Benzing, Thomas - B 3

Dynamic roles of podocytes in glomerular filtration and the progression of chronic kidney disease

Bartram MP, Dafinger C, Habbig S, Benzing T, Schermer B, and Muller RU (2015). Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation. BMC Nephrol 16, 55.

Benzing T (2015). Polycystic kidney disease. HALTing PKD progression--revival of blood pressure control. Nat Rev Nephrol 11, 129-131.

Brahler S, Ising C, Barrera Aranda B, Hohne M, Schermer B, Benzing T, and Brinkkoetter PT (2015). The NF-kB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-kB. Am J Physiol Renal Physiol 309, F617-626.

Grahammer F, Benzing T, and Huber TB (2015). New insights into mechanisms of glomerular injury and repair from the 10th international podocyte conference 2014. Kidney Int 87, 885-893.

Hagmann H, Taniguchi Y, Pippin JW, Kauerz HM, Benzing T, Shankland SJ, and Brinkkoetter PT (2015). Cyclin I and p35 determine the subcellular distribution of Cdk5. Am J Physiol Cell Physiol 308, C339-347.

Ising C, Koehler S, Brahler S, Merkwirth C, Hohne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Bruning JC, Kurschat CE, Muller RU, Wiesner RJ, Langer T, Benzing T, and Brinkkoetter PT (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med 7, 275-287.

Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, and Kreidberg JA (2015). WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development 142, 1254-1266.

Kann M, Ettou S, Jung YL, Lenz MO, Taglienti ME, Park PJ, Schermer B, Benzing T, and Kreidberg JA (2015). Genome-wide analysis of Wilms' tumor 1-controlled gene expression in podocytes reveals key regulatory mechanisms. J Am Soc Nephrol 26, 2097-2104.

Rinschen MM, Pahmeyer C, Pisitkun T, Schnell N, Wu X, Maass M, Bartram MP, Lamkemeyer T, Schermer B, Benzing T, and Brinkkoetter PT (2015). Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture. Proteomics 15, 1326-1331.

Rinschen MM, Benzing T, Limbutara K, and Pisitkun T (2015). Proteomic analysis of the kidney filtration barrier - problems and perspectives. Proteomics Clin Appl 9,1053-1068.

Seeger-Nukpezah T, Geynisman DM, Nikonova AS, Benzing T, and Golemis EA (2015). The hallmarks of cancer: Relevance to the pathogenesis of polycystic kidney disease. Nat Rev Nephrol 11, 515-534.

Selected publications 2014

Benzing T (2014). Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol. DOI: 10.1681/ASN.2013070760.

Benzing T (2014). Polycystic kidney disease: Halting pkd progression-revival of blood pressure control. Nat Rev Nephrol. DOI: 10.1038/nrneph.2014.241.

Borgal L, Rinschen MM, Dafinger C, Hoff S, Reinert MJ, Lamkemeyer T, Lienkamp SS, Benzing T, and Schermer B (2014). Casein kinase 1 alpha phosphorylates the wnt regulator jade-1 and modulates its activity. J Biol Chem 289, 26344-26356.

Gravemann S, Brinkkoetter PT, Vehreschild JJ, Franke B, Ehren K, Bunemann E, Orbach H, Wei V, Hellmich M, Benzing T, and Fatkenheuer G (2014). Low-grade proteinuria is highly prevalent in hiv-positive patients on antiretroviral treatment. AIDS 10.1097/QAD.0000000000000324.

Hagmann H, Bossung V, Belaidi AA, Fridman A, Karumanchi SA, Thadhani R, Schermer B, Mallmann P, Schwarz G, Benzing T, and Brinkkoetter PT (2014). Low-molecular weight heparin increases circulating sflt-1 levels and enhances urinary elimination. PLoS One 9, e85258.

Hagmann H, Kuczkowski A, Ruehl M, Lamkemeyer T, Brodesser S, Horke S, Dryer S, Schermer B, Benzing T, and Brinkkoetter PT (2014). Breaking the chain at the membrane: Paraoxonase 2 counteracts lipid peroxidation at the plasma membrane. FASEB J 28, 1769-1779.

Hagmann H, Taniguchi Y, Pippin JW, Kauerz HM, Benzing T, Shankland SJ, and Brinkkoetter PT (2014). Cyclin i and p35 determine the subcellular distribution of cdk5. Am J Physiol Cell Physiol. DOI:10.1152/ajpcell.00168.2014.

Kohli P, Bartram MP, Habbig S, Pahmeyer C, Lamkemeyer T, Benzing T, Schermer B, and Rinschen MM (2014). Label-free quantitative proteomic analysis of the yap/taz interactome. Am J Physiol Cell Physiol 306, C805-818.

Kurschat CE, Muller RU, Franke M, Maintz D, Schermer B, and Benzing T (2014). An approach to cystic kidney diseases: The clinician's view. Nature reviews Nephrology 10, 687-699.

Mueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Muller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, and Schumacher B (2014). Daf-16/foxo and egl-27/gata promote developmental growth in response to persistent somatic DNA damage. Nature cell biology 16, 1168-1179.

Rinschen MM, Pahmeyer C, Pisitkun T, Schnell N, Wu X, Maass M, Bartram MP, Lamkemeyer T, Schermer B, Benzing T, and Brinkkoetter PT (2014). Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin c-terminal phosphorylation as a determinant of slit diaphragm complex architecture. Proteomics 10.1002/pmic.201400235.

Rinschen MM, Schermer B, and Benzing T (2014). Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: From bench to bedside and back again. J Am Soc Nephrol 25, 1140-1147.

Rinschen MM, Wu X, Konig T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, and Schurek EM, Volker LA, Tax J, Lamkemeyer T, Rinschen MM, Ungrue D, Kratz JE, 3rd, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, and Hohne M (2014). A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (phb) domain protein podocin. J Biol Chem 289, 11262-11271.

Rinschen MM, Wu X, Konig T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, and Benzing T (2014). Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol ASN.2013070760 [pii] 10.1681/ASN.2013070760.

Schurek EM, Volker LA, Tax J, Lamkemeyer T, Rinschen MM, Ungrue D, Kratz JE, 3rd, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, and Hohne M (2014). A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (phb) domain protein podocin. J Biol Chem 289, 11262-11271.

Trachtman H, Benzing T, Sever S, Harris RC, and Reiser J (2014). The grand challenge of nephrology. Frontiers in medicine 1, 28.

Former Funding Period 01/2014 - 12/2016

Information from this funding period will not be updated anymore. New research related information is available here.


Prof. Dr. med. Thomas Benzing

Chair CMMC

Prof. Dr. med. Thomas Benzing

Dept. II of Internal Medicine
Principal Investigator C 2

cmmc-office@uni-koeln.de

Work +49 221 478 89536

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50931 Cologne

https://cmmc.uni-koeln.de

Publications

Link to PubMed