Overview of ongoing dissertations

Acharya, Aviseka (M.Sc in Pharmakology)
Topic: The importance of gravity for the differentiation potential of pluripotent stem cells to various organ-specific cells
Supervisor: Prof. Dr. A. Sachinidis - Inst. for Neurophysiology

Adamo, Christin (M.Sc. in Biomedical Sciences)
Topic: New mechanisms of fibrillin dependent fibrosis
Supervisor: PD Dr. G. Sengle - Inst. for Biochemistry II

Adler, Stephanie (M.Sc. in Medical Engineering Science)
Topic:Elaboration of functional cell-cell adhesion networks in the C. elegans intestine
Supervisor: Prof. Dr. O. Bossinger - Inst. of Molecular Cell Biology (Anatomy I)

Al-Qadhi, Safwan (Dipl.-Ing.)
Topic: Realizing a demand controlled application of deep brain stimulation with the portable neurostimulator
Supervisor: Prof. Dr. C. Hauptmann - Research Center Jülich 

Al-Sawaf, Othman (Dr.med.)
Topic: Genomic aberrations in AKT-C driven Richter's transformation
Supervisor: Dr. Ch. Pallasch - Dept. I of Internal Medicine

Alawbathani, Salem (M.Sc.)
Topic: Identification and functional characterization of genes involved in microcephaly families from Yeme
Supervisor: Prof. Dr. A. Noegel - Inst. for Biochemistry I;

Ayachi, Ouissam (M.Sc. in Biomedical Sciences)
Topic: The role of dysregulated mitochondrial apoptotoc pathways as the basic prerequisite for the autonomic growth and metastatic progression of melanoma cells
Supervisor: Prof. Dr. C. Mauch - Dept. of Dermatology

Batool, Mehreen(M.Sc.)
Topic: Role of the 6-transmembrane protein Stamp2 in Pulmonary Hypertension
Supervisor: Prof. PD Dr. S. Rosenkranz - Dept. III of Internal Medicine

Behfar, Qumars (MBBS)
Topic: Effects of cognitive stimulation on cerebral perfusion, functional and structural connectivity and grey
matter volume in patients with mild to moderate Alzheimer´s disease
Supervisor: PD Dr. Ö.A. Onur - Clinic and Polyclinic of Neurology

Bayer, Robin (M.Sc. in Biomedical Engineering)
Topic: Development of a 3D cell co-culture model to evaluate the biomechanical effect of hypertensive
regulating agents
Supervisor: Prof. Dr. Dr. J. Hescheler - Inst. for Bioengineering

Borde, Julika (M.Sc in Biological Sciences)
Topic: Prospective validation of the polygenic risk score (PRS) for cancer risk stratification and
characterization of three candidate breast cancer susceptibility genes
Supervisor: PD Dr. E Hahnen - Center Familial Breast-and Ovarian Cancer

Böll, Boris (Dr. med.)
Topic: Expression regulatorischer Oberflächen-moleküle von NK-Zellen sowie die Bestimmung des cytotoxischen Potentials und die Zytokinsekretion nach Inhibition oder Aktivierung des CD30 Signalwegs
Supervisor: Prof. Dr. A. Engert - Dept. I for Internal Medicine

Buhlmann, Julia (Dipl. Biol.)
Topic: Estimation and optimization of the simulation effects of deep brain stimulation under consideration of the electrode
Supervisor: Prof. Dr. C. Hauptmann - Research Center Jülich

Bukowiecki, Anne (M.Sc. in Biology)
Topic: Myeloid cell function in corneal hem- and lymphangiogenesis
Supervisor: Prof. Dr. S. Eming - Dept. of Dermatology

Chatzigiakos, Antonis (Dipl.-Vet. Med.)
Topic: The role of macrophage death in atherosclerosis
Supervisor: Prof. Dr. M. Pasparakis - Inst. for Genetics

Daimagüler, Hülya-Sevcan (M.Sc in Biotechnology)
Topic: Deciphering the dystroglycan processing pathway by the identification of disease genes for muscular dystrophy
Supervisor: Dr. S. Cirak - CMMC

Dannhausen, Katharina (M.Sc.)
Topic: Retinal degeneration and microglial activation in juvenile Neuronal CeroidLipofuscinosis
Supervisor: Prof. Dr. Th. Langmann - Dept. of Experimental Immunology of the Eye

de Castro Kroner, Juliana (M.Sc. in Biological Sciences)
Topic: Corticoid modulation of acquired immunity against intracellular pathogens
Supervisor: Prof. Dr. M. Fabri - Dept. of Dermatology

Delle Vedove, Andrea (M.Sc. in Medicine)
Topic: Identification and functional assessment of novel neuromuscular disease-causing genes
Supervisor: Prof. Dr. B. Wirth - Inst. for Human Genetics

Dennin, Adele (Dr. med.)
Topic: Activity and survival of dopamine neurons derived from embryonic stem cells
Supervisor: Prof. Dr. A. Jacobs - Europ. Inst. for Molecular Imaging
Technologiehof Münster

Dharmesh, Hirani (M.Sc. In Biology)
Topic: Functional role of KLF4 in hyperoxia-induced neonatal chronic lung diseas
Supervisor: Prof. Dr. Dr. M. A. A. Alcazar - Translational Experimental Pediatrics

Dinger, Katharina (Dipl.-Vet. Med.)
Topic: Metabolic programming of lung disease
Supervisor: Prof. Dr. J. Dötsch - Dept. of Pediatrics and Adolescent Medicine

Dixit, Vishal (M.Sc. in Molecular Biology and Biotechnology)
Topic: Understanding the role of long non-coding RNAs in zebrafish cardic regeneration
Supervisor: Dr. Leo Kurian - Lab for Developmental and Regenerative RNA biology

El-Awaad, Ehab (M.Sc.)
Topic: Targeting of the thrombospondin-a2d-1 interaction – Discovery of activators of synaptogenesis and development of analgesics against neuropathic pain
Supervisor: Prof. Dr. S. Herzig - Inst. of Pharmacology

Gharbi, Hakam (M.Sc. in Biology)
Topic: Characterization of genes involved in the development of age-related kidney disease and renal cancer and their role in the regulation of lifespan in C.elegans
Supervisor: Prof. Dr. T. Benzing - Dept. II of Internal Medicine and CMMC

Gladiola, Goranci-Buzhala (M.Sc. in Biology)
Topic: Cilia induction by abrogating Nek-2 function to inhibit proliferation and induce differentiation of GBM cells
Supervisor: Dr. J. Gopalakrishnan - CMMC

Hassenrück, Floyd (M.Sc. in Biomedical Sciences)
Topic: Mechanisms of kinase inhibitors targeting B cell receptor signalling and of acquired resistance in B cell malignancies
Supervisor: Dr. G. Krause - Dept. I of Internal Medicine

Hauser, Christoph (Phar., State Examination)
Topic: in-vitro pharmacological characterization of potential radio tracers for human transglutaminase 2 imaging
Supervisor: Prof. Dr. S. Herzig - Inst. of Pharmacology

Hos, Nina (Dr. med.)
Topic: Type l interferon regulated phagosome/autophagosome biogenesis in macrophages upon Salmonella enteicaserovarTyphimurium infection
Supervisor: Dr. N. Robinson - Inst. for Medical Microbiology, Immunology and Hygiene / CECAD

Hou, Yanhong (M.Sc in Ophthalmology)
Topic: Photodynamic therapy of pathologic corneal hem- and lymphangiogenesis in ocular surface diseases
Supervisor: Prof. Dr. C. Cursiefen - Dept. of Ophthalmology

Hönig, Merle (M.Sc in Neurophychology)
Topic: Influences of Epigenetic Mechanisms and Cognitive Reserve on Altzheimer's Disease: A Multimodal Imaging Approach
Supervisor: Prof. Dr. A. Drzezga - Clinic and Polyclinic for Nuclear Medicine

Hsin, Chih-Hsuan (M.Sc. in FOKUS Pharmazie )
Topic: Establishment of phenotyping metrics of key human drug transporters in vitro and in vivo
Supervisor: Prof. Dr. U. Fuhr - Dept. of Pharmacology I&II

Jiang, Qu (M.Sc in Medicine)
Topic: The role of the lysine-specific histone demethylases KDM1A in the pathogenesis of lymphatic leukemias
Supervisor: Dr. M. Herling - Clinic I of Internal Medicine

Khayyat, Awa (M.Sc. in Biochemistry)
Topic: Identification and functional characterization of genes involved in non-syndromic autosomal recessive primary microcephaly
Supervisor: Prof. Dr. A.A. Noegel - Inst. of Biochemistry I

Kimoloi, Sammy (M.Sc. in Clinical Pharmacology)
Topic: Effects of mitochondrial DNA deletions on skeletal muscle function and regenerative capacity in mtDNAdeletor mouse models
Supervisor: Prof. Dr. R. Wiesner - Inst. for Vegetative Physiology

Klaschik, Kristina (M. Sc. in Biological Sciences)
Topic: The role of GPRC5A in familial breast cancer
Supervisor: PD Dr. E. Hahnen - Center for Familial Breast and Ovarian Cancer

Klein, Ines (M.Sc in Clinic and Experimental Neurosciences)
Topic: Modulation of tissue specific membrane transporters for prevention of chemotherapy-induced peripheral neuropathy
Supervisor: PD Dr. Helmar Lehmann - Inst. for Neurology

Klug-Micu, Georgiana Maria (Dipl. Chem.)
Topic: Vitamin D-dependent innate immune pathways in dendritic cells
Supervisor: Prof. Dr. M. Fabri - Dept. of Dermatology

Kretschmer, Tobias (M.Sc. in Biomedical Science)
Topic: Disruption of the placental feto-maternal transfer zone via maternal obesity
Supervisor: Prof. Dr. J. Dötsch - Clinic and Polyclinic for Paediatric and Adolescent Medicine

Kulkarni, Pranav (M.Sc.)
Topic: Integrating copy number variation and allele-specific expression from tumor exome and transcriptome data
Supervisor: Prof. Dr. A. Beyer - CECAD

Le, Viet Nhat Hung (Resident in Ophthalmology)
Topic: Fine needle-diathermy regresses pathological corneal (lymph)angiogenesis and promotes high risk
corneal graft survival
Supervisor: Prof. Dr. C. Cursiefen - Dept. of Ophthalmology

Lepperhof, Vera (Dipl.-Biol.)
Topic: Co-transplantation and in vivo analysis of ES cell or iPS cell derived cardiomyocytes and mesenchymal stem cells for cardiac regeneration
Supervisor: PD Dr. Dr. T. Šaric - Inst. for Neurophysiology

Lindner, Angie (M.Sc.)
Topic: Genetic and functional analysis of Multiple Symmetric Lipomatosis (MSL)
Supervisor: Prof. Dr. Ch. Netzer - Inst. for Human Genetics

Meyer, Anja (M.Sc. in Biology)
Topic: Role of Prostaglandin E2 receptor signaling for the regulation of Th17 cells in chronic inflammation
Supervisor: PD Dr. D. Kofler - Dept. of Internal Medicine

Mohr, Jasmine (M.Sc. in Human- and Molecular Biology)
Topic: The functional role of Krüppel-like-factor 4 in normal and aberrant alveolarization
Supervisor: Prof. Dr. Dr. M. A. A. Alcazar - Clinic and Polyclinic for Paediatric and Adolescent Medicine

Nagy, Viktória (Dipl. Biol.)
Topic: The mechanism of ?-cytokines and CD28 costimulation to counteract TGF-ß1 and IL-10 mediated T cell repression
Supervisor: Prof. Dr. H. Abken - Dept. I of Internal Medicine and CMMC

Nemade, Harshal (M.Sc.)
Topic: Effects of Etoposide on the iPSCs-derived cardiomyocytes
Supervisor: Prof. Dr. A. Sachinidis - Inst. for Neurophysiology

Oberbeck, Sebastian (M.Sc. Biomedical Sciences)
Topic: Do TCL1 and T-cell receptor signaling cooperate towards T-PLL?
Supervisor: Dr. M. Herling - Dept. I of Internal Medicine

Philipp, Denise (M.Sc. in Biology)
Topic: Elucidating the role of inflammation in cardiac hypertrophy
Supervisor: Prof. Dr. Y.-H. Choi - Dept. of Cardiothoracic Surgery

Poll-Wolbeck, Simon (M.Sc. in Biology)
Topic: The role of LEF1 and the biological mechanisms of nitric oxide acetylsali-cylic acid treatment in chronic lymphocytic leukemia
Supervisor: Prof. Dr. K.-A. Kreuzer - Dept. I of Intneral Medicine

Probst, Kristina (M.Sc.)
Topic: Analyze the role of mitochondria for cartilage degeneration
Supervisor: Prof. Dr. B. Brachvogel - Dept. For Pedriatics

Ramani, Anand (M.Sc. in Medical Pharmacology)
Topic: Mechanisms and regulation of Sas-4 mediated functional centrosome assembly
Supervisor: Dr. J. Gopalakrishnan - CMMC

Rashid, Khalid (M.Sc. in Biochemistry)
Topic: Microglia-specific expression of Translocator Protein (18kDa) ( TSPO) and its therapeutic role in retinal degeneration
Supervisor: Prof. Dr. Th. Langmann - Dept. of Experimental Immunology of the Eye

Refaian, Nasrin (M.Sc. in Biology )
Topic: Impact of Melanoma cells and Fibroblasts on Tumor-associated Lymphangiogenesis
Supervisor: Prof. Dr. L. Heindl - Dept. of Ophthalmology

Rehorst, Wiebke (M.Sc. in Biological Sciences)
Topic: Characterization of Intercellular Communication Mechanisms at the Neuromuscular Junction in Spinal Muscular Atrophy
Supervisor: Dr. M. J. Kye - Inst. for Human Genetics

Samak, Mostafa (M.Sc. in Molecular Medicine)
Topic: Elucidating the role of inflammation in cardiac  hypertrophy
Supervisor: Prof. Dr. Th. Wahlers - Dept. of Cardiac and Thoracic Surgery

Schmalz, Julia (M.Sc.)
Topic: Generation of adeno-associated viral (AAV) vector-based vaccines for suppression of breast cancer angiogenesis and metastasis
Supervisor: Prof. Dr. H. Büning - Hannover Medical School, Dept. I of Internal Medicine and CMMC

Schmitt, Anna (M.Sc. in Medical Biology)
Topic: Role of ATM in chemotherapy resistance and tumor-microenvironment
Supervisor: Prof. Dr. Ch. Reinhardt - Dept. I of Internal Medicine

Schommers, Philipp
Topic: Immune response to HIV-1 in elite controllers and elite neutralizers
Supervisor: Prof. Dr. F. Klein - Inst. for Virology

Sommer, Andrea (Dipl. Engineer for Biological Chemistry)
Topic: Vitamin D regulation of the T cell mediated host response
Supervisor: Prof. Dr. M. Fabri - Dept. of Dermatology

Spanou, Charikleia (M.Sc. in Molecular Biology and Biomedicine)
Topic: Regulation of growth factors by fibrillin microfibrils in connective tissue disorders
Supervisor: PD Dr. G. Sengle - Inst. for Biochemistry II

Steinbach, Anne (Dipl. Biol.)
Topic: Identification of epigenetic causes of prostate cancer development and therapy resistance in lung
Supervisor: Prof. Dr. Dr. M.-R. Schweiger - Functional Epigenomics CCG

Taiwo, Moyinoluwa (M.Sc. in Pharmacology and Biotechnology)
Topic: The PDGF/PDGF- Receptor System in the Murine Laser Damage model of Neovascular
Age-related Macular Degeneration (NAMD): Role of Retinal Immune Cells
Supervisor: Prof. Dr. Th. Langmann - Dept. of Ophthalmology

Telugu, Narasimha Swamy (M.Sc. in Animal Biotechnology)
Topic: Elucidation of the pathophysiological mechanism of arrhythmogenic right ventricular cardiomyopathy (ARVC) caused by a point mutation in transmembrane protein 43 gene (TMEM43) by using human in vitro iPS cell-based and genetically engineered mouse disease models
Supervisor: PD Dr. Dr. T. Šaric - Inst. for Neurophysiology

Thomas, Anne (Dr. med.)
Topic: Interaktion von amyloid precursor Protein (APP) u. presenilin 1 (PS1) bei Demenz vom Alzheimer-Typ (AD)
Supervisor: Prof. Dr. A. Jacobs - Europ. Inst. for Molecular Imaging

Thomalla, Daniel (M.Sc. in Biological Sciences)
Topic: Identification of mechanisms of acquired resistance towards BCL-2 inhibitors and strategies to
overcome this resistance in B cell lymphoma
Supervisor: Dr. L. Frenzel - CECAD

Timper, Katharina (Dr. med.)
Topic: Circuit mapping of GLP-1-Receptor expressing neurons in the brain - impact on whole body metabolism, glucose homeostasis and reward system
Supervisor: Prof. Dr. J. Brüning - MPI for Metabolism Research

von Jan, Jana (Pharmacist)
Topic: Novel targeted treatment approaches for T-PLL
Supervisor: Dr. M. Herling - Dept. I of Internal Medicine

von Tresckow, Bastian (Dr. med.)
Topic: Bedeutung des membranproteins CD30 – Untersuchung der Zusammen-hänge zwischen cholesterin-abhängigem shedding von CD30 u. der zellulären Immunregula-tion
Supervisor: Prof. Dr. A. Engert - Dept. I of Internal Medicine

Wagener, Svenja (M.Sc. in Molecular Biomedicine)
Topic: HR23b expression is a potential predictive biomarker for the sensitivity to HDAC inhibitor treatment: in vitro and in vivo studies in mesenchymal tumours
Supervisor: PD Dr. S. Merkelbach-Bruse - Institute for Pathology

Wang, Lingyu (Dr. med.)
Topic: The Epigeneitic Crosstalk Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
Supervisor: Prof. Dr. M. Odenthal - Inst. for Pathology

Weber-Lassalle, Nana-Maureen (M. Sc. in Biological Sciences)
Identification and characterisation of novel breast and/or ovarian cancer susceptibility genes by
using massively parallel DNA sequencing
Supervisor: Prof. Dr. E. Hahnen - Center of Familial Breast and Ovarian Cancer

Wieters, Frederique (M.Sc. in Molecular Cell Biology)
Topic: Neural circuits of Spasticity after experimental stroke
Supervisor: Dr. M. Aswendt - Center for Neurology and Psychiatry

Yang, Tsun-Po (M.Sc. in Computer Science)
Topic: Mechanism, structure and history of somatic rearrangements in cancer
Supervisor: Dr. M. Peifer - CMMC