Overview of ongoing dissertations

 

Al-Qadhi, Safwan (Dipl.-Ing.)
Topic: Realizing a demand controlled application of deep brain stimulation with the portable neurostimulatorSupervisor: Prof. Dr. C. Hauptmann - Research Center Jülich 

Alawbathani, Salem (M.Sc.)
Topic: Identification and functional characterization of genes involved in microcephaly families from Yeme
Supervisor: Prof. Dr. A. Noegel - Inst. for Biochemistry I 

Batool, Mehreen (M.Sc.)
Topic: Role of the 6-transmembrane protein Stamp2 in Pulmonary Hypertension
Supervisor: Prof. Dr. S. Rosenkranz - Dept. III of Internal Medicine

Baudis, Birte (Dipl. Biol.)
Topic: Functional and immunological properties of cardiac myocytes derived from pluripotent germ line stem cells
Supervisor: Dr. T. Šaric  - Inst. for Neurophysiology

Buhlmann, Julia (Dipl. Biol.)
Topic: Estimation and optimization of the simulation effects of deep brain stimulation under consideration of the electrode
Supervisor: Prof. Dr. C. Hauptmann - Research Center Jülich

Bukowiecki, Anne (M.Sc.)
Topic: Myeloid cell function in corneal hem- and lymphangiogenesis
Supervisor: Prof. Dr. S. Eming - Dept. of Dermatology

Chatzigiakos, Antonis (Dipl.-Vet. Med.)
Topic: The role of macrophage death in atherosclerosis
Supervisor: Prof. Dr. M. Pasparakis - Inst. for Genetics

Dannhausen, Katharina (M.Sc.)
Topic: Retinal degeneration and microglial activation in juvenile Neuronal CeroidLipofuscinosis
Supervisor: Prof. Dr. Th. Langmann - Dept. of Experimental Immunology of the Eye

Dalvi, Priya (M.Sc.)
Topic: Deciphering the oncogenic potential of lysine specific demethylase (LSD1)
Supervisor: PD. Dr. M. Odenthal - Inst. for Pathology

de Castro Kroner, Juliana (M.Sc.)
Topic: Corticoid modulation of acquired immunity against intracellular pathogens
Supervisor: PD Dr. M. Fabri - Dept. of Dermatology

Delle Vedove, Andrea (M.Sc.)
Topic: Identification and functional assessment of novel neuromuscular disease-causing genes
Supervisor: Prof. Dr. B. Wirth - Inst. for Human Genetics

Dinger, Katharina (Vet. Med.)
Topic: Metabolic programming of lung disease
Supervisor: Prof. Dr. J. Dötsch - Dept. of Pediatrics and Adolescent Medicine

Dixit, Vishal (M.Sc.)
Topic: Understanding the role of long non-coding RNAs in zebrafish cardic regeneration
Supervisor: Dr. Leo Kurian - Lab for Developmental and Regenerative RNA biology

El-Awaad, Ehab (M.Sc.)
Topic: Targeting of the thrombospondin-a2d-1 interaction – Discovery of activators of synaptogenesis and development of analgesics against neuropathic pain
Supervisor: Prof. Dr. S. Herzig - Inst. of Pharmacology

Gharbi, Hakam (M.Sc.)
Topic: Characterization of genes involved in the development of age-related kidney disease and renal cancer and their role in the regulation of lifespan in C.elegans
Supervisor: Prof. Dr. T. Benzing - Dept. II of Internal Medicine and CMMC

Gooi, Li Ming (M.Sc.)
Topic: Centrosome functions in stem cell homeostasis during ageing
Supervisor: Dr. J. Gopalakrishnan - CMMC

Goranci-Buzhala, Gladiola (M.Sc.)
Topic: Cilia induction by abrogating Nek-2 function to inhibit proliferation and induce differentiation of GBM cells
Supervisor: Dr. J. Gopalakrishnan - CMMC

Hauser, Christoph (Phar., State Examination)
Topic: in-vitro pharmacological characterization of potential radio tracers for human transglutaminase 2 imaging
Supervisor: Prof. Dr. S. Herzig - Inst. of Pharmacology

Hos, Nina (Dr. med.)
Topic: Type l interferon regulated phagosome/autophagosome biogenesis in macrophages upon Salmonella enteicaserovarTyphimurium infection
Supervisor: Dr. N. Robinson - Inst. for Medical Microbiology, Immunology and Hygiene / CECAD

Hou, Yanhong
Topic: Photodynamic therapy of pathologic corneal hem- and lymphangiogenesis in ocular surface diseases
Supervisor: https://augenklinik.uk-koeln.de/forschung/arbeitsgruppen-labore/ag-ophthalmo-onkologie/Prof. Dr. Claus Cursiefen - Dept. of Ophthalmology

Hsin, Chih-Hsuan (M.Sc.)
Topic: Establishment of phenotyping metrics of key human drug transporters in vitro and in vivo
Supervisor: Prof. Dr. U. Fuhr - Dept. of Pharmacology I&II

Huber, Anke (Dipl.-Biol.)
Topic: Targeted integration of viral vector genomes by exploiting the AAV Rep system
Supervisor: Prof. Dr. H. Büning - Hannover Medical School, Dept. I of Internal Medicine and CMMC

Imhof, Thomas (Dr. med. dent.)
Topic: The function of Tenascin N in craniofacial development and disease
Supervisor: Prof. Dr. M. Koch - Inst. for Oral and Musculoskeletal Biology, Dental School /Inst. for Biochemistry II

Khayyat, Awa (M.Sc.)
Topic: Identification and functional characterization of genes involved in non-syndromic autosomal
recessive primary microcephaly
Supervisor: Dr. Jay Gopalakrishnan - Center for Molecular Medicine Cologne

Kimoloi, Sammy (M.Sc.)
Topic: Effects of mitochondrial DNA deletions on skeletal muscle function and regenerative capacity in mtDNAdeletor mouse models
Supervisor: Prof. Dr. R. Wiesner - Inst. for Vegetative Physiology

Klaschik, Kristina (M. Sc.)
Topic: The role of GPRC5A in familial breast cancer
Supervisor: PD Dr. E. Hahnen - Center for Familial Breast and Ovarian Cancer

Klug-Micu, Georgiana Maria (Dipl. Chem.)
Topic: Vitamin D-dependent innate immune pathways in dendritic cells
Supervisor: PD Dr. M. Fabri - Dept. of Dermatology

Krämer, Andrea (M.Sc.)
Topic: Functional characterization of somatic mutations in neuroblastoma
Supervisor: Prof. Dr. M. Fischer - Dept. of Pediatric Oncology and Hematology

Kulkarni, Pranav (M.Sc.)
Topic: Integrating copy number variation and allele-specific expression from tumor exome and transcriptome data
Supervisor: Prof. Dr. A. Beyer - CACAD

Lepperhof, Vera (Dipl.-Biol.)
Topic: Co-transplantation and in vivo analysis of ES cell or iPS cell derived cardiomyocytes and mesenchymal stem cells for cardiac regeneration
Supervisor: PD Dr. T. Šaric - Inst. for Neurophysiology

Lindner, Angie (M.Sc.)
Topic: Genetic and functional analysis of Multiple Symmetric Lipomatosis (MSL)
Supervisor: Prof. Dr. Ch. Netzer - Inst. for Human Genetics

Macheleidt, Iris Felicitas (M.Sc.)
Topic: Protein- and Gen Expression Regulation of and by the Histone Demethylase LSD1 in Lung Cancer
Supervisor: PD Dr. M. Odenthal - Inst. for Pathology

Meumann, Nadja (M.Sc.)
Topic: Induction of a specific immune response and inhibition of tumor angiogenesis in HCC bytumor-associated-antigen-conditioneddecentric cells and adeno-associated virus vectors
Supervisor: Prof. Dr. H. Büning - Hannover Medical School, Dept. I of Internal Medicine and CMMC

Mikhael, Nelly (M.Sc.)
Topic: Controlled in-situ expansion of ransplanted cardiomyocytes from pluripotent stem cells by induction of expression of Yes- Asscociated Protein 1 (Yap1)
Supervisor: Dr. Kurt Pfannkuche - Inst. for Neurophysiology

Moosa, Shahida (MBBCh)
Topic: Molecular pathogenesis of inherited disorders of bone: osteogenesis Imperfecta and beyond
Supervisor: Prof. Dr. B. Wollnik - Inst. for Human Genetics

Nagy, Viktória (Dipl. Biol.)
Topic: The mechanism of ?-cytokines and CD28 costimulation to counteract TGF-ß1 and IL-10 mediated T cell repression
Supervisor: Prof. Dr. H. Abken - Dept. I of Internal Medicine and CMMC

Nemade, Harshal (M.Sc.)
Topic: Effects of Etoposide on the iPSCs-derived cardiomyocytes
Supervisor: Prof. Dr. A. Sachinidis - Inst. for Neurophysiology

Oberbeck, Sebastian (M.Sc.)
Topic: Do TCL1 and T-cell receptor signaling cooperate towards T-PLL?
Supervisor: Dr. M. Herling - Dept. I of Internal Medicine

Philipp Denise
Topic: Elucidating the role of inflammation in cardiac hypertrophy
Supervisor: Prof. Dr. Yeong-Hoon Choi - Dept. of Cardiothoracic Surgery

Probst, Kristina (M.Sc.)
Topic: Analyze the role of mitochondria for cartilage degenerationSupervisor: Prof. Dr. B. Brachvogel - Dept. of Ophthalmology

Ramani, Anand (M.Sc.)
Topic: Mechanisms and regulation of Sas-4 mediated functional centrosome assembly
Supervisor: Dr. J. Gopalakrishnan - CMMC

Rashid, Khalid (M.Sc.)
Topic: Microglia-specific expression of Translocator Protein (18kDa) ( TSPO) and its therapeutic role in retinal degeneration
Supervisor: Prof. Dr. Th. Langmann - Dept. of Experimental Immunology of the Eye

Refaian, Nasrin (M.Sc.)
Topic: Impact of Melanoma cells and Fibroblasts on Tumor-associated Lymphangiogenesis
Supervisor: Prof. Dr. L. Heindl - Dept. of Ophthalmology

Rehorst, Wiebke (M.Sc.)
Topic: Characterization of Intercellular Communication Mechanisms at the Neuromuscular Junction in Spinal Muscular Atrophy
Supervisor: Dr. M. J. Kye - Inst. for Human Genetics

Schmalz, Julia (M.Sc.)
Topic: Generation of adeno-associated viral (AAV) vector-based vaccines for suppression of breast cancer angiogenesis and metastasis
Supervisor: Prof. Dr. H. Büning - Hannover Medical School, Dept. I of Internal Medicine and CMMC

Schmitt, Anna (M.Sc.)
Topic: Role of ATM in chemotherapy resistance and tumor-microenvironment
Supervisor: Prof. Dr. Ch. Reinhardt - Dept. I of Int. Medicine

Schommers, Philipp
Topic: Immune response to HIV-1 in elite controllers and elite neutralizers
Supervisor: Prof. Dr. F. Klein - Institute for Virology

Shahriyari, Mina (M.Sc.)
Topic: Electrophysiological integration and action potential properties of transplanted in vitro grown
Supervisor: PD Dr. M. Halbach - Dept. III of Internal Medicine

Steinbach, Anne (Dipl. Biol.)
Topic: Identification of epigenetic causes of prostate cancer development and therapy resistance in lung
Supervisor: Prof. Dr. Dr. M.-R. Schweiger - Functional Epigenomics CCG

Telugu, Narasimha Swamy (M.Sc.)
Topic: Elucidation of the pathophysiological mechanism of arrhythmogenic right ventricular cardiomyopathy (ARVC) caused by a point mutation in transmembrane protein 43 gene (TMEM43) by using human in vitro iPS cell-based and genetically engineered mouse disease models
Supervisor: PD Dr. T. Šaric - Inst. for Neurophysiology

Timper, Katharina (Dr. med.)
Topic: Circuit mapping of GLP-1-Receptor expressing neurons in the brain - impact on whole body metabolism, glucose homeostasis and reward system
Supervisor: Prof. Dr. J. Brüning - MPI for Metabolism Research

Vondey, Verena (M.Sc.)
Topic: Functional role of the receptor tyrosine kinase Axl in thge panthogenesis of B cell malignancies
Supervisor: Prof. Dr. G. Krause - Dept. I of Internal Medicine

Wagener, Svenja (M.Sc.)
Topic: Functional role of the receptor tyrosine kinase Axl in thge panthogenesis of B cell malignancies
Supervisor: PD Dr. Sabine Merkelbach-Bruse - Institute for Pathology

Wang, Lingyu (Dr. med.)
Topic: The Epigeneitic Crosstalk Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
Supervisor: PD Dr. M. Odenthal - Inst. for Pathology

Weber-Lassalle, Nana-Maureen (M. Sc.)
Identification and characterisation of novel breast and/or ovarian cancer susceptibility genes by
using massively parallel DNA sequencing
Supervisor: Prof. Dr. Eric Hahnen - Center of Familial Breast and Ovarian Cancer

Yu, Xiaojie (M.Sc.)
Topic: Characterization of microRNA as tumor suppressor in hepatocellular carcinoma
Supervisor: PD Dr. M. Odenthal - Inst. for Pathology

Zare Mehrjardi, Nagres (M.Sc.)
Topic: Lineage selection and characterization of human induced pluripotent stem (iPS) cell-derived neural progenitor cells and their utility for treatment of traumatic brain injuries in rats
Supervisor: PD Dr. T. Šaric - Inst. for Neurophysiology