Björn Schumacher / Ashley Williams - B 5

Chronic inflammatory responses to persistent cytoplasmic DNA

Abstract

Chronic inflammation causes tissue damage and degeneration, thus contributing to aging-associated declines in the functional integrity of tissues and organs. Inflammatory responses to DNA cause polyarthritis and heart failure in mammals, for example when persisting cytoplasmic DNA is not degraded by DNaseII. We have recently identified inflammation-like responses to cytoplasmic DNA in the genetic model system C. elegans. We determined that the systemic functional deterioration is caused by a persistent innate immune response and we have discovered therapeutic interventions, whose efficacy will be assessed in mammalian models.

Clinical/medical relevance and sustainability in disease understanding

Chronic inflammation caused by immune responses to cytoplasmic DNA can result in polyarthritis and heart failure in humans. Systemic lupus erythematosus is a major health concern and is associated with anti-DNA antibodies indicating a causal role of inflammatory responses to DNA in the disease aetiology. Our research program will explore a new route for counteracting cellular and tissue damage caused by inflammation-associated protein folding stress and could open new therapeutic avenues.


Prof. Dr. rer. nat. Björn Schumacher

Institute for Genome Stability in Ageing and Disease, CECAD Cologne

Prof. Dr. rer. nat. Björn Schumacher

Work +49 221 478 84202

CECAD Research Center
Joseph-Stelzmann-Str. 26
50931 Cologne

http://schumacher.cecad-labs.uni-koeln.de/Home.66.0.html

Publications - Björn Schumacher

Link to PubMed


Dr. rer. nat. Ashley Williams

Inst. for Genome Stability in Aging and Disease, CECAD Cologne

Dr. rer. nat. Ashley Williams

Co-Principal Investigator B 5

awilliam@uni-koeln.de

Work +49 221 478 84205

CECAD Research Center
Joseph-Stelzmann-Str. 26
50931 Cologne

Publications - Ashley Williams

Link to PubMed