The CMMC research areas

The three CMMC research areas enhance and strengthen innovative molecular research with clinical reference

The CMMC fosters interdisciplinary collaboration from the laboratory to the clinic as well as offers an exceptional training ground for the next generation of scientists and clinicians having a strong interest in and firm commitment to biomedical research. The research projects supported by the different funding programs are grouped within three CMMC core research areas:

Research Area A: Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

Reinhard Büttner / Margarete Odenthal - A 1

The multifaceted function of the lysine-specific histone demethylase 1 in lung cancer

Mathieu Clement-Ziza - CAP 2

Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

Alexander Drzezga - assoc. RG

Title of the associated project: CXCR4 in kidney tumors

Matthias Fischer - A 2

The functional and therapeutic significance of activated telomerase in neuroblastoma

Jay Gopalakrishnan - JRG IX

Mechanisms and regulation of centrosome biogenesis

Michael Hallek / Phoung-Hien Nguyen - A 3

Comprehensive analyses of the mechanistic role of LYN kinase in B cell malignancies

Matthias Hammerschmidt - A 4

The multiple facets of the type II transmembrane serine protease ST14 and hypotonic stress during carcinogenesis in fish and mammals

Marco Herling / Elena Vasyutina - A 5

Context-specific mechanisms of the TCL1 oncogene in T- and B-cell leukemias

Sandra Iden - A 6

Requirement of polarity networks in melanoma cell plasticity, therapy and drug resistance

Catherin Niemann - A 7

Mechanisms of stem cell-specific gatekeeper functions in cancer initiation

Christian P Pallasch - CAP 5

Functional implications and interaction of macrophages in the tumor microenvironment upon genotoxic stress

Manolis Pasparakis - A 8

Immunogenic properties of necroptosis and apoptosis in stimulating anti-tumor immunity

Martin Peifer / H Christian Reinhardt - A 9

Exploring actionable cooperating lesions that drive Myd88-mediated lymphomagenesis

Martin Peifer - CAP 6

Systematic identification of significantly mutated gene groups in cancer genomes by co-expression patterns

Stephan Rosenkranz - CAP 7

Role of PI3Kd in atherosclerosis

Michal-Ruth Schweiger - A 10

Epigenetic mechanisms of genomic instability and therapy resistance in cancer

Martin Sos - A 11

Genomic and molecular characterization of the evolutionary process of drug resistance in EGFR-mutant lung cancer

Mirka Uhlirova - A 12

Cutting through the tumor complexity: Role of splicing in epithelial homeostasis and tumorigenesis

Roland Ullrich - CAP 9

Targeting tumor angiogenesis

Olaf Utermöhlen - assoc. RG

Pathogenicity of Zika Virus strains in various host cell types

Research Area B: Principles of immunity, inflammation and infection

Hinrich Abken - B 1

Metabolic addiction and reprogramming of an anti-tumor T cell response

Stephan Baldus / Martin Mollenhauer / Volker Rudolph - B 2

Inflammatory pathways propagating ventricular arrhythmia - the role of myeloperoxidase for postischemic pro-arrhythmic remodeling

Claus Cursiefen / Felix Bock / Deniz Hos - B 3

Novel therapeutic role of myeloid cell-derived VEGF-C and lymphangiogenesis in resolution of corneal inflammation and reestablishment of corneal transparency

Ludwig Eichinger - assoc. RG

Analysis of the function of p97/VCP in Dictyostelium discoideum

Hamid Kashkar - B 4

The role of mitochondrial apoptosis in macrophages and macrophage-derived tumor-promoting inflammation

Florian Klein - assoc. RG

Antibody-mediated therapy and prevention of infectious pathogens

Thomas Langmann - assoc. RG

Interferon-beta signaling in microglia as novel therapeutical concept for age-related macular degeneration

Helmar Lehmann - CAP 3

Mechanisms of axonal injury in neuroinflammation and neurotoxicity

Argyris Papantonis - JRG VIII

Towards a structure-to-function code for mammalian genomes

Björn Schumacher / Ashley Williams - B 5

Chronic inflammatory responses to persistent cytoplasmic DNA

Research Area C: Molecular mechanisms and metabolic control of tissue degeneration and regeneration

Bodo Beck / Janine Altmüller - C 1

Rare renal disorders identify core aspects of renal homeostasis - an integral approach to discover fundamental molecular principles of the kidney

Thomas Benzing / Matthias Hackl - C 2

The role of slit diaphragm signalling of podocytes

Matteo Bergami - C 3

Role of astrocytes in microvasculature remodeling following brain injury

Andreas Beyer / Argyris Papantonis - C 4

Contribution of deteriorating RNA biosynthesis to cellular ageing

Paul T Brinkkötter - C 5

Metabolic signaling at the kidney filtration barrier – role of insulin signaling on glomerular podocytes

Jens C Brüning - C 6

Fto-dependent regulation of hypothalamic neurons

Sabine Eming / Maria Leptin - C 7

The role of TOR pathway components in skin function

Dirk Isbrandt / Adele M Rüger / Michael Schroeter / Igor Jakovcevski - C 8

Novel roles for HCN/h- and Kv7/M-currents in the development of the cerebral cortex

Leo Kurian - assoc. JRG II

Molecular basis of vertebrate cardiac development, aging, and regeneration

Thomas Langer - C 9

Impaired mitochondrial proteostasis in CLPB associated disease

Carien M Niessen - C 10

Regulation of cell and tissue architecture in skin homeostasis, regeneration and degeneration

Angelika Noegel / Peter Nürnberg - C 11

Role of Wnt signaling in the etiology of Filippi syndrome and ectrodactyly ectodermal dysplas

Alvaro Rada-Iglesias - JRG VII

Genomic context and mechanisms of transcriptional repression during early patterning of the mammalian embryo

Jan Rybniker - CAP 8

Comprehensive host-cell based antibiotic drug discovery

Bernhard Schermer / Max C Liebau - C 12

The role of the cilia-cell-cycle connection in tissue homeostasis of renal tubular epithelium in acute and chronic kidney diseases

Guenter Schwarz - C 13

Sulfite oxidase-dependent nitric oxide synthesis: Molecular mechanism, in vivo relevance and pharmacological targeting

Gerhard Sengle / Raimund Wagener / Mats Paulsson - C 14

Extracellular microfibrillar systems in disease pathogenesis: functional interactions in cytokine regulation, cellular differentiation and tissue homeostasis

Wilhelm Stoffel - SRG 1

Genetically determined lipid structures and membrane functions in neuronal and extraneuronal tissues studied in null mouse models

Aleksandra Trifunovic - C 15

Manipulation of CLPP protease to complement mitochondrial respiratory deficiency

Brunhilde Wirth - C 16

Unraveling the molecular and cellular mechanism underlying spinal muscular atrophy by use of genetic modifiers