Structures (Prof. Melitta Schachner) of the Center for Molecular Neurobiology Hamburg
2005 - 2007: Postdoctoral fellow at the Institute for Biosynthesis of Neural Structures (Prof. Melitta Schachner) of the Center for Molecular Neurobiology Hamburg
2002 - 2005: Postdoctoral fellow at the Department of Neuroscience (Prof. Nada Zecevic), University of Connecticut Health Center
1999 - 2001: Assistant Professor at the Department of Microbiology and Immunology, University of Banja Luka School of Medicine (Bosnia and Herzegovina)
1996 – 1998: Resident physician at the Department of Cardiology, Clinical Hospital Zemun of the University Medical Center Belgrade (Serbia)
1989 - 1996: Studies of human medicine, University of Belgrade, M.D.

Awards, distinctions and professional activities

since 2017: Center for Molecular Medicine Cologne Research Prize, Co-PI
2015 - 2016: Deutsche Akademische Austauschdienst (DAAD), Program for Personal Exchange with Serbia, PI
2012 - 2014: COST action BM1001, member
since 2011: Serbian society for neuroscience, member
since 2003: Society for neuroscience (SFN), member

Selected publications

* shared authorship
Ortega JA, Memi F, Radonjic N, Filipovic R, Bagasrawala I, Zecevic N, and Jakovcevski I: The subventricular zone: a key player in human neocortical development. Neuroscientist. 2017, DOI: 10.1177/1073858417691009.

Saini V, Loers G, Kaur G, Schachner M, and Jakovcevski I: Impact of neural cell adhesion molecule deletion on regeneration after mouse spinal cord injury. Eur J Neurosci. 2016, 44: 1734-46.

Marguet SL, Le-Schulte VT, Merseburg A, Neu A, Eichler R, Jakovcevski I, Ivanov A, Hanganu-Opatz IL, Bernard C, Morellini F, and Isbrandt D: Treatment during a vulnerable developmental period rescues a genetic epilepsy. Nat Med. 2015, 21: 1436-44.

Schmalbach B, Lepsveridze E, Djogo N, Papashvili G, Kuang F, Leshchyns'ka I, Sytnyk V, Nikonenko AG, Dityatev A, Jakovcevski I*, and Schachner M*: Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene. J Neurochem. 2015, 135: 830-44.

Rost S, Akyüz N, Martinovic T, Huckhagel T, Jakovcevski I*, and Schachner M*: Germline ablation of dermatan-4O-sulfotransferase1 reduces regeneration after mouse spinal cord injury. Neuroscience. 2016, 312: 74-85.

Lutz D, Kataria H, Kleene R, Loers G, Chaudhary H, Guseva D, Wu B, Jakovcevski I, and Schachner M: Myelin Basic Protein Cleaves Cell Adhesion Molecule L1 and Improves Regeneration After Injury. Mol Neurobiol. 2016, 53: 3360-76.

Papastefanaki F, Jakovcevski I, Poulia N, Djogo N, Schulz F, Martinovic T, Ciric D, Loers G, Vossmeyer T, Weller H, Schachner M, and Matsas R: Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury. Mol Ther. 2015, 23: 993-1002.

Radonjic NV, Ayoub AE, Memi F, Yu X, Maroof A, Jakovcevski I, Anderson SA, Rakic P, and Zecevic N: Diversity of cortical interneurons in primates: the role of the dorsal proliferative niche. Cell Rep. 2014, 9: 2139-51.

Katic J, Loers G, Kleene R, Karl N, Schmidt C, Buck F, Zmijewski JW, Jakovcevski I, Preissner KT, and Schachner M: Interaction of the cell adhesion molecule CHL1 with vitronectin, integrins, and the plasminogen activator inhibitor-2 promotes CHL1-induced neurite outgrowth and neuronal migration. J Neurosci. 2014, 34: 14606-23.

Mehanna A, Szpotowicz E, Schachner M, and Jakovcevski I: Improved regeneration after femoral nerve injury in mice lacking functional T- and B-lymphocytes. Exp Neurol. 2014, 261: 147-55.

Xu JC, Xiao MF, Jakovcevski I, Sivukhina E, Hargus G, Cui YF, Irintchev A, Schachner M, and Bernreuther C: The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice. J Cell Sci. 2014, 127: 641-52.

Jakovcevski I, Djogo N, Hölters LS, Szpotowicz E, and Schachner M: Transgenic overexpression of the cell adhesion molecule L1 in neurons facilitates recovery after mouse spinal cord injury. Neuroscience. 2013, 252: 1-12.

Jakovcevski M, Bharadwaj R, Straubhaar J, Gao G, Gavin DP, Jakovcevski I, Mitchell AC, and Akbarian S: Prefrontal cortical dysfunction after overexpression of histone deacetylase 1. Biol Psychiatry. 2013, 74: 696-705.

Djogo N*, Jakovcevski I*, Müller C, Lee HJ, Xu JC, Jakovcevski M, Kügler S, Loers G, and Schachner M: Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in mice. Neurobiol Dis. 2013, 56: 104-15.

Jakovcevski I, Miljkovic D, Schachner M, and Andjus PR: Tenascins and inflammation in disorders of the nervous system. Amino Acids. 2013, 44: 1115-27.

Wu B, Matic D, Djogo N, Szpotowicz E, Schachner M, and Jakovcevski I: Improved regeneration after spinal cord injury in mice lacking functional T- and B-lymphocytes. Exp Neurol. 2012, 237: 274-85.

Reinchisi G, Ijichi K, Glidden N, Jakovcevski I, and Zecevic N: COUP-TFII expressing interneurons in human fetal forebrain. Cereb Cortex. 2012, 22: 2820-30.

Bian S, Akyüz N, Bernreuther C, Loers G, Laczynska E, Jakovcevski I, and Schachner M: Dermatan sulfotransferase Chst14/D4st1, but not chondroitin sulfotransferase Chst11/C4st1, regulates proliferation and neurogenesis of neural progenitor cells. J Cell Sci. 2011, 124: 4051-63.

Moore AR, Zhou WL, Jakovcevski I, Zecevic N, and Antic SD: Spontaneous electrical activity in the human fetal cortex in vitro. J Neurosci. 2011, 31: 2391-8.

Zecevic N, Hu F, and Jakovcevski I: Interneurons in the developing human neocortex. Dev Neurobiol. 2011, 71: 18-33.

Jakovcevski I, Mayer N, and Zecevic N: Multiple origins of human neocortical interneurons are supported by distinct expression of transcription factors. Cereb Cortex. 2011, 21: 1771-82.

Devanathan V, Jakovcevski I, Santuccione A, Li S, Lee HJ, Peles E, Leshchyns'ka I, Sytnyk V, and Schachner M: Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth. J Neurosci. 2010, 30: 9292-305.

Chen J, Joon Lee H, Jakovcevski I, Shah R, Bhagat N, Loers G, Liu HY, Meiners S, Taschenberger G, Kügler S, Irintchev A, and Schachner M: The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration. Mol Ther. 2010, 18: 1769-77.

Morellini F, Sivukhina E, Stoenica L, Oulianova E, Bukalo O, Jakovcevski I, Dityatev A, Irintchev A, and Schachner M: Improved reversal learning and working memory and enhanced reactivity to novelty in mice with enhanced GABAergic innervation in the dentate gyrus. Cereb Cortex. 2010, 20: 2712-27.

Mehanna A, Jakovcevski I, Acar A, Xiao M, Loers G, Rougon G, Irintchev A, and Schachner M: Polysialic acid glycomimetic promotes functional recovery and plasticity after spinal cord injury in mice. Mol Ther. 2010, 18: 34-43.

Jakovcevski I, Filipovic R, Mo Z, Rakic S, and Zecevic N: Oligodendrocyte development and the onset of myelination in the human fetal brain. Front Neuroanat. 2009, 3: 5.

Lieberoth A, Splittstoesser F, Katagihallimath N, Jakovcevski I, Loers G, Ranscht B, Karagogeos D, Schachner M, and Kleene R: Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth. J Neurosci. 2009, 29: 6677-90.

Jakovcevski I, Siering J, Hargus G, Karl N, Hoelters L, Djogo N, Yin S, Zecevic N, Schachner M, and Irintchev A: Close homologue of adhesion molecule L1 promotes survival of Purkinje and granule cells and granule cell migration during murine cerebellar development. J Comp Neurol. 2009, 513: 496-510.

Jakovcevski I, Mo Z, and Zecevic N: Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain. Neuroscience. 2007, 149: 328-37.

Jakovcevski I, Wu J, Karl N, Leshchyns'ka I, Sytnyk V, Chen J, Irintchev A, and Schachner M: Glial scar expression of CHL1, the close homolog of the adhesion molecule L1, limits recovery after spinal cord injury. J Neurosci. 2007, 27: 7222-33.