Dr. rer. nat. Sandra Iden - Curriculum Vitae

Education and professional career

since 2011: Principal Investigator, research group “Cell polarity and cancer”, CECAD Cologne, Faculty of Medicine, University of Cologne, Germany
2007 - 2010: Post-doctoral researcher, Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands (mentor: Dr. John G. Collard)
2007: Post-doctoral research, Institute of Medical Biochemistry,  University Hospital Muenster, Germany (mentor: Prof. Dr. Klaus Ebnet)
2007: PhD degree (Promotion Dr. rer.nat.), University of Muenster, Germany (summa cum laude)
2003 - 2007: PhD student, Institutes of Cell Biology and Medical Biochemistry,  University Hospital Muenster, Germany (mentor: Prof. Dr. Klaus Ebnet)
2003: Diploma in Biochemistry, University of Hannover, Germany; Diploma thesis, Max-Planck Institute for Experimental Endocrinology and University of Hannover, Germany
2003: Research trainee, Division of Neuroendocrinology, Max-Planck Institute for Experimental Endocrinology, and University of Hannover, Germany (mentors: Prof. K. Bauer and Dr. Heike Heuer)
2002: Research trainee, Center for Neurobiology and Behavior, Columbia University New York, USA (mentors: Prof. C. A. Mason, Dr. Heike Heuer)
1998 - 2003: Studies in Biochemistry (Diploma), University of Hannover, Germany

Awards, distinctions and professional activities

2017: "Careers and Diversity in Science in Academia and Industry", Career Panel Member Gordon Research Seminar “Epithelial Differentiation & Keratinization”, Italy
since 2016: Reviewer for ANR (project grants)
since 2015: Reviewer for DFG (project grants)
since 2015: Member of the SFB829 Executive Board
2015: Chair 31st Ernst-Klenk Symposium “Cell polarity and cell cycle control mechanism in development, tissue homeostasis and disease” 2015 (with Jay Gopalakrishnan)
2015: Co-organiser and symposium chair “International Meeting of the German Society of Cell Biology (DGZ)” 2015, Cologne
2015: Best Poster Award at Annual Meeting of the ESDR, Rotterdam, NL
2014: Coordination and organization of “2nd Ladies’ Science Club”, meeting of female junior group leaders heading a research group in Germany, Cologne
since 2013: Member of CECAD Executive Board
since 2013: Coordinator SFB829 Integrated Research Training Group (with Prof. T. Krieg)
2013: Reviewer for Prostate Cancer UK
since 2012: Reviewer for different scientific journals including Journal of Cell Biology, Oncogene, Current Biology, Journal of Cell Science, Nature Communications, Journal of Investigative Dermatology, Molecular Biology of the Cell, Biology Open
2011: Best Poster Award at 41st Annual Meeting of the ESDR, Barcelona, Spain

Selected publications

Mescher M, Jeong P, Knapp S, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden S: The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma..J Exp Med. 2017 Feb;214(2):339-358.                     

Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf, D.: Epithelial barriers in murine skin during Herpes simplex virus 1 infection: the role of tight junction formation. J Invest Dermatol, Dec 6. pii: S0022-202X(16)32775-0.
        
Ali NJA, Dias Gomes M, Bauer R, Brodesser S, Niemann C, Iden S: Essential role of polarity protein Par3 for epidermal homeostasis through regulation of barrier function, keratinocyte differentiation and stem cell maintenance J Invest Dermatol, 2016 Dec;136(12):2406-2416.                    

Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA: mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun. 2016 Oct 27;7:13226.                                                     

Schlereth S, Iden S, Mescher M, Ksander B, Bosch J, Cursiefen C, Heindl LM: A novel model of metastatic conjunctival melanoma in immune competent mice. Invest Ophthalmol Vis Sci. 2015 Sep 1;56(10):5965-73.                     

Refaian N, Schlereth S, Koch K, Notara M, Hos D, Mescher M, Iden S, Bosch J, Jager M, Cursiefen C, Heindl L: Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines. Invest Ophthalmol Vis Sci. 2015 Aug 1;56(9):5691-7.                           

Tuncay H, Brinkmann B, Steinbacher T, Schürmann A, Gerke V, Iden S, and Ebnet K: JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun. 2015 Aug 26;6:8128.                                                                           

Mescher M, Iden S: Par Proteins in Tumor Formation and Progression. Cell Polarity 2. Role in Development and Disease. Springer 2015, VIII. ISBN 978-3-319-14466-5. Book chapter.

Schlereth S, Refaian N, Iden S, Cursiefen C, Heindl LM: Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis. Biomed Res Int. 2014:639058.                             

Iden S*, van Riel WE, Schäfer R, Song J-Y, Hirose T, Ohno S, Collard JG: Tumor Type-Dependent Function of the Par3 Polarity Protein in Skin Tumorigenesis. Cancer Cell. 2012;22(3):389-403 *: corresponding author.                      

Niessen MT, Iden S, Niessen CM: The in vivo function of mammalian cell and tissue polarity regulators - how to shape and maintain the epidermal barrier. J Cell Science. 2012;125(Pt 15), 3501-3510.                        

Semler O, Garbes L, Keupp K, Swan D, Zimmermann K, Becker J, Iden S, Wirth B, Eysel P, Koerber F, Schoenau E, Bohlander SK, Wollnik B, Netzer C.: A Mutation in the 5'-UTR of IFITM5 Creates an In-Frame Start Codon and Causes Autosomal-Dominant Osteogenesis Imperfecta Type V with Hyperplastic Callus. Amer J Hum Gen. 2012;91(2):349-57.                           

Ellenbroek SIJ, Iden S, Collard JG: Cell polarity proteins and cancer. Sem Cancer Biol. 2012;22(3):208-215.                        

Ellenbroek SIJ, Iden S, Collard JG: The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network. Small GTPases 2012;3(1):4-14.

Iden S*, Misselwitz S*, Peddibhotla SSD, Tuncay H, Rehder D, Gerke V, Robenek H, Suzuki A, Ebnet K: aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. J Cell Biol. 2012;196(5):623-39. (*: equal contribution).                

Ebnet K, Gerke V, Iden S: Cadherins and the regulation of tight junctions and cell polarity Molecular and functional diversities of cadherin and protocadherin. 2010. ISBN: 978-81-308-0427-9. Book chapter.

Iden S, Collard JG:Crosstalk between small GTPases and polarity proteins in cell polarization. Nat Rev Mol Cell Biol. 2008;9(11):846-59.                         

Ebnet K, Iden S, Gerke V, Suzuki A: Regulation of epithelial and endothelial junctions by PAR proteins. Front Biosci. 2008;13:6520-36.                        

Pardo J, Wallich R, Ebnet K, Iden S, Zentgraf H, Martin P, Ekiciler A, Prins A, Mullbacher A, Huber M, Simon MM: Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin. Cell Death Differ. 2007;14(10):1768-79.                    

Mandicourt G, Iden S, Ebnet K, Aurrand-Lions M, Imhof BA: JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration. J Biol Chem. 2007;282(3):1830-7.