New Funding Period (1/2017-12/2019)

Overview of the individual funded projects

(funding period 01/2017 - 12/2019)

Research Area A:

Mechanisms of tumor development: intrinsic control of cell proliferation and tissue invasion

Büttner, Reinhard / Odenthal Margarethe - A 1

Institute for Pathology
The multifaceted function of lysine-specific histone demethylase 1 in lung cancer

Fischer, Matthias - A 2

Dept. of Children and Adolescent Medicine
The functional and therapeutic significance of activated telomerase in neuroblastoma

Hallek, Michael / Nguyen, Phoung-Hien - A 3

Dept. I of Internal Medicine
Comprehensive analyses of the mechanistic role of LYN kinase in B cell malignancies

Hammerschmidt, Matthias - A 4

Institute for Zoology
The multiple facts of the type II transmembrane serine protease ST14 and hypotonic stress during carcinogenesis in fish and mammals

Herling, Marco / Vasyutina, Elena - A 5

Dept. for Internal Medicine I
Context-specific mechanisms of the TCL1 oncogene in T- and B-cell leukemias

Iden, Sandra - A 6

CECAD Cologne
Requirement of polarity networks in melanoma cell plasticity, therapy and drug resistance

Niemann, Catherin - A 7

Institute for Biochemistry and CMMC
Mechanisms of stem cell-specific gatekeeper functions in cancer initiation

Pasparakis, Manolis - A 8

Institute for Genetics / CECAD Cologne
Immunogenic properties of necroptosis and apoptosis in stimulating anti-tumor immunity

Peifer, Martin1 / Reinhardt2, Christian - A 9

Dept. for Translational Genomics1 / Dept. I for Internal Medicine2
Exploring actionable cooperating lesions that drive Myd88-mediated lymphomagenesis

Schweiger, Michal-Ruth - A 10

Institute for Epigenomics
Epigenetic mechanisms of genomic instability and therapy resistance in cancer

Sos, Martin - A 11

Institute for Pathology
Genomic and molecular characterization of the evolutionary process of drug resistance in EGFR-mutant lung cancer

Uhlirova, Mirka - A 12

Institute for Genetics - CECAD Cologne
Cutting through the tumor complexity: Role of splicing in epithelial homeostasis and tumorigenesis

Research Area B

Principles of immunity, inflammation and infection

Abken, Hinrich  - B 1

Dept. I of Internal Medicine
Metabolic addiction and reprogramming of an anti-tumor T cell response

Baldus, Stephan / Mollenhauer, Martin / Rudolph, Volker - B 2

Dept. III of Internal Medicine
Inflammatory pathways propagating ventricular arrhythmia  - the role of myeloperoxidase for postischemic pro-arrhythmic remodeling

Cursiefen, Claus / Bock, Felix / Hos, Deniz - B 3

Dept. of Ophthalmology
Novel therapeutic role of myeloid cell-derived VEGF-C and lymphangiogenesis in resolution of corneal inflammation and reestablishment of corneal transparency

Kashkar, Hamid - B 4

Institute for Medical Microbiology, Immunology and Hygiene
The role of mitochondrial apoptosis in macrophages and macrophage-derived tumor-promoting inflammation

Schumacher, Björn / Williams, Ashley - B 5

Institute for Genome Stability in Aging and Disease, CECAD Cologne
Chronic inflammatory responses to persistent cytoplasmic DNA

Research Area C

Molecular mechanisms and metabolic control of tissue degeneration and regeneration

Beck, Bodo1 / Altmülller2, Janine - C 1

Institute for Human Genetics1 / Cologne Center for Genomics2
Rare renal disorders identify core aspects of renal homeostasis - an integral approach to discover fundamental molecular principles of the kidney

Benzing, Thomas / Hackl, Matthias - C 2

Dept. II of Internal Medicine
The role of slit diaphragm signalling of podocytes

Bergami, Matteo - C 3

CECAD Cologne
Role of astrocytes in microvasculature remodeling following brain injury

Beyer, Andreas1 / Papantonis2, Argyris - C 4

CECAD Cologne1 / CMMC2
Contribution of deteriorating RNA biosynthesis to cellular ageing

Brinkkötter, Paul T - C 5

Dept. II of Internal Medicine
Metabolic signaling at the kidney filtration barrier – role of insulin signaling on glomerular podocytes

Brüning, Jens C - C 6 

Center for Clinical Endocrinology, Diabetology and Preventative Medicine
Fto-dependent regulation of hypothalamic neurons

Eming1, Sabine / Leptin2, Maria - C 7

Dept. of Dermatology1 / Institute for genetics2
The role of TOR pathway components in skin function

Isbrandt, Dirk1 / Rüger2, Adele M / Schroeter2, Michael / Jakovcevski1, Igor - C 8

Institute for Molecular and Behavioral Neuroscience1 / Dept. of Neurology2
Novel roles for HCN/h- and Kv7/M-currents in the development of the cerebral cortex

Langer, Thomas - C 9

Institute for Genetics
Impaired mitochondrial proteostasis in CLPB associated disease

Niessen, Carien - C 10

Dept. of Dermatology
Regulation of cell and tissue architecture in skin homeostasis, regeneration and degeneration

Noegel1, Angelika / Nürnberg2, Peter - C 11

Institute for Biochemistry I1 / Cologne Center for Genomics2
Role of Wnt signaling in the etiology of Filippi syndrome and ectrodactyly ectodermal dysplasia

Schermer, Bernhard1 / Liebau2 Max C - C 12

Dept. II for Internal Medicine / Dept. of Children and Adolescent Medicine2
The role of the cilia-cell-cycle connection in tissue homeostasis of renal tubular epithelium in acute and chronic kidney diseases

Schwarz, Guenter - C 13

Institute for Biochemistry
Sulfite oxidase-dependent nitric oxide synthesis: Molecular mechanism, in vivo relevance and pharmacological targeting

Sengle, Gerhard / Wagener, Raimund / Paulsson, Mats - C 14

Institute for Biochemistry I
Extracellular microfibrillar systems in disease pathogenesis: functional interactions in cytokine regulation, cellular differentiation and tissue homeostasis

Trifunovic, Aleksandra - C 15

Institute for Mitochondrial Diseases and Ageing
Manipulation of CLPP protease to complement mitochondrial respiratory deficiency

Wirth, Brunhilde - C 16

Institute for Human Genetics
Unraveling the molecular and cellular mechanism underlying spinal muscular atrophy of genetic modifiers