Prof. Dr. rer. nat. Hamid Kashkar - Curriculum Vitae

Education and professional career

since 2015: Professor for Immunology
since 2014: Independent research group leader CECAD cluster of Excellence and IMMIH, University of Cologne
2011 - 2013: Independent research group leader “Career Development Award”, Center for Molecular Medicine, Cologne (CMMC), University of Cologne
2005 - 2010: Independent research group leader, Institute for Med. Microbiology, Immunology and Hygiene (IMMIH), University of Cologne
2015: adjunct professorship    (APL Professur)
2008: postdoctoral lecture qualification (“Habilitation”) in immunology, University of Cologne
2002:
PhD, University of Cologne
2000:
Dipl. Biology, University of Cologne

Selected publications

Kashkar H, Deggerich A, Seeger JM, Yazdanpanah B, Wiegmann K, Haubert D, Pongratz C, Krönke M: NF-?B independent down-regulation of XIAP by bortezomib sensitizes HL B-cells against cytotoxic drugs. Blood, 2007, 109:3982-88.

Haubert D, Gharib N, Rivero F, Wiegmann K, Hösel M, Krönke M, Kashkar H: PtdIns(4,5)P-restricted plasma membrane localization of FAN is involved in TNF-induced actin reorganization. EMBO J., 2007, 26:3308–3321.

Herz J, Pardo J, Kashkar H, Schramm M, Kuzmenkina E, Bos E, Wiegmann K, Wallich R, Peters PJ, Herzig S, Schmelzer E, Krönke M, Simon MM, and Utermöhlen O: Acid sphingomyelinase is a critical regulator of cytotoxic granule secretion by primary T Lymphocytes Nat. Immunol. 2009, 10:761-8.

Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M: Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature 2009, 460:1159-63.
    
Mertens J, Fabri M, Zingarelli A, Kubacki T, Meemboor S, Groneck L, Seeger JM, Bessler M, Hafke H, Odenthal M, Bieler JG, Kalka C, Schneck JP, Kashkar H, Kalka-Moll WM: Streptococcus pneumoniae serotype 1 capsular polysaccharide induces CD8+CD28- regulatory T lymphocytes by TCR crosslinking. PLoS pathogens 2009, 5:e1000596.

Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann J, Koker M, Heynck S, Stückrath I, Weiß J, Fischer F, Goel A, Regales L, Perera S, Getlik M, Heukamp L, Ansén S, Zander T, Beroukhim R, Kashkar H, Shokat K, Sellers WR, Meyerson M, Rauh D, Hoeflich K, Orr C, Friedman L, Wong KK, Pao W, Thomas RK: Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.  Proc Natl Acad Sci U S A 2009, 106:18351-6.

Seeger JM, Schmidt P, Brinkmann K, Hombach A, Coutelle O, Zigrino P, Wagner-Stippich D, Mauch C, Abken H, Krönke M, and Kashkar H: The proteasome inhibitor Bortezomib sensitizes melanoma cells towards adoptive CTL attack. Cancer Res. 2010, 70:1825-34.

Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkonen VM, Braun T, Böttger T, Seibler J, Brüning JC: Obesity-Induced Overexpression of miRNA-143 Inhibits Insulin-Stimulated AKT Activation and Impairs Glucose Metabolism. Nat. Cell Biol. 2011, 13(4), 434-446.

Wohlleber D*, Kashkar H*, Gärtner K*, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Niesswandt B, van Rooijen N, Limmer A, Cederbrand K, Heikenwälder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA: TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation. Cell Rep. 2012, 2(3):478-487 *equal contribution.
    
Brinkmann K, Zigrino P, Witt A, Schell M, Ackermann L, Broxtermann PN, Schüll S, Andree M, Coutelle O, Yazdanpanah B, Seeger JM, Klubertz D, Drebber U, Hacker UT, Krönke M, Mauch C, Hoppe T, Kashkar H: Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA. Cell Rep. 2013, 3(3):881-91.

Gruber S, Straub B, Ackermann JP, Wunderlich CM, Mauer J, Seeger JM, Büning H, Heukamp L, Kashkar H, Schirmacher P, Brüning JC, WunderlichFT: Obesity Promotes Liver Carcinogenesis via Mcl-1 Stabilization Independent of IL-6Ra Signaling. Cell Rep. 2013, 4(4):669-680.

Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Liwschitz M, Seeger JM, Piekarek M, Brinkmann K, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H: Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing EMBO Mol. Med. 2014, 6:624-639.

Bielig H, Lautz K, Braun PR, Menning M, Machuy N, Brügmann C, Barisic S, Eisler SA, Andree M, Kashkar H, Zurek B, Hausser A, Sansonetti PJ, Meyer TF, Kufer TA: The cofilin phosphatase Slingshot Homolog 1 (SSH1) links NOD1 signalling to actin remodeling. PLoS pathogens 2014, 10:e1004351.

Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich C, Brinkmann K, Broxtermann PN, Witt A., Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Koch A, Wunderlich, FT, Villunger A, Martins LM, Krönke M, Kufer T, Utermöhlen O, Kashkar H: BID-mediated release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. EMBO J. 2014, 33:2171-2187.

Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel LP: Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Leukemia 2015, 29:981-4.

Witt A, Seeger JM, Coutelle O, Zigrino P, Broxtermann P, Andree M, Brinkmann K, Jüngst C, Schauss AC, Schüll S, Wohlleber D, Knolle P, Krönke M, Mauch C, Kashkar H: IAP antagonization induces inflammatory destruction of vascular endothelium EMBO Rep. 2015, 16:719-727.

Förster A, Grotha S, Seeger JM, Rabenhorst A, Gehring M, Raap U, Létard S, Dubreuil P, Kashkar H, Walczak H, Roers A, Hartmann K: Activation of KIT modulates the function of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) in mast cells. Allergy 2015, 70:764-74.

Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Kashkar H, Ramadan K, Hoppe T: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat. Commun. 2016, 7:10612.

Knittel G*, Liedgens P*, Korovkina D*, Seeger JM*, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L, Consortium IM, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP§, Kashkar H§, Reinhardt HC§: B cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B cell lymphoma in mice. Blood 2016, 127(22):2732-41. * and § equal contribution.

Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krueger M, Langer M: PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis. Nat. Cell Biol. 2017, 19:318–328.