Deniz Hos - CAP 11

The contribution of myeloid cells to corneal neovascular disease

Abstract

The cornea, which the transparent front part of the eye, is physiologically avascular and alymphatic. However, severe inflammation can lead to a secondary ingrowth of pathologic blood and lymphatic vessels into the cornea, resulting in loss of its transparency and reduced visual acuity. Furthermore, corneal blood and lymphatic vessels play a crucial role in the pathogenesis of corneal transplant rejection, dry eye disease, and ocular allergy. In fact, loss of corneal transparency due to severe inflammation and neovascularization is one of the leading causes of blindness worldwide. Deciphering the cellular players and molecular mechanisms of inflammatory corneal neovascularization is therefore of uttermost importance. Substantial preclinical evidence indicates that myeloid cells are important mediators of inflammatory corneal neovascularization. However, the specific mechanisms and mediators how myeloid cells contribute to corneal hem- and lymphangiogenesis are not fully resolved and require more detailed analysis. Therefore, the aim of this project is to investigate the specific role of various myeloid cell subsets, in particular macrophages and neutrophilic granulocytes, in acute and chronic corneal tissue damage. Translationally, these findings may provide novel therapeutic strategies to limit pathological corneal neovascularization by modulating local immune responses.

Clinical/medical relevance and sustainability in disease understanding

Loss of corneal transparency due to severe inflammation and neovascularization is one of the leading causes of blindness worldwide. This project aims to investigate the functional relationship between myeloid cells, in particular macrophages and neutrophilic granulocytes, and corneal neovascularization in various preclinical neovascular disease models. Our findings might contribute to future immunomodulatory therapeutic strategies to promote corneal repair and/or prevent disease


Dr. Dr. Deniz Hos

Dept. of Ophthalmology

Dr. Dr. Deniz Hos

Co-Principal Investigator B 3 / Principal Investigator CAP 11

deniz.hos@uk-koeln.de

Work +49 221 478 98896

Building 13
Kerpener Str. 62
50924 Cologne

Publications - Deniz Hos

Link to PubMed