The CMMC research areas

The three CMMC research areas enhance and strengthen innovative molecular research with clinical reference

The CMMC fosters interdisciplinary collaboration from the laboratory to the clinic as well as offers an exceptional training ground for the next generation of scientists and clinicians having a strong interest in and firm commitment to biomedical research. The research projects supported by the different funding programs are grouped within three CMMC core research areas:

Research Area A

Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

Bazzi, Hisham - A 01
The mitotic surveillance pathway in stem cells
Bergami, Matteo | Motori, Elisa - A 02
Role of synaptic hijacking in SCLC brain metastatic growth
Büttner, Reinhard | Kondylis, Vangelis - A 03
Systematic mapping of the p62-KEAP1-NRF2 axis and co-regulated pathways across human cancers
Brägelmann, Johannes - CAP 18
Dissecting the molecular mechanisms of tumor evolution and therapy resistance
Bozek, Katarzyna - assoc. RG 33
Data Science of Bioimages
Escobar-Henriques, Mafalda - CAP 14
Role of mitofusin 2 in health and disease
Fischer, Matthias - A 04
Elucidating the mechanisms of spontaneous regression and differentiation in neuroblastoma using genetically engineered mouse models
Frenzel, Lukas | Hallek, Michael - A 05
The dialogue of CLL cells with the tumor microenvironment as a mediator of treatment resistance against targeted inhibitor combinationslls
Grüll, Holger - assoc. RG 41
Hillmer, Axel | Büttner, Reinhard - A 06
Identification of therapeutic vulnerabilities of KEAP1-mutated lung adenocarcinoma
Jachimowicz, Ron - assoc. RG 36
Kath-Schorr, Stephanie - assoc. RG 42
von Karstedt, Silvia - A 07
Targeting the Necroptosis Pathway in Pancreatic Cancer
Kurian, Leo - A 08
Engineering mRNA translation specialization modules to ameliorate pathological cardiac hypertrophy: from pathomechanisms to clinical targets, and off-the-shelf therapeutic strategies
Nguyen, Phuong-Hien | Renata Stripecke | Alessandro Annibaldi - A 09
Understanding the multifaceted regulation of T cell immunity in B cell lymphoma for improved immunotherapy
Nguyen, Phuong-Hien - CAP 19
Deciphering the functional relevance and signal transduction network of protein kinases in the tumor microenvironment
Niemann, Catherin - assoc. RG 14
Stem cell and cancer biology
Notara, Maria - CAP 15
Effects of UV irradiation on corneal angiogenic privilege: pterygium as a UV-induced stem cell disease model: The limbal niche and corneal avascularity
Pallasch, Christian P - assoc. RG 15
Peifer, Martin - assoc. RG 16
Computational cancer genomics
Peltzer, Nieves - assoc. JRG 03 and CAP 24
Cell death and inflammation in health and disease
Poepsel, Simon - JRG 11
Structure and biochemistry of epigenetic regulators
Schmutzler, Rita - assoc. RG 20
Investigation of the genetic causes of breast and ovarian cancer
Schumacher, Björn - A 10
Bypassing hotspot mutated p53
Schweiger, Michal-Ruth assoc. RG 35
Thomas, Roman - assoc. RG 22
Lung Cancer Genomics
Ullrich, Roland - assoc. RG 23
Targeting tumor angiogenesis
Wunderlich, F Thomas - A 11
The crosstalk between marginal zone B cells and female hormonal state in the development of benign liver cancer
Wodarz, Andreas - assoc. RG 24
Molecular control of cell polarity in epithelia and stem cells
Grosskopf-Kroiher, Debora | Mauch, Cornelia - PP 1
Cancer Prevention Project: Die Sonne und Wir

Research Area B

Principles of immunity, inflammation and infection

Annibaldi, Alessandro - JRG 12
Understanding the role of cell death in health and disease
Baldus, Stephan - assoc. RG 01
Inflammatory pathways in ischemia- and chemotherapy-induced heart failure - the role of extracellular vesicles as carriers of leukocyte-derived peroxidases
Bock, Felix - assoc. RG 04
Local Immune Modulation in Experimental Ophthalmology
Brähler, Sebastian - CAP 17
Immunobiology of glomerular diseases
Brinkkötter, Paul T | Brähler, Sebastian - B 01
Inflammatory signaling in the PDSS2-model of metabolic podocyte damage – from mouse models to human biopsy analysis
Cabreiro, Filipe | Corrado, Mauro | Solagna, Francesca - B 02
Role of gut microbiota on the onset of sarcopenia
Chmielewski, Markus - assoc. RG 30
High efficient and safe CAR T cells for treatment of tumors
Cornely, Oliver A - assoc. RG 28
Translational research in compromised immunity and immune responses
Corrado, Mauro - CAP 21
Investigating the metabolic determinants of T cell immunological memory
Corrado, Mauro - B 03
Epigenetic-metabolic crosstalk in the development of T cell immunological memory
Cursiefen, Claus | Hadrian, Karina | Hos, Deniz - B 04
Targeting the osmosensitive transcription factor NFAT5 in acute and chronic corneal edema
Hombach, Andreas - assoc. RG 29
Designing smart CAR T cells for improved clinical efficiency
Hoyer, Friedrich F - CAP 22
Myeloid Leukocytes in Cardiovascular and Systemic Inflammation
Jantsch, Jonathan - B 05
Endothelial cells and pericytes in cutaneous leishmaniasis
Kashkar, Hamid - B 06
Role of IAPs in TNF-induced vasculature alteration and their therapeutic value in inflammatory diseases
Klein, Florian - assoc. RG 10
Antibody-mediated therapy and prevention of infectious pathogens
Krönke, Martin - SRG 03
Metabolic Virulence of Staphylococcus aurea
Langmann, Thomas | Wolf, Anne - B 07
Retinal microglia and their immunological effects in AAV-based ocular gene therapy
Liccardi, Gianmaria - assoc. RG 43
Maier, Berenike | Higgins, Paul - B 08
Correlating biofilm structure with antibiotic tolerance
Pasparakis, Manolis - B 09
Role of autophagy in the regulation of ZBP1-mediated cell death and inflammation
Rybniker, Jan | Theobald, Sebastian - B 10
Deciphering and modulating innate and adaptive immune crosstalk in SARS-CoV-2 vaccination
Schlößer, Hans A - assoc. RG 45 (former CAP 12)
Tumor-specific endogenous immune response and immune escape in gastrointestinal Cancer
Schommers, Philipp - assoc. JRG 07 and CAP 26
Laboratory of Antiviral Immunity
Simonis, Alexander - assoc. JRG 09 and CAP 27
Novel immunotherapeutic approaches in the treatment of severe bacterial infections
Trifunovic, Aleksandra - B 11
Role of mitochondria in the regulation of innate immunity responses
Winkels, Holger | Mollenhauer, Martin - B 12
Olfr2-mediated macrophage activation in obesity induced endothelial dysfunction

Research Area C

Molecular mechanisms and metabolic control of tissue degeneration and regeneration

Alcazar, Miguel A Alejandre
Netrin-1 as a new target to treat chronic lung disease: Identification of agonists and antagonists by artificial intelligence
Antczak, Philipp - assoc. JRG 06 and CAP 20
Understanding the molecular basis of stress, longevity, and aging
Benzing, Thomas - C 01
Pressure-dependent proteostasis regulation in podocytes at the kidney filtration barrier and the pathogenesis of albuminuria
Beyer, Andreas | Hänsel-Hertsch, Robert - C 02
Detecting transcriptional mistakes of RNA Polymerase-II at the single-cell level
Brüning, Jens C - C 03
Identification and characterization of the specific subpopulation of prepronociceptin (PNOC)-expressing neurons responsible for the development of diet-induced obesity
Clahsen, Thomas - assoc. RG 05
Identification of novel endogenous modulators of developmental and inflammatory lymphangiogenesis by analyzing mouse strain-specific differences
Eming, Sabine | Fabri, Mario - C 04
Unlocking tissue protective and regenerative functions of myeloid cells by metabolic reprograming
Fischer, Dietmar - assoc. RG 43
Validation of a new natural class of compounds for therapeutic use in nerve regeneration
Gehring, Niels - C 05
Function of nonsense-mediated mRNA decay in brain development and neurological disease
Hammerschmidt, Matthias - C 06
Novel pathomechanisms of spine abnormalities and intervertebral disc degeneration caused by mutations in the fatty acid synthase gene
Haensel-Hertsch, Robert - JRG 10
(Epi)Genome structure and stability
Hoppe, Thorsten - C 07
Understanding the pathomechanism of spinocerebellar ataxia caused by inherited mutations in the ubiquitin ligase CHIP
Isbrandt, Dirk - assoc. RG 39
Krieg, Thomas - SRG 02
The role of activated fibroblasts in fibrosis – scleroderma as a model disease
Kononenko, Natalia - C 08
Dissecting the role of Alzheimer’s disease-associated endocytosis risk factors in regulating cell cycle events in neuronal cells
Korotkova, Tatiana | Schaefer, Anne - C 09
Regulation of neuronal activity, cognitive and social functions by microglia in health and pathology
Krüger, Marcus - assoc. RG 40
Lemberg, Marius | Schiavinato, Alvise | Nüchel, Julian - C 10
Triaging of secretory cargo by interplay of TANGO1 and ERAD-R
Liebau, Max C | Schermer, Bernhard C 11
Understanding the mechanisms underlying early kidney failure in ARPKD
Maleki, Hajar - assoc. JRG 08
Functional Bio-inspired Porous Materials
Müller, Roman-Ulrich - assoc. RG 13
Hypoxia-signaling at the crossroads of cellular stress resistance and tumorigenesis
Niessen, Carien M | Hanßen, Ruth - C 12
Skin insulin resistance in type II diabetes and its associated diseases
Pfannkuche, Kurt P - assoc. RG 17
Cardiac tissue engineering
Pla-Martín, David - CAP 25
Modulate mitochondrial quality control to decelerate disease progression
Rosenkranz, Stephan | Vantler, Marius - C 13
Role of TNF-mediated inflammatory signaling in heart failure with preserved ejection fraction (HFpEF) and associated pulmonary hypertension (PH)
Rugarli, Elena I - C 14
Mapping hereditary spastic paraplegia: towards common pathogenic and novel rescue pathways
Schwarz, Guenter - C 15
Development of treatments for molybdenum cofactor and sulfite oxidase deficiency
Sengle, Gerhard - assoc. RG 21
New molecular mechanisms of fibrosis
Stoffel, Wilhelm - SRG 01
Antagonistic pleiotropy of the Δ6-fatty acid desaturase (fads2) gene in disease and senescence. ω3- and ω6-Polyunsaturated fatty acids in Δ6-fatty acid desaturase (fads2-/-) deficiency
Trentini Schmidt, Débora B - assoc. JRG 05
Protein quality control and stress response
Trifunovic, Aleksandra | Szczepanowska, Karolina - C 15
Manipulation of CLPP protease to complement mitochondrial respiratory deficiency
Vilchez, David - C 16
Correction of alterations in the ubiquitinated proteome to prevent age-related neurodegenerative diseases
Vogt, Johannes | Kepser, Lara-Jane - C 17
Bioactive lipid signaling in adult neurogenesis and metabolic modulation
Wirth, Brunhilde | Piano, Valentina - C 18
Vesicular trafficking and axonal local translation in health and motor neuron disease

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