Dr. rer. nat. Alvaro Rada-Iglesias - Curriculum Vitae

Education and professional career

since 2013: Junior Group Leader, Center for Molecular Medicine Cologne (CMMC), University of Cologne (Germany).
2009 - 2013: Postdoctoral  fellow at Joanna Wysocka’s lab, Department of Chemical and Systems Biology, Stanford University (USA).
2008 - 2009: Researcher at Jan Komorowski´s lab, Linnaeus Centre for Bioinformatics, Uppsala University (Sweden).
2002 - 2007: PhD student, Rudbeck Laboratory, Uppsala University, Sweden
1997-2001: M.Sc. in Biology. Leon University (Spain)

Awards, distinctions and professional activities

since 2013: Reviewer for the following international journals: Cell, Cell Stem Cell, Molecular Cell, Nature Genetics, Trends in Molecular Medicine, PNAS, PlOS Genetics, PlOS One, Genome Research, Cell Death and Differentiation, Journal of Cell Biology
2017: Evaluation committee of “Ramon y Cajal” funding programme, Spain.
2017: Scientific reviewer for the “ERC Starting Grants” funding programme.
2016: Scientific reviewer for the Wellcome Trust (UK)
2016: Scientific reviewer for the United States-Israel Binational Science Foundation (BSF)
2016: Evaluation committee of “Juan de la Cierva” funding programme
since 2015: Scientific advisor of the French National Research Agency’s (ANR)
since 2015: Scientific advisor of the Spanish National Evaluation and Foresight Agency   (ANEP), Spanish ministry of Econcomy and Competitiveness
2012: Siebel Scholar award
2011: Forbeck Research Foundation Scholar award
2009: EMBO long-term fellowship
2001: University of Leon award as best academic curriculum at Faculty of Biological Science

Selected publications

Cruz-Molina S, Respuela P, Tebartz C, Kolovos P, Nikolic M, Fueyo R, van Ijcken W.F.J, Grosveld F, Frommolt P, Bazzi H, Rada-Iglesias A#. PRC2 facilitates the regulatory topology required for poised enhancer function during pluripotent stem cell differentiation. Cell Stem Cell. 2017.02.004 [Epub ahead of print].

Ludwig KU, Böhmer AC, Bowes J, Nikolic M, Ishorst N, Wyatt N, Hammond NL, Gölz L, Thieme F, Barth S, Schuenke H, Klamt J, Spielmann M, Aldhorae K, Rojas-Martinez A, Nöthen MM, Rada-Iglesias A, Dixon MJ, Knapp M, Mangold E. Imputation of Orofacial Clefting Data Identifies Novel Risk Loci and Sheds Light on the Genetic Background of Cleft Lip ± Cleft Palate and Cleft Palate Only. Hum Mol Genet. 2017 Jan 13. pii: ddx012. doi: 10.1093/hmg/ddx012. [Epub ahead of print].

Nikolic M, Papantonis A, Rada-Iglesias A#. GARLIC: A Bioinformatic Toolkit for Etiologically Connecting Diseases and Cell Type-Specific Regulatory Maps. Hum Mol Genet. 2016 Dec 22. pii: ddw423. doi: 10.1093/hmg/ddw423. [Epub ahead of print].

Rehimi R, Nikolic M, Cruz-Molina S, Tebartz C, Frommolt P, Mahabir E, Clément-Ziza M, Rada-Iglesias A#. Epigenomics-Based Identification of Major Cell Identity Regulators within Heterogeneous Cell Populations. Cell Rep. 2016 Dec 13;17(11):3062-3076.

Respuela P and Rada-Iglesias A#. Enhancer Remodeling During Early Mammalian Embryogenesis:Lessons for Somatic Reprogramming, Rejuvenation, and Aging. Curr Stem Cell Rep. 2016 May 2:263–272
Respuela P, Nikolic P, Tan M, Frommolt P, Zhao Y, Wysocka J and Rada-Iglesias A#. Foxd3 promotes exit from naïve pluripotency through enhancer decommissioning and inhibits germline specification. Cell Stem Cell. 2016 Jan 7;18(1):118-133. PMID:26748758.

Rada-Iglesias A#. Genetic variation within transcriptional regulatory elements and its implications for human disease. Biol Chem. 2014 Dec 1;395(12):1453-60. PMID:25205712.

Rada-Iglesias A, Prescott SL, and Wysocka, J. Human genetic variation within    neural crest enhancers: molecular and phenotypic implications. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2013 May 368, 20120360. PMID:23650634.

Rada-Iglesias A#. Pioneering barren land: mitotic bookmarking by transcription factors. Dev Cell. 2013 Feb 25;24(4):342-4. PMID:2344970.

Rada-Iglesias A*, Bajpai R*, Prescott R, Brugmann S, Swigut T and Wysocka J. Epigenomic mapping annotates human neural crest enhancers and predicts a new role for nuclear receptors NR2F1/2. Cell Stem Cell 2012 Nov 2;11(5):633-48. PMID: 22981823.

Valdés AE, Overnäs E, Johansson H, Rada-Iglesias A, Engström P. The homeodomain-leucine zipper (HD-Zip) class I transcription factors ATHB7 and ATHB12 modulate abscisic acid signalling by regulating protein phosphatase 2C and abscisic acid receptor gene activities. Plant Mol Biol. 2012 Nov;80(4-5):405-18. doi: 10.1007/s11103-012-9956-4.

Enroth S, Rada-Iglesias A, Andersson R, Wallerman O, Wanders A, Påhlman L, Komorowski J, Wadelius C. Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa. BMC Cancer. 2011 Oct 19; 11:450. PMID:22011431.

Rada-Iglesias A, Wysocka J. Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease. Genome Med. 2011 Jun 7;3(6):36. PMID:21658297.

Ma Z, Swigut T, Valouev A, Rada-Iglesias A, Wysocka J . Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates. Nat Struct Mol Biol. 2011 Feb;18(2):120-7. PMID:21183938.

Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J. A unique chromatin signature uncovers early developmental enhancers in humans. Nature. 2011 Feb 10;470(7333):279-83. PMID:21160473.

Sandgren J, Andersson R, Rada-Iglesias A, Enroth S, Akerstrom G, Dumanski JP, Komorowski J, Westin G, Wadelius C Integrative epigenomic and genomic analysis of malignant pheochromocytoma.. Exp Mol Med. 2010 Jul 31;42(7):484-502. PMID:20534969.

Bajpai R, Chen DA, Rada-Iglesias A, Zhang J, Xiong Y, Helms J, Chang CP, Zhao Y, Swigut T, Wysocka J. CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature. 2010 Feb 18;463(7283):958-62. PMID:20130577.

Andersson R*, Enroth S*, Rada-Iglesias A*, Wadelius C, Komorowski J.. Nucleosomes are well positioned in exons and carry characteristic histone modifications.. Genome Res. 2009 Oct;19(10):1732-41. PMID:19687145.

Motallebipour M, Rada-Iglesias A, Westin G, Wadelius C. Two polypyrimidine tracts in the nitric oxide synthase 2 gene: similar regulatory sequences with different properties.. Mol Biol Rep. 2010 Apr;37(4):2021-30. PMID:19669598.

Ameur A*, Rada-Iglesias A*, Komorowski J, Wadelius C. Identification of candidate regulatory SNPs by combination of transcription-factor-binding site prediction, SNP genotyping and haploChIP. Nucleic Acids Res. 2009 Jul;37(12):e85. PMID:19451166.

Rada-Iglesias A, Enroth S, Andersson R, Wanders A, Påhlman L, Komorowski J, Wadelius C. Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation.. Epigenetics. 2009 Feb 16;4(2):107-13. PMID:19276669.

Patricia Respuela, Marcela Ferella, Alvaro Rada-Iglesias and Lena Åslund, Histone acetylation at bidirectional promoters of divergent polycistronic gene clusters in Trypanosoma cruzi. J Biol Chem, 2008 Jun 6;283(23):15884-92. PMID:18400752.

Alvaro Rada-Iglesias*, Adam Ameur*, Philipp Kapranov, Stefan Enroth, Jan Komorowski, Thomas R. Gingeras, Claes Wadelius. Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders. Genome Research, 2008 Mar;18(3):380-92. PMID:18230803.

Michael  Draminski, Alvaro Rada-Iglesias, Stefan Enroth, Claes Wadelius, Jacek Koronacki, Jan Komorowski, Monte Carlo feature selection for supervised classification. Bioinformatics, 2008 Jan 1;24(1):110-7. PMID:18048398.

Rada-Iglesias A, Enroth S, Ameur A, Koch CM, Clelland GK, Respuela-Alonso P, Wilcox S, Dovey OM, Ellis PD, Langford CF, Dunham I, Komorowski J, Wadelius C. Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes. Genome Research, 2007 Jun;17(6):708-19. PMID:17567991.

The ENCODE project consortium, Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, 2007 Jun 14;447(7146):799-816. PMID:17571346.

Sigrun M. Gustafsdottir, Alvaro Rada-Iglesias, Joerg Schlingemann, Masood Kamali- Moghaddam, Claes Wadelius & Ulf Landegren, Global analysis of transcription factor interactions with their cognate elements via proximity ligation. Proc Natl Acad Sci U S A, 2007 Feb 27;104(9):3067-72. PMID:17360610.

These authors equally contributed to the work.
# Corresponding Author