Prof. Dr. med. Florian Klein - Curriculum Vitae

Education and professional career

since 2015: W3-Heisenberg Professor, University of Cologne
2013 - 2015: Assistant Professor of Clinical Investigation, The Rockefeller University
2013: Master of Science, Translational Medicine, The Rockefeller University
2012 - 2013: Chief Clinical Scholar, The Rockefeller University Hospital
2009 - 2011: Postdoctoral Associate, The Rockefeller University
2009: Doctoral thesis (summa cum laude), Institute of Microbiology, Immunology and Hygiene, University of Cologne
2006 - 2009: Resident, Department of Internal Medicine I, University of Cologne
1998 - 2005: Medical School (University of Cologne, University of Zurich, Università di Bologna, Harvard Medical School)

Awards, distinctions and professional activities

2015: German AIDS Award 2015
2014: Heisenberg Fellowship, German Research Foundation, DFG
2014: ERC Starting Grant, European Research Council
2013: AIDS Research Award, German Society of Infectious Diseases
2009: Research Fellowship, German Research Foundation, DFG
2009: Best Doctoral Thesis Award, University of Cologne
2002 - 2005: Scholarship of the Studienstiftung des deutschen Volkes
2005: Scholarship of the Sokrates / Erasmus program
2004: Travel Award, American Society of Hematology
2001 - 2004:  Köln Fortune Award, University of Cologne

Selected publications

Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP Jr, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, Lehmann C, Burke LA, Hawthorne T, Gorelick RJ, Walker BD, Keler T, Gulick RM, Fätkenheuer G,
Schlesinger SJ, Nussenzweig MC. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature. 2015, Apr 8.

Klein F, Nogueira L, Nishimura Y, Phad G, West AP Jr, Halper-Stromberg A, Horwitz JA, Gazumyan A, Liu C, Eisenreich TR, Lehmann C, Fätkenheuer G, Williams C, Shingai M, Martin MA, Bjorkman PJ, Seaman MS, Zolla-Pazner S, Karlsson Hedestam GB, Nussenzweig MC. Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J Exp Med. 2014, Nov 17.

Bournazos S, Klein F, Pietzsch J, Seaman MS, Nussenzweig MC, Ravetch JV. Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. Cell. 2014, Sep 11; 158(6):1243-53.

Gruell H, Klein F. Opening Fronts in HIV Vaccine Development: Tracking the development of broadly neutralizing antibodies. Nat Med. 2014, May 7.

Shingai M, Nishimura Y, Klein F, Mouquet H, Donau OK, Plishka R, Buckler-White A, Piatak M, Lifson JD, Dimitrov D, Nussenzweig MC and Martin MA. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature. 2013, Nov 14;503(7475):277-80.

Klein F, Mouquet H, Dosenovic P, Scheid JF, Scharf L, Nussenzweig MC. Antibodies in HIV-1 Vaccine Development and Therapy. Science. 2013, Sep 13.

Klein F, Diskin R, Scheid JF, Gaebler C, Mouquet H, Georgiev IS, Pancera M, Zhou T, Incesu RB, Fu BZ, Gnanapragasam PN, Oliveira TY, Seaman MS, Kwong PD, Bjorkman PJ, Nussenzweig MC. Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralizing activity. Cell. 2013, Mar 28.

Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A, Zang T, Dorner M, Billerbeck E, Labitt RN, Gaebler C, Marcovecchio PM, Incesu RB, Eisenreich TR, Bieniasz PD, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature. 2012, Dec 6.

Klein F, Gaebler C, Mouquet H, Sather N, Lehmann C, Scheid JF, Kraft Z, Liu Y, Pietzsch J, Hurley A, Feizi T, Morris L, Walker BD, Fätkenheuer G, Seaman MS, Stamatatos L, Nussenzweig MC. Broad neutralization by a combination of antibodies to the CD4 binding site and a new conformational
epitope on the HIV envelope protein. J Exp Med. 2012, Jul 30; 209(8):1469-79.

Klein F, Feldhahn N, Harder S, Wang H, Wartenberg M, Siebert R, Hofmann WK, Wernet P, Müschen M. The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells. J Exp Med. 2004, Mar 1; 199(5):673-85.

Klein F, Feldhahn N, Lee S, Wang H, Ciuffi F, von Elstermann M, Toribio ML, Sauer H, Wartenberg M, Barath VS, Krönke M, Wernet P, Rowley JD, Müschen M. T lymphoid differentiation in human bone marrow. Proc Natl Acad Sci USA. 2003, May 27;100(11):6747-52.