Prof. Dr. rer. nat. Manolis Pasparakis - Curriculum Vitae

Education and professional career

2010 - 2011: Acting Director, Institute for Genetics, University of Cologne
2010 - 2011: Elected Vice Chair of the Centre of Molecular Medicine, University of Cologne
since 2005: Professor, Institute for Genetics, University of Cologne
2002 - 2005: Group Leader, European Molecular Biology Laboratory (EMBL), Mouse Biology Unit, Monterotondo (Rome), Italy
1997 - 2001: Post-doctoral fellow, advisor Professor Klaus Rajewsky, Institute for Genetics, University of Cologne, Germany
1997: Ph.D. degree in Biology, University of Athens, Athens, Greece
1993 - 1997: Ph.D. thesis work, advisor Dr. George Kollias, Hellenic Pasteur Institute, Athens, Greece
1992: Diploma in Biology, University of Athens

Awards, distinctions and professional activities

2013: ERC Advanced Grant
2012 - 2014: ERC Life Sciences Consolidator Grants, LS4 Panel Chair
since 2011: Editorial Board, EMBO Molecular Medicine
2009 - 2016: Member of the Committee for Good Scientific Practice, University of Cologne
2009 - 2012: ERC Life Sciences Starting Grants, LS4 Panel Member
2009 - 2012: Editorial Board, European Journal of Immunology
2008: Elected Member of the European Molecular Biology Organisation (EMBO)
since 2008: Member of the Internal Scientific Advisory Council, University of Cologne
2008: Departmental Advisory Board, Department for Molecular Biomedical Research, VIB, Gent, Belgium
2005: Chair of the external departmental evaluation board, Department for Molecular Biomedical Research, VIB, Gent, Belgium
2000 - 2001: The Leukemia & Lymphoma Society, Special Postdoctoral Fellowship
1997 - 1999: EMBO long-term postdoctoral fellowship

Selected publications

Lin J, Kumari S, Kim C, Van T-M, Wachsmuth L, Polykratis A, and Pasparakis M. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016, 540: 124-128.

Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M, and Pasparakis M. NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-?B-Dependent and -Independent Functions. Immunity. 2016, 44: 553–567.

Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van T-M, Curth H-M, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, and Pasparakis M. NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015 28: 582–598.

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher, and Pasparakis M. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014 513: 90–94.
 
Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernandez-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, and Pasparakis M. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature. 2011 477: 330-334.

Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, and Pasparakis M.  The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation. Immunity. 2011, 35: 572-582.

Gareus R, Kotsaki E, Xanthoulea S, van der Made I, Gijbels MJ, Kardakaris R, Polykratis A, Kollias G, de Winther MP, and Pasparakis M. Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab. 2008, 8: 372–383.

Ermolaeva MA, Michallet MC, Papadopoulou N, Utermohlen O, Kranidioti K, Kollias G, Tschopp J, and Pasparakis M. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol. 2008, 9: 1037-1046.

Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, and Pasparakis M. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 2007, 446: 557-561.

Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, and Pasparakis M. (2007) Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell. 2007, 11: 119-132.