Prof. Dr. med. Dr. rer. nat. Michal-Ruth Schweiger - Curriculum Vitae

Education and professional career

since 2014: Professor for Translational Epigenomics, Cologne
since 2015: Attending physician, Human Genetics, University Hospital Cologne
2015: Board examination in Human Genetics (Charité University Hospital, Berlin)
2013: Habilitation in experimental medicine at the Charité University Hospital, Berlin
2008 - 2014: Residency in Medical Genetics, Charité University Hospital, Berlin
2007 - 2014: Junior Research group leader ‘cancer genomics’, Department Vertebrate Genomics, MPI for Molecular Genetics, Berlin
2008: M.D. (Dr.med.) Harvard Medical School Boston and FU Berlin (summa cum)
2005 - 2007: Postdoctoral research fellow with Peter M. Howley, Harvard Medical School Boston, Pathology, Boston, USA
2002 - 2005: Ph.D. (Dr.rer.nat.) Peter M. Howley, Harvard Medical School Boston, FU Berlin (summa cum)
2002: Master degree in Biochemistry (Diplom) Dep. of Clinical Chemistry, Innsbruck, Austria
1995 - 2002: Biochemistry studies FU Berlin
1994 - 2001: Medical School FU Berlin and Charité University Hospital, Berlin

Awards, distinctions and professional activities

since 2014: W2 Lichtenberg Professorship
2008: Robert Koch Charité dissertation award
2003 - 2005: Fellowship from the ‘Studienstiftung des deutschen Volkes’
1999 - 2002: Teaching assistant (tutor) in Biochemistry for Medical Students and in Molecular Biology for Bioinformatics students
1995 - 1999: Student research training program at the MPI for Molecular Genetics

Selected publications

Lienhard M*, Grasse S*, Rolff J, Frese S, Schirmer U, Becker M, Börno S, Timmermann B, Chavez L, Sültmann H, Leschber G, Fichtner I, Schweiger MR*, Herwig R*.: QSEA-modelling of genome-wide DNA methylation from sequencing enrichment experiments. Nucleic Acids Res. 2017, Vol: 45(6).
* co-shared authorship

Hussong M*, Kaehler C*, Kerick M, Grimm C, Franz A, Timmermann B, Welzel F, Isensee J, Hucho T, Krobitsch S*, Schweiger MR.*: The bromodomain protein BRD4 regulates splicing during heat shock. Nucleic Acids Res. 2017, Vol: 45(1).
* co-shared authorship

Castelo-Branco P, Leão R, Lipman T, Campbell B, Lee D, Price A, Zhang C, Heidari A, Stephens D, Boerno S, Coelho H, Gomes A, Domingos C, Apolonio JD, Schäfer G, Bristow RG, Schweiger MR, Hamilton R, Zlotta A, Figueiredo A, Klocker H, Sültmann H, Tabori U.: A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: a retrospective cohort study. Oncotarget 2016, Vol:7(36).

Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Krämer A, Roncaioli JL, Sand F, Heuckmann JM, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmüller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E, Henrich KO, Gloeckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Höfer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O'Sullivan RJ, Westermann F, Thomas RK, Fischer M.: Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature 2015, Vol:526 (7575).

Zemojtel T, Köhler S, Mackenroth L, Jäger M, Hecht J, Krawitz P, Graul-Neumann L, Doelken S, Ehmke N, Spielmann M, Oien NC, Schweiger MR, Krüger U, Frommer G, Fischer B, Kornak U, Flöttmann R, Ardeshirdavani A, Moreau Y, Lewis SE, Haendel M, Smedley D, Horn D, Mundlos S, Robinson PN.: Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome. Sci Transl Med. 2014, Vol:6(252).

Hussong M, Börno ST, Kerick M, Wunderlich A, Franz A, Sültmann H, Timmermann B, Lehrach H, Hirsch-Kauffmann M, Schweiger MR.: The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. Cell Death Dis.2014, Vol:5.

Börno ST, Fischer A, Kerick M, Fälth M, Laible M, Brase JC, Kuner R, Dahl A, Grimm C, Sayanjali B, Isau M, Röhr C, Wunderlich A, Timmermann B, Claus R, Plass C, Graefen M, Simon R, Demichelis F, Rubin MA, Sauter G, Schlomm T, Sültmann H, Lehrach H, Schweiger MR.: Genome-wide DNA methylation events in TMPRSS2-ERG fusion-negative prostate cancers implicate an EZH2-dependent mechanism with miR-26a hypermethylation. Cancer Discov.2012, Vol:2(11).

Kerick M, Isau M, Timmermann B, Sültmann H, Herwig R, Krobitsch S, Schaefer G, Verdorfer I, Bartsch G, Klocker H, Lehrach H, Schweiger MR.: Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity. BMC Med Genomics 2011, Vol:4(68).

Timmermann B, Kerick M, Roehr C, Fischer A, Isau M, Boerno ST, Wunderlich A, Barmeyer C, Seemann P, Koenig J, Lappe M, Kuss AW, Garshasbi M, Bertram L, Trappe K, Werber M, Herrmann BG, Zatloukal K, Lehrach H, Schweiger MR.: Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PloS One 2010, Vol:5(12).

Krawitz PM*, Schweiger MR*, Rödelsperger C, Marcelis C, Kölsch U, Meisel C, Stephani F, Kinoshita T, Murakami Y, Bauer S, Isau M, Fischer A, Dahl A, Kerick M, Hecht J, Köhler S, Jäger M, Grünhagen J, de Condor BJ, Doelken S, Brunner HG, Meinecke P, Passarge E, Thompson MD, Cole DE, Horn D, Roscioli T, Mundlos S, Robinson PN.: Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. Nat Genet. 2010, Vol 42(10).
*co-shared authorship

Schweiger MR, Kerick M, Timmermann B, Albrecht MW, Borodina T, Parkhomchuk D, Zatloukal K, Lehrach H.: Genome-wide massively parallel sequencing of formaldehyde fixed-paraffin embedded (FFPE) tumor tissues for copy-number- and mutation-analysis. PloS One 2009, Vol:4(5).

Schweiger MR, You J, Howley PM.: Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol. 20016, Vol:80(9).