Olaf Utermöhlen - assoc. RG

Pathogenicity of Zika Virus strains in various host cell types

Abstract

The emergence of Zika virus (ZIKV) in Central America in 2015 coincided with a surge in the incidence of microcephaly. A growing body of epidemiological and experimental evidence strengthens the assumption that prenatal ZIKV infection causes microcephaly.
This project aims at characterizing the pathogenicity of ZIKV in neurologically relevant cells. Furthermore, it is still an open question, whether Zika isolates from Africa versus Asia/South America differ in their pathogenicity.
We have a collection of ZIKV strains from recent outbreaks in Polynesia and Central America and from endemic areas in Africa. Additionally, we have different cell cultures systems for neurologically relevant cell types. With these experimental systems, we will elucidate whether specific ZIKV strains differ in their pathogenicity and we will characterize underlying molecular mechanisms.
This project will provide a contribution to understanding the impact of ZIKV infection on brain development, which is required for prophylactic and therapeutic approaches against the sequelae of the global ZIKV epidemics.

Clinical/medical relevance and sustainability in disease understanding

Accumulating epidemiological evidence and data from in vitro models of human brain development suggest that prenatal Zika virus infection causes severe fetal brain malformations, including microcephaly. Virological aspects as well as the cellular and molecular mechanisms of the impact of ZIKV infection on brain development need to be characterized in order to assess target-oriented prophylactic and/or therapeutic approaches to prevent ZIKV-induced fetal malformations in the future.


Prof. Dr. med. Olaf Utermöhlen

Inst. for Med. Microbiology, Immunology and Hygiene

Prof. Dr. med. Olaf Utermöhlen

Executive Board Member
assoc. CMMC Research Group

olaf.utermoehlen@uk-koeln.de

Work +49 221 478 32023

Fax (Work) +49 221 478 32002

Institute for Medical Microbiology, Immunology and Hygiene
Goldenfelsstr. 19 – 21
50935 Cologne

http://immih.uk-koeln.de/forschung/ag-utermoehlen

Publications - Olaf Utermöhlen

Link to PubMed