Overview of completed dissertations

Huber, Anke (Dipl.-Biol.)
Topic: Novel universal targeting platform to improve AAV's use in gene therapy
Supervisor: Prof. Dr. H. Büning - Hannover Medical School, previous: Dept. I of Internal Medicine and CMMC

Thomas Imhof (M. Sc. in Life Sciences, Dr. med. dent.)
Topic: Einfluss von Tenascin-N auf die Regulation und Differenzierung von mesenchymalen Stammzellen in vivo
Supervisor: Prof. Dr. Manuel Koch – Institute for Oral and Musculoskeletal Biology

Meumann, Nadja
(M.Sc.)Topic: Induction of a specific immune response and inhibition of tumor angiogenesis in HCC bytumor-associated-antigen-conditioneddecentric cells and adeno-associated virus vectors
Supervisor: Prof. Dr. Hildegard Büning - Hannover Medical School, previous: Dept. I of Internal Medicine and CMMC

Neumann, Lars (M.Sc.)
Topic: Functional role of PI3K-Delta in malignant B cells
Supervisor: Dr. Günter Krause - Klinik I für Innere Medizin

Schöllhorn, Laura (Dipl.-Biol.)
Topic: Corneal lymphangiogenesis is necessary to induce autoimmune dry eye disease             
Supervisor: Prof. Dr. Claus Cursiefen - Dept. of Ophthalmology and CMMC

Yu, Xiaojie (M. Sc. in Biochemistry and Molecular Biology)
Topic: Overexpressed microRNA-198 is secreted via exosomes from hepatoma cells
Supervisor: Prof. Dr. Margarete Odenthal – Institute for Pathology and CMMC

Abjeet, Joshi (M.Sc.)
Topic: Extrinsic modulation of regenerative pathways differentially affects axonal recovery in pre-clinical models of peripheral nerve disorders
Supervisor: PD Dr. Helmar Lehmann - Dept. of Neurology

Amer, Wafa (M.Sc.)
IPMM Thesis: Comprehensive analysis of disease related nuclear and mitochondrial genes in hepatocellular carcinoma
Supervisor: Prof. Dr. Margarethe Odenthal - Institute for Pathology

Bobylev, Ilja (Dipl. Biol.)
Topic: The role of mitochondria in the pathogenesis of chemotherapy-induced peripheral neuropathy
Supervisor: PD Dr. Helmar Lehmann - Dept. of Neurology

Deshmukh, Jayesh (M.Sc.)
Topic: Epidermal RAC 1 regulates the DNA damage response and protects from UV-light induced skin carcinogenesis and keratinocyte apoptosis
Supervisor: Prof. Ingo Haase / Dr. Sandra Iden - Dept. of Dermatology / CECAD Cologne
Academic Grade: Dr. nat. med. 

Dietlein, Felix (Dr. rer. nat. / Dr. med. cand.)
Topic: A framework to comprehensively identify synergistic drug interactions in cancer
Supervisor: Prof. Dr. Christian Reinhardt - Dept. I of Internal Medicine
Academic Grade: Dr. nat. med.

Faitschuk, Elena (Dipl. Chem.)
Topic: A novel dual chain-based design of a Chimeric Antigen Receptor (CAR) for Adoptive cell therapy and an FcµR-specific CAR for improved targeting of Chronic Lymphocytic Leukemia (CLL)
Supervisor: Prof. Dr. Hinrich Abken - Dept. I of Internal Medicine

Göckeritz, Elisa (M.Sc. - Clinical Molecular Science)

Thesis: Exploring oncogenic functions of malignant B cells by inhibition of PI3K and BTK

Supervisor: Dr. Günter Krause - Dept. I for Internal Medicine 


Hos, Deniz (Dr. med.)
IPMM Thesis: The Contribution of Macrophages to Inflammatory Corneal lymphangiogenesis
Supervisor: Prof. Dr. Claus Cursiefen - Dept. of Ophthalmology

Martyniszyn, Alexandra (Dipl.-Biol.)
Topic: Duales Targeting von malignen B-Zellen mit einem bispezifischen chimären Antigen-Rezeptor (CAR) zur Erkennung von Antigen-Verlustvarianten
Supervisor: Prof. Dr. Hinrich Abken - Dept. I of Internal Medicine / CMMC 

Meder, Lydia (M.Sc.)
Topic: Deciphering the role of NOTCH, ASCL1, p53 and RB in secondary small cell lung carcinomas
Supervisor: PD Dr. Lukas Heukamp - former member Dept. I of Internal Medicine

Sheikh, Miriam (Pharmacist)
Topic: Identification and kinetic characterization of novel inhibitors of Cholesterol Esterase and new insights into the bile salt-induced activation mechanism
Supervisor: Prof. Dr. Stefan Herzing - Institute for Pharmacologyhttp://pharmakologie.uk-koeln.de/de/forschung/stefan-herzig/leiter-der-arbeitsgruppe

Scholz, Rebecca (Dipl.-Oecotroph.)
Topic: Microglia as therapeutic targets in retinal degeneration: role of translocator protein (18 kDa) (TSPO) and minocycline
Supervisor: Prof. Dr. Thomas Langmann - Dept. of Ophtamology, Lab. of Experimental Immunology of the Eye

Volz, Caroline (M.Sc.)
Topic: The role of VGFR2 and EphA2 in tumor cell invasion in non-small-cell lung cancer
Supervisor: PD Dr. Dr. Roland Ullrich - Dept. I of Internal Medicine

Zhang, Liang (Dr. med.)
Topic: Capsid-engineering overcomes barriers towards endothelial cell transduction
Supervisor: Prof. Dr. Hildegard Büning - Dept. I of Internal Medicine / CMMC / present adress: Hannover Medical School

Aslanidis, Alexander (M.Sc.)
Topic: Characterization of photoreceptor gene regulation and modulation of microglial reactivity in the retina
Supervisor: Prof. Dr. Th. Langmann - Dept. of Experimental Immunology of the Eye 

Liu, Yicheng (M.Sc.)
Topic: New insights into the molecular pathogenesis of accelerated aging phenotypes in Hallermann-Streiff and Bloom syndromes
Supervisor: Prof. Dr. Bernd Wollnik - Institute for Human Genetics 

Schmied, Sabine (M.Sc.)
Topic: Characterization of tumor-antigen-specific T cells – insights into WT1- and HPV16-specific T cell repertoires
Supervisor: Dr. Anne Richter / Dr. Mario Assenmacher - Milteny Biotec GmbH

Beleggia, Filippo (M.Sc.)
Topic: Innovative strategies for gene identifaction and functional analysisof progeria syndromes
Supervisor: Prof. Dr. Bernd Wollnik - Institute for Human Genetics

Bohlen, Susanne (M.Sc.)
Topic: NADPH-oxidase derived reactive oxygen species (ROS) regulateStaphylococcus aureus-induced autophagy through PI3K
Supervisor: Dr. Oleg Krut - Institute for Med. Microbiology, Immunology and Hygiene

Chatterjee, Sampurna (M.Sc.)
Topic: VEGFR2 as a biomarker and therapeutic target in non small cell lung cancer
Supervisor: PD Dr. med. Dr. nat. med. Roland Ullrich - Dept. I of Internal Medicine

Dibué-Adjei, Maxine (M.Sc.)
Topic: Mechanisms of the Cav2.3 Calcium Channel’s Role in Epileptogenesis and Antiepileptic Pharmacotherapy
Supervisor: Prof. Dr. T. Schneider - Institute for Neurophysiology

Lehmann, Martin (Dipl.-Biol.)
Topic: A novel model system to study the role of catecholamines in cardiac lineage commitment of embryonic stem cells and functional response to proarrhytmic drugs
Supervisor: Prof. Dr. Jürgen Hescheler - Institute for Neurophysiology

Lichtenauer, Urs (Dr. med.)
Topic: Regulation of adrenocortical growth and steroidogenesis - stem cells and orphan nuclear receptors
Supervisor: Dr. F. Beuschlein - Dept. of Medicine, LMU, München

Seidel, Daniela (Dipl.-Biol.)
Topic: Genomic signatures of clinical phenotypes in non-small cell lung cancer
Supervisor: Prof. Dr. R. Thomas - MPI for Neurological Research, Functional Cancer Genomics

Willkomm, Lena (M.Sc.)
Topic: The effects of lactate on skeletal muscle
Supervisor: Prof. Dr. W. Bloch - Deutsche Sporthochschule

Dafinger, Claudia (Dipl.-Biol.)
Topic: Molekulare Pathogenese des Joubert-Syndroms - die Rolle des Proteins KIF7
Supervisor: Prof. Dr. Th. Benzing - Dept. II of Internal Medicine

Keupp, Katharina (Dipl.-Biol.)
Topic: Novel insights into molecular mechanisms of inherited bone  disorders
Supervisor: Prof. Dr. B. Wollnik - Institute for Human Genetics

Kocak, Hayriye (Dipl.-Biol.)
Topic: Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma
Supervisor: PD Dr. M. Fischer - Dept. of Pediatric Oncology and Hematology

Pohl, Esther (Dipl.-Biol.)
Topic: Molecular pathogenesis of selected autosomal recessively inherited disorders:  from gene to function
Supervisor: Prof. Dr. B. Wollnik - Institute for Human Genetics

Sallach, Jessica (M.Sc.)
Topic: Exploiting high-throughput screens to optimize Adeno-Associated viral vectors for gene transfer into primary human kerationcytes
Supervisor: PD Dr. H. Büning - CMMC / Dept. I of Internal Medicine

Rabenhorst, Anja (Dipl.-Biol.)
Topic: Modulation of tumor microenvironment and anti-tumor immunity by mast cells
Supervisor: PD Dr. K. Hartmann - Dept. of Dermatology

Alcazár, Miguel (Dr. med.)
Topic: Role of neuropeptide Y in lung development: implications in the pathogenesis of chronic lung disease
Supervisor: Prof. Dr. J. Dötsch - Dept. of Pediatrics 

Brüggemann, Sabrina (Dipl.-Biol.)
Topic: Genomic instability and DNA damage response in premature aging syndromes
Supervisor: PD Dr. M. Stoff-Khalili - Institute for Virology 

Esser, Knud (Dipl.-Chem.)
Topic: Das Hepatitis B Virus folgt dem Transport der neutralen Lipide in die Leber und in die Hepatozyten, um seine Wirtszelle zu erreichen und zu infizieren
Supervisor: Prof. Dr. U. Protzer - Institute for Virology Munich (former Inst. for IMMIH Cologne) 

Rother, Eva (Dr. med.)
Topic: Neuroendokrine Kontrolle der Gewichtsregulation
Supervisor: Prof. Dr. J. Brüning - Center for Endocrinology, Diabetology and Preventive Medicine / MPI for Neurological Research / CMMC 

Wen, Tingting (M.Sc.)
Topic: Regulation of Laminin 332 expression
Supervisor: Prof. Dr. M. Aumailley - Institute for Biochemistry II

Plume, Nadine (Dipl.-Biol.)
Topic: Molekulare Mechnismen isolierter und Syndrom-assoziierter Lipidstoffwechselerkrankungen
Supervisor: Dr. B. Wollnik - CMMC-Junior Research Group V / Institute for Human Genetics

Rybniker, Jan (Dr. med.)

Topic: Identification and characterization of host-shut-off proteins of Mycobacteriophages
Supervisor: PD Dr. P. Hartmann - Dept. I of Internal Medicine

Séquaris, Gilles (Dipl.-Biol.)

Topic: Molecular mechanism of Indian Hedgehog signalling in human sebocytes
Supervisor: Dr. C. Niemann - CMMC-Junior Research Group IV

Siebolts, Udo (Dr. med Dipl.- Biol.)

Topic: New aspects into pathophysiology and molecular diagnostics of myeloproliferative neoplasms
Supervisor: Prof. Dr. C. Wickenhauser - Institute for Pathology, Univ. of Leipzig (former Institute for Pathology, Univ. of Cologne)

Vierkotten, Sarah (Dipl.-Biol.)
Topic: HTR1: Ein Kandidatengen für die Altersbedingte Makuladegeneration
Supervisor: PD Dr. S. Fauser - Center of Ophthalmology

Weiß, Jonathan (Dipl.-Biol.)

Topic: Deciphering oncogene dependencies and signaling pathway alterations in non small cell lung cancer
Supervisor: Prof. Dr. R. Thomas - MPI for Neurological Research / JRG Functional Cancer Genomics

Ernst, Marianne (M.Sc.)
Topic: Expression of Foxo 1 versions in the mouse
Supervisor: Prof. Dr. Jens Brüning - Institute for Genetics and CMMC

Gonzalez, Nela Klein (Dr. med.)
Topic: Homing and migration of CD40-activated B cells
Supervisor: Dr. Dr. Michael v. Bergwelt-Baildon - Dept. of Internal Medicine I

Jangsangthong, Wanchana (M.Sc)
Topic: Structural determinants of gating properties of voltage-gated L-type Calcium channels as revealed by single-channel analysis
Supervisor: Prof. Dr. Stefan Herzig - Institute for Pharmacology and CMMC

Pawlik, Barbara (Dipl.-Biol.)
Topic: Molecular mechanisms of congential limb malformations
Supervisor: Dr. Bernd Wollnik - CMMC-Junior Research Group V / Institute for Human Genetics

Petersson, Monika (Dipl.-Biol.)
Topic: Regulation of morphogenesis and tumourigenesis in the skin
Supervisor: Dr. Catherin Niemann - CMMC-Junior Research Group IV
Academic Grade: Dr. rer. nat. 

Uhrig, Silke (Dipl.-Biol.)
Topic: Detailed analysis of cell infection by capsid engineered AAV vectors
Supervisor: PD Dr. Hildegard Büning - Dept. of Internal Medicine I and CMMC 

Ullrich, Roland (Dr. med.)
Topic: Molecular imaging for the quantitative assessment of tumor proliferation, progression and the early assessment of molecular targeted treatment response
Supervisor: Prof. Dr. Andreas Jacobs - EIMI, Univ. of Münster (former Dept. of Neurology, Univ. of Cologne)

Elhamine, Fatiha (Dipl.-Biol.)
Topic: Myofibrillar protein expression and contractility in the right ventricle from infants with congenital heart disease associated with right ventricular outflow obstruction
Supervisor: Prof. G. Pfitzer - Institute for Vegetative Physiology and CMMC 

Hettich, Moritz (Dipl.-Biol.)
Topic: Role of neuronal IGF-1 receptor signaling for the pathogenesis of Alzheimer´s disease
Supervisor: Prof. Dr. W. Krone - Dept. of Internal Medicine II
Academic Grade: Dr. rer. nat. 

Kopacek, Anke (Dipl.-Biol.)
Topic: Generation, expression and functional analysis of recombinant
bi-specific CD3 x NCAM antibodies for the therapy of patients with rezidative neuroblastoma
Supervisor: Prof. F. Berthold - Dept. of Pediatric Oncology & Hematology and CMMC 

Könner, Christine (Dipl.-Biol.)
Topic: Genetic Microdissection of Insulin Action on Neurocircuits in Control of Glucose and Energy Homeostasis
Supervisor: Prof. Dr. Wilhelm Krone - Dept. of Internal Medicine II and CMMC
Academic Grade: Dr. rer. nat. 

Meemboor, Sonja (M.Sc.)
Topic: Streptococcus pneumoniae capsular polysaccharide-mediated CD4+ T cell-dependant abscess formation requires IL-6 and TLR-4
Supervisor: PD Dr. Wiltrud Kalka-Moll - Institute for Medical Microbiology, Immunology and Hygiene 

Pütz, Sandra (Dipl.-Biol.)
Topic: Role of caldesmon in the regulation of smooth muscle actomyosin interaction
Supervisor: Prof. Gabriele Pfitzer - Institute for Vegetative Physiology and CMMC 

Radhakrishnan, Kayalvizhi (M.Sc.)
Topic: Interaction partners of the E-/R-type voltage gated calcium channels which are involved in the phorbolester mediated stimulation of Cav2.3 calcium channel
Supervisor: Prof. Toni Schneider - Institute for Neurophysiology and CMMC
Academic Grade: Dr. rer. nat. 

Schievenbusch, Stephanie (Dipl.-Biol.)
Topic: HGF as a multifunctional and anti-fibrotic-agent with high impact on gene therapy for renal tubulointestitial fibrosis Supervisor Academic Grade 2005
Supervisor: Prof. Dr. Margarete Odenthal - Institute for Pathology

Quasdorff, Maria (Dr. med.)
Topic: Die Bedeutung von Wirtsfaktoren für die Hepatitis B und Hepatitis B Virus-assoziierte hepatozelluläre Karzinome und ihre therapeutische Beeinflussung
Supervisor: Prof. Dr. U. Protzer - Institute for Virology TU Munich
Academic Grade: Dr. nat. med. 

Rohmann, Edyta (Dipl.-Biol.)
Topic: Molekulare Pathogenese arrhythmogener Erkrankungen
Supervisor: Dr. Bernd Wollnik - CMMC-Junior Research Group V / Institute for Human Genetics
Academic Grade: Dr. nat. med. 

Steingen, Caroline (Dipl.-Biol.)
Topic: The relevance of circulating progenitor cells for the regeneration of dysfunctional endothelium
Supervisor: PD Dr. K. Brixius - Institute for Cardiovascular Research, & Sports Medicine, German Sport University of Cologne
Academic Grade: Dr. rer. nat. 

Zedler, Uta (Dipl.-Biol.)
Topic: Fluorescent hepatitis B virus particles. Dendritic cells allow expression of viral antigens but not infection of with hepatitis B virus
Supervisor: Prof. Dr. U. Protzer - Institute for Virology TU Munich

Meyer, Philipp T. (Dr. med.)
Topic: In vivo Quantification of Cerebral A1-Adenosin-Rezeptoren mittels [18F]CPFPX und der Positronen-Emissions-Tomographie: Quantifizierungsmodelle und erste Untersuchungen physiologischer und pathologischer Prozesse
Supervisor: Prof. K. Zilles - Institute for Nuclear Chemistry (INC) Research Center Jülich 

Miletic, Hrvoje (Dr. med.)
Topic: Gene therapy of malignant glioma with lentiviral vectors
Supervisor: Prof. M. Deckert - Dept. of Neuropathology

Schnaith, Annabelle (Pharmazy)
Topic: Identification and characterization of cytotxic factors produced by Staphylococcus aureus
Supervisor: Prof. M. Krönke - Institute for Medical Microbiology, Immunology & Hygiene and CMMC 

Song, Jian (M.Sc.)
Topic: The role of the cytoplasmatic tail of IgG1 B cell receptors in signalling and B cell development
Supervisor: Prof. A. Waisman - I. Medical Department and Polyclinic, University of Mainz (former Institute for Genetics, University of Cologne)

Nussbaum, Tanja (Dipl.-Biol.)
Topic: Funktionelle Aspekte der IGF-II Inhibierung im humanen hepatozellulären Karzinom unter Berücksichtigung möglicher therapeutischer Ansätze
Supervisor: Prof. P. Schirmacher - Institute for Pathology, Univ. of Heidelberg (former Institute for Pathology, Univ. of Cologne)
Academic Grade: Dr. rer. nat. 

Weiergräber, Marco (Dr. med.)
Topic: Funktionelle Charakterisierung des neuronalen E-Typ Ca2+-Kanals im kardio-vaskulären System der Maus
Supervisor: Prof. T. Schneider - Institute for Neurophysiology and CMMC

Schnickmann, Stephanie (Dipl.-Biol.)
Topic: Bedeutung des HGF-MET Signalsystems im Rahmen der epidermalen Wundheilung
Supervisor: Prof. P. Schirmacher - Institute for Pathology, Univ. of Heidelberg (former Institute for Pathology, Univ. of Cologne)
Academic Grade: Dr. rer. nat.