Reinhard Büttner / Margarete Odenthal - A 1

The multifaceted function of the lysine-specific histone demethylase 1 in lung cancer

Abstract

Epigenetic abnormalities play a vital role in the progression of many cancer types including non-small cell lung cancer (NSCLC), which is a leading cause of cancer-related mortality. Lysine-specific demethylase 1 (LSD1/KDM1A) acts as an epigenetic regulator and is overexpressed in a wide variety of cancer types.

By recent studies we have collected evidence that LSD1 is involved in lung adenocarcinoma initiation, which  is presently further analysed using a tumor-specific cell lineage tracking mouse model. Furthermore, LSD1 overexpression in NSCLC cell systems results in dysregulation of long non-coding (lnc)RNA. In order to evaluate lncRNA as markers for NSCLC prognosis or as novel therapeutic targets, lncRNA profiles and functions will be deeply studied on NSCLC cell systems, transgenic mice tumor models and human specimens. By comprehensive studies of protein and RNA interaction profiles, we will additionally  address the LSD1 impact on transcript processingin NSCLC cancer cells, providing new insights in LSD1 mediated oncogenic alterations.

Clinical/medical relevance and sustainability in disease understanding

Epigenetic alterations and histone modifications are crucial for lung cancer initiation, progression, and metastasis. In order to provide novel options for early lung cancer detection and intervention, the project addresses the function of the histone modifier LSD1 as a central promoter of lung cancer development. In particular, we will shed light on the mechanistic insights of the regulatory impact of LSD1 on oncogenic signaling, revealing novel therapeutic strategies for future treatments.


Prof. Dr. med. Reinhard Büttner

Institute for Pathology

Prof. Dr. med. Reinhard Büttner

Principal Investigator A 1
Executive Board Member

reinhard.buettner@uk-koeln.de

Work +49 221 478 6320

Fax (Work) +49 221 478 6360

Institute for Pathology
Kerpener Str. 62
50937 Cologne

https://pathologie.uk-koeln.de/institut/

Publications - Reinhard Büttner

Link to PubMed


Prof. Dr. rer. nat. Margarete Odenthal

Institute for Pathology

Prof. Dr. rer. nat. Margarete Odenthal

Co-Principal Investigator A 1

margarete.odenthal@uk-koeln.de

Work +49 221 478 6351

Fax (Work) +49 221 478 6360

Institute for Pathology
Kerpener Str. 62
50937 Cologne

Publications - Margarete Odenthal

Link to PubMed