Prof. Dr. med. Dirk Isbrandt - Curriculum Vitae

Education and professional career

since 2015: Director of the Institute for Molecular and Behavioral Neuroscience, University of Cologne
since 2013:
Professor for Experimental Neurophysiology, DZNE-Bonn/University of Cologne
2009 - 2013: Head of the DFG-Heisenberg Team Experimental Neuropediatrics at the Center for Obstetrics and Pediatrics and the Center for Molecular Neurobiology Hamburg
2005 - 2006: Visiting scientist, Center for Molecular and Behavioral Neuroscience, Rutgers University, Prof. G. Buzsáki, Newark, NJ, USA
1998 - 2008: Research group leader, Institute for Neural Signal Transduction, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Germany
1996 - 1997: Research group leader, Children’s Hospital of the University Hospital Hamburg-Eppendorf
1996 – 1997: Resident, Children’s Hospital of the University Medical Center Hamburg-Eppendorf

Awards, distinctions and professional activities

2008: Award of a DFG-Heisenberg Professorship
2007: Award of a ‘Directeur de Recherche’ (DR2, equivalent to associate professor) position by INSERM (Paris, France)
2007: Award of a grant within the international ‘AVENIR’ program by INSERM (Paris, France)
2005: Human Frontier Science Project (HFSP); Short-Term Fellowship
2001: Bruno-Kisch Research Prize 2001 of the German Cardiological Society

Selected publications

Fazeli W, Zappettini S, Marguet SL, Grendel J, Esclapez M, Bernard C, Isbrandt D. Early-life exposure to caffeine affects the construction and activity of cortical networks in mice. Exp Neurol. 2017 May 30;295:88-103.

Marguet SL, Le-Schulte VTQ, Merseburg A, Neu A, Eichler R, Jakovcevski I, Ivanov A, Hanganu-Opatz I L, Bernard C, Morellini F & Isbrandt D. Treatment during a vulnerable developmental period rescues a genetic epilepsy. Nat. Med. 2015; 21(12): 1436-1444.

Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME. Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation. Nat Commun. 2014;5:4664.

Choe CU, Atzler D, Wild PS, Carter AM, Böger RH, Ojeda F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, Lüneburg N, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E. Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies. Circulation 2013;128(13):1451-61.
 
Choe CU, Nabuurs C, Stockebrand MC, Neu A, Nunes P, Morellini F, Sauter K, Schillemeit S, Hermans-Borgmeyer I, Marescau B, Heerschap A, Isbrandt D.    L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome. Hum Mol Genet. 2013;22(1):110-23.

Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.    Control of heart rate by cAMP sensitivity of HCN channels. Proc Natl Acad Sci U S A. 2009;106(29):12189-94.
 
Choe C, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori SG, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D. (C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Hum Mol Genet. 2006, 15:2888–2902.

Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D. Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci. 2005 8(1):51-60.

Schmidt A, Marescau B, Boehm EA, Renema WKJ, Peco R, Das A, Steinfeld R, Chan S, Wallis J, Davidoff M, Ullrich K, Waldschütz R, Heerschap A, de Deyn PP, Neubauer S, Isbrandt D. Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency. Hum Mol Genet. 2004, 13:905–921

Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest. 2003, 111:1537–1545.