Prof. Dr. Reinhard Büttner - Curriculum Vitae

Education and professional career

2016: Co-President of the World Pathology Congress IAP / ESP in Cologne
since 2014: Chairman of the German-Baltic Society of Physicians
since 2011: Professor and Chair, Institute of Pathology, University of Cologne
2011 - 2013: President of the German Division, International Academy of Pathology
2010: Foundation of the Network Genomic Medicine (NGM)
since 2009: Executive Board, Mildred Scheel Cancer Foundation
2007 - 2009: Dean of the Medical Faculty, University of Bonn
2006 - 2013: Member of the Science Committee, Deutsche Forschungsgemeinschaft
2005: Co-Founder and Chief Scientific Officer, Targos Molec Pathology Inc
2001 - 2011: Professor and Chair, Institute of Pathology Bonn University
1999: C3-Professor for Pathology, RWTH Aachen University
1998 - 2001: Speaker of the DFG-Forschergruppe ‘Cell Death in Neuronal Systems’ University of Regensburg
1989 - 1990: DFG Research Fellow, MD Anderson Cancer Center, Houston Texas
1988 - 1989: Research Fellow, Gene Center Munich
1986: MD Thesis, Max-von-Pettenkofer Institute, Munich
1979 - 1985: Supported by the ‘Studienstiftung des Deutschen Volkes’

Selected publications

Peifer M, Hertwig F, Roels F,…, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O’Sullivan R, Westermann F, Thomas RK, Fischer M. Telomerase activation by genomic rearrangements in neuroblastoma. Nature. 2015, in press.

George J, Lim JS, Jang SJ,..., Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015, Aug 6;524(7563):47-53.

Dietlein F, Kalb B, Jokic M, Noll EM, Strong A, Tharun L, Ozretić L, Künstlinger H, Kambartel K, Randerath WJ, Jüngst C, Schmitt A, Torgovnick A, Richters A, Rauh D, Siedek F, Persigehl T, Mauch C, Bartkova J, Bradley A, Sprick MR, Trumpp A, Rad R, Saur D, Bartek J, Wolf J, Büttner R, Thomas RK, Reinhardt HC. Synergistic interactions between CHEK1- and MK2 inhibitors in KRAS mutant cancer. Cell. 2015, Aug 27;162(5):1169.

Kloth M, Ruesseler V, Engel C, Koenig K, Peifer M, Mariotti E, Kuenstlinger H, Florin A, Rommerscheidt-Fuss U, Koitzsch U, Wodtke C, Ueckeroth F, Holzapfel S, Aretz S, Propping P, Loeffler M, Merkelbach-Bruse S, Odenthal M, Friedrichs N, Heukamp LC, Zander T, Buettner R. Activating ERB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer. Gut. 2015, Apr 28. pii: gutjnl-2014-309026.

Vollbrecht C, Mairinger FD, Koitzsch U, Peifer M, Koenig K, Heukamp LC, Crispatzu G, Wilden L, Kreuzer KA, Hallek M, Odenthal M, Herling CD, Buettner R. Comprehensive analysis of disease-relates genes in Chronic Lymphycytic Leukemia by Next Gen sequencing. PloSOne. 2015, Jun 8;10(6):e0129544.

König K, Peifer M, Fassunke J,…, Buettner R, Heukamp LC. Implementation of amplicon parallel sequencing leads to improvement of diagnosis and therapy of lung cancer patients. JTO. 2015, Jul;10(7):1049-57.

Schildhaus HU, Schultheis AM, Rüschoff J, Binot E, Merkelbach-Bruse S, Fassunke J, Schulte W, Ko YD, Schlesinger A, Bos M, Gardizi M, Engel-Riedel W, Brockmann M, Serke M, Gerigk U, Hekmat K, Frank KF, Reiser M, Schulz H, Krüger S, Stoelben E, Zander T, Wolf J, Buettner R. MET-amplification in therapy-naïve adeno- and squamous cell carcinomas of the lung. Clin Cancer Res. 2015, Feb 15;21(4):907-15.

Fernandez-Cuesta L, Peifer M, Lu X,..., Buettner R, Thomas RK. Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Nat Comm. 2014, Mar 27;5:3518.

Lovly CM, McDonald NT, Chen H, Ortiz-Cuaran S, Heukamp LC, Yan Y, Florin A, Ozretić L, Lim D, Wang L, Chen Z, Chen X, Lu P, Paik PK, Shen R, Jin H, Buettner R et al. Rationale for co-targeting IGF-1R and ALK in ALK-fusion positive lung cancer. Nat Med. 2014, Sep;20(9):1027-34.