Summary of articles published by CMMC members in 2011

Selected publications related to CMMC-projects are listed in alphabetical order by the first author published in 2010.

  1. Ackermann S, Goeser F, Schulte JH, Schramm A, Ehemann V, Hero B, Eggert A, Berthold F, and Fischer M (2011). Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma. Clin Cancer Res 17, 731-741.

  2. Afanasyeva EA, Mestdagh P, Kumps C, Vandesompele J, Ehemann V, Theissen J, Fischer M, Zapatka M, Brors B, Savelyeva L, Sagulenko V, Speleman F, Schwab M, and Westermann F (2011). MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival. Cell Death Differ 18, 974-984.

  3. Akgul B, Bauer B, Zigrino P, Storey A, Mauch C, and Pfister H (2011). Upregulation of lipocalin-2 in human papillomavirus-positive keratinocytes and cutaneous squamous cell carcinomas. J Gen Virol 92, 395-401.

  4. Alikhani N, Berglund AK, Engmann T, Spanning E, Vogtle FN, Pavlov P, Meisinger C, Langer T, and Glaser E (2011). Targeting Capacity and Conservation of PreP Homologues Localization in Mitochondria of Different Species. J Mol Bio 410, 400-410.

  5. Alnawaiseh M, Albanna W, Chen CC, Campbell KP, Hescheler J, Luke M, and Schneider T (2011). Two separate Ni(2+) -sensitive voltage-gated Ca(2+) channels modulate transretinal signalling in the isolated murine retina. Acta Ophthalmol 89, e579-e590.

  6. Anton F, Fres JM, Schauss A, Pinson B, Praefcke GJ, Langer T, and Escobar-Henriques M (2011). Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion. J Cell Sci 124, 1126-1135.

  7. Arweiler-Harbeck D, Horsthemke B, Jahnke K, and Hennies HC   (2011). Genetic Aspects of Familial Meniere's Disease. Otology & Neurotology 32, 695-700.

  8. Bareyre FM, Garzorz N, Lang C, Misgeld T, Buning H, and Kerschensteiner M (2011). In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration. Proc Natl Acad Sci U S A 108, 6282-6287.

  9. Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JFG, Schauen M, Wille A, Muller A, Merkwirth C, Langer T, Larsson NG, Krieg T, Tobin DJ, Paus R, and Wiesner RJ (2011). The Mitochondrial Electron Transport Chain Is Dispensable for Proliferation and Differentiation of Epidermal Progenitor Cells. Stem Cells 29, 1459-1468.

  10. Becker J, Semler O, Gilissen C, Li Y, Bolz HJ, Giunta C, Bergmann C, Rohrbach M, Koerber F, Zimmermann K, de Vries P, Wirth B, Schoenau E, Wollnik B, Veltman JA, Hoischen A, and Netzer C (2011). Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta. Am J Hum Genet 88, 362-371.

  11. Benzing T, and Schermer B (2011).Transition zone proteins and cilia dynamics. Nat Genet 43, 723-724.

  12. Beyer M, Thabet Y, Muller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou XY, Bailey-Bucktrout SL, Krebs W, Schonfeld EA, Bottcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL, and Schultze JL (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol 12, 898-U125.

  13. Bilkovski R, Schulte DM, Oberhauser F, Mauer J, Hampel B, Gutschow C, Krone W, and Laudes M (2011). Adipose tissue macrophages inhibit adipogenesis of mesenchymal precursor cells via wnt-5a in humans. Int J Obes (Lond) 35, 1450-1454.

  14. Bissels U, Wild S, Tomiuk S, Hafner M, Scheel H, Mihailovic A, Choi YH, Tuschl T, and Bosio A (2011). Combined Characterization of microRNa and mRNa Profiles Delineates Early Differentiation Pathways of CD133(+) and CD34(+) Hematopoietic Stem and Progenitor Cells. Stem Cells 29, 847-857.

  15. Blaydon DC, Nitoiu D, Eckl KM, Cabral RM, Bland P, Hausser I, van Heel DA, Rajpopat S, Fischer J, Oji V, Zvulunov A, Traupe H, Hennies HC  , and Kelsell DP (2011). Mutations in CSTA, Encoding Cystatin A, Underlie Exfoliative Ichthyosis and Reveal a Role for This Protease Inhibitor in Cell-Cell Adhesion. Am J Hum Genet 89, 564-571.

  16. Bock G, Gebhart M, Scharinger A, Jangsangthong W, Busquet P, Poggiani C, Sartori S, Mangoni ME, Sinnegger-Brauns MJ, Herzig S, Striessnig J, and Koschak A (2011). Functional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels. J Biol Chem, 286, 42736-48.

  17. Bonn F, Tatsuta T, Petrungaro C, Riemer J, and Langer T (2011). Presequence-dependent folding ensures MrpL32 processing by the m-AAA protease in mitochondria. Embo Journal 30, 2545-2556.

  18. Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, and Pasparakis M (2011). The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 35, 572-582.

  19. Borck G, Ur Rehman A, Lee K, Pogoda HM, Kakar N, von Ameln S, Grillet N, Hildebrand MS, Ahmed ZM, Nurnberg G, Ansar M, Basit S, Javed Q, Morell RJ, Nasreen N, Shearer AE, Ahmad A, Kahrizi K, Shaikh RS, Ali RA, Khan SN, Goebel I, Meyer NC, Kimberling WJ, Webster JA, Stephan DA, Schiller MR, Bahlo M, Najmabadi H, Gillespie PG, Nuernberg P, Wollnik B, Riazuddin S, Smith RJ, Ahmad W, Muller U, Hammerschmidt M, Friedman TB, Leal SM, Ahmad J, and Kubisch C (2011). Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42. Am J Hum Genet 88, 127-137.

  20. Borck G, Wunram H, Steiert A, Volk AE, Korber F, Roters S, Herkenrath P, Wollnik B, Morris-Rosendahl DJ, and Kubisch C (2011). A homozygous RAB3GAP2 mutation causes Warburg Micro syndrome. Hum Genet 129, 45-50.

  21. Bouter A, Gounou C, Berat R, Tan S, Gallois B, Granier T, d'Estaintot BL, Poschl E, Brachvogel B, and Brisson AR (2011). Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair. Nat Commun 2, 270.

  22. Brellier F, Ruggiero S, Zwolanek D, Martina E, Hess D, Brown-Luedi M, Hartmann U, Koch M, Merlo A, Lino M, and Chiquet-Ehrismann R (2011). SMOC1 is a tenascin-C interacting protein over-expressed in brain tumors. Matrix Biol 30, 225-233.

  23. Caglayan E, Vantler M, Leppanen O, Gerhardt F, Mustafov L, ten Freyhaus H, Kappert K, Odenthal M, Zimmermann WH, Tallquist MD, and Rosenkranz S (2011). Disruption of Platelet-Derived Growth Factor-Dependent Phosphatidylinositol 3-Kinase and Phospholipase C gamma 1 Activity Abolishes Vascular Smooth Muscle Cell Proliferation and Migration and Attenuates Neointima Formation In Vivo. J Am Coll Cardiol 57, 2527-2538.

  24. Chaudhry A, Samstein RM, Treuting P, Liang YQ, Pils MC, Heinrich JM, Jack RS, Wunderlich FT, Bruning JC, Muller W, and Rudensky AY (2011). Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation. Immunity 34, 566-578.

  25. Chiang LY, Poole K, Oliveira BE, Duarte N, Sierra YAB, Bruckner-Tuderman L, Koch M, Hu J, and Lewin GR (2011). Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons. Nat Neurosci 14, 993-U979.

  26. Chmielewski M, Hombach AA, and Abken H (2011). CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack. Gene Ther 18, 62-72.

  27. Chmielewski M, Kopecky C, Hombach AA, and Abken H (2011). IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression. Cancer Res 71, 5697-5706.

  28. Choi YH, Saric T, Nasseri B, Huhn S, Van Linthout S, Hetzer R, Tschope C, and Stamm C (2011) Cardiac cell therapies: the next generation. Cardiovasc Ther 29, 2-16.

  29. Cianfarani F, Bernardini S, De Luca N, Dellambra E, Tatangelo L, Tiveron C, Niessen CM, Zambruno G, Castiglia D, and Odorisio T (2011) Impaired keratinocyte proliferative and clonogenic potential in transgenic mice overexpressing 14-3-3sigma in the epidermis. J Invest Dermatol 131, 1821-1829.

  30. Dafinger C, Liebau MC, Elsayed SM, Hellenbroich Y, Boltshauser E, Korenke GC, Fabretti F, Janecke AR, Ebermann I, Nurnberg G, Nuernberg P, Zentgraf H, Koerber F, Addicks K, Elsobky E, Benzing T, Schermer B, and Bolz HJ (2011). Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J Clin Invest 121, 2662-2667.

  31. de Kreuk BJ, Nethe M, Fernandez-Borja M, Anthony EC, Hensbergen PJ, Deelder AM, Plomann M, and Hordijk PL (2011). The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. J Cell Sci 124, 2375-2388.

  32. Dolmans GH, Werker PM, Hennies HC, Furniss D, Festen EA, Franke L, Becker K, van der Vlies P, Wolffenbuttel BH, Tinschert S, Toliat MR, Nothnagel M, Franke A, Klopp N, Wichmann HE, Nuernberg P, Giele H, Ophoff RA, Wijmenga C, Grp DDS, Grp GDS, Study LC, and Consortium B-G (2011). Wnt Signaling and Dupuytren's Disease. New Engl J Med 365, 307-317.

  33. Draube A, Klein-Gonzalez N, Mattheus S, Brillant C, Hellmich M, Engert A, and von Bergwelt-Baildon M (2011). Dendritic Cell Based Tumor Vaccination in Prostate and Renal Cell Cancer: A Systematic Review and Meta-Analysis. Plos One 6. e18801

  34. Dykstra T, Utermoehlen O, and Haas A (2011). Defined particle ligands trigger specific defense mechanisms of macrophages. Innate Immun 17, 388-402.

  35. Eckl KM, Alef T, Torres S, and Hennies HC   (2011). Full-Thickness Human Skin Models for Congenital Ichthyosis and Related Keratinization Disorders. J Invest Dermatol 131, 1938-1942.

  36. Ehlken H, Kondylis V, Heinrichsdorff J, Ochoa-Callejero L, Roskams T, and Pasparakis M (2011). Hepatocyte IKK2 Protects Mdr2 Mice from Chronic Liver Failure. PLoS One 6, e25942.

  37. Eigentler TK, Figl A, Krex D, Mohr P, Mauch C, Rass K, Bostroem A, Heese O, Koelbl O, Garbe C, and Schadendorf D (2011). Number of metastases, serum lactate dehydrogenase level, and type of treatment are prognostic factors in patients with brain metastases of malignant melanoma. Cancer 117, 1697-1703.

  38. Eming SA, and Hubbell JA (2011). Extracellular matrix in angiogenesis: dynamic structures with translational potential. Exp Dermatol 20, 605-613.

  39. Fatima A, Xu G, Kaifeng S, Papadopoulos S, da Rosa A, Arnaiz Cot JJ, Lehmann M, Nguemo F, Matzkies M, Dittmann S, Stone SL, Linke M, Zechner U, Beyer V, Hennies HC, Rosenkranz S, Klauke B, Farr M, Parwani AS, Cleemann L, Morad M, Milting H, Hescheler J, and Šarić T (2011). In vitro modeling of ryanodine receptor 2 dysfunction using induced pluripotent stem cells. Cell Physiol Biochem 28, 579-592.

  40. Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser S, Michels C, Gunschmann C, Sandhoff K, Niessen CM, and Niemann C (2011). TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function. J Invest Dermatol 132, 337-345.

  41. Feitosa NM, Richardson R, Bloch W, and Hammerschmidt M (2011). Basement membrane diseases in zebrafish. Meth Cell Biol 105, 191-222.

  42. Feldkirchner S, Mueller S, Kress W, Hanisch FG, Schoser B, and Schessl J (2011). Evaluation of standardized protein pattern of skeletal muscle fibers via laser microdissection. Neuromuscular Disord 21, 739-740.

  43. Feldkirchner S, Walter MC, Kubny C, Mueller S, Kress W, Hanisch FG, Schoser B, and Schessl J (2011). The C224W FHL1 mutation is causing a protein aggregation disorder of muscle: Two brothers revisited. Neuromuscular Disord 21, 740.

  44. Frenzel LP, Patz M, Pallasch CP, Brinker R, Claasen J, Schulz A, Hallek M, Kashkar H, and Wendtner CM (2011). Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis. Brit J Haematol 152, 191-200.

  45. Gahete MD, Cordoba-Chacon J, Anadumaka CV, Lin Q, Bruning JC, Kahn CR, Luque RM, and Kineman RD (2011). Elevated GH/IGF-I, Due to Somatotrope-Specific Loss of Both IGF-I and Insulin Receptors, Alters Glucose Homeostasis and Insulin Sensitivity in a Diet-Dependent Manner. Endocrinology 152, 4852-4837.

  46. Galldiks N, Burghaus L, Dohmen C, Teschner S, Pollok M, Leebmann J, Frischmuth N, Hollinger P, Nazli N, Fassbender C, Klingel R, Benzing T, Fink GR, and Haupt WF (2011). Immunoadsorption in Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy with Unsatisfactory Response to First-Line Treatment. Eur Neurol 66, 183-189.

  47. Gara SK, Grumati P, Squarzoni S, Sabatelli P, Urciuolo A, Bonaldo P, Paulsson M, and Wagener R (2011). Differential and restricted expression of novel collagen VI chains in mouse. Matrix Biology 30, 248-257.

  48. Gerdes F, Tatsuta T, and Langer T (2011). Mitochondrial AAA proteases - Towards a molecular understanding of membrane-bound proteolytic machines. Biochim Biophys Acta 1823, 49-55.

  49. Grellscheid S*, Dalgliesh C*, Storbeck S*, Best A, Liu Y, Jakubik M, Mende Y, Ehrmann I, Curk T, Kristina Rossbach K, Bourgeois CF, Stevenin J, Grellscheid D, Jackson MS, Wirth B and Elliott DJ (2011) A transcriptome-wide analysis identifies evolutionarily conserved exons as regulated targets for the splicing activator Tra2β. Plos Genetics, e1002390.

  50. Groma G, Grskovic I, Schael S, Ehlen HWA, Wagener R, Fosang A, Aszodi A, Paulsson M, Brachvogel B, and Zaucke F (2011). Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state. Matrix Biol 30, 275-280.

  51. Habbig S, Bartram M, Mueller RU, Schwarz R, Saegmueller J, Liebau M, Benzing T, and Schermer B (2011). Nephrozystin-4 is a negative regulator of hippo signaling. Pediatr Nephrol 26, 1722-1722.

  52. Habbig S, Bartram MP, Muller RU, Schwarz R, Andriopoulos N, Chen SH, Sogmuller JG, Hoehne M, Burst V, Liebau MC, Reinhardt HC, Benzing T, and Schermer B (2011). NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. J Cell Biol 193, 633-642.

  53. Hanisch FG (2011). Top-Down Sequencing of O-Glycoproteins by In-Source Decay Matrix-Assisted Laser Desorption Ionization Mass Spectrometry for Glycosylation Site Analysis. Analytical Chemistry 83, 4829-4837.

  54. Hansen U, Platz N, Becker A, Bruckner P, Paulsson M, and Zaucke F (2011). A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis. Arthritis Rheum 63, 159-167.

  55. Hedrych-Ozimina A, Behrendt K, Hao Z, Pofahl R, Ussath D, Knaup R, Krieg T, and Haase I (2011). Enhanced contact allergen- and UVB-induced keratinocyte apoptosis in the absence of CD95/Fas/Apo-1. Cell Death Differ 18, 155-163.

  56. Heeringa SF, Chernin G, Chaki M, Zhou W, Sloan AJ, Ji Z, Xie LX, Salviati L, Hurd TW, Vega-Warner V, Killen PD, Raphael Y, Ashraf S, Ovunc B, Schoeb DS, McLaughlin HM, Airik R, Vlangos CN, Gbadegesin R, Hinkes B, Saisawat P, Trevisson E, Doimo M, Casarin A, Pertegato V, Giorgi G, Prokisch H, Rotig A, Nurnberg G, Becker C, Wang S, Ozaltin F, Topaloglu R, Bakkaloglu A, Bakkaloglu SA, Muller D, Beissert A, Mir S, Berdeli A, Varpizen S, Zenker M, Matejas V, Santos-Ocana C, Navas P, Kusakabe T, Kispert A, Akman S, Soliman NA, Krick S, Mundel P, Reiser J, Nuernberg P, Clarke CF, Wiggins RC, Faul C, and Hildebrandt F (2011). COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 121, 2013-2024.

  57. Heidel AJ, Lawal HM, Felder M, Schilde C, Helps NR, Tunggal B, Rivero F, John U, Schleicher M, Eichinger L, Platzer M, Noegel AA, Schaap P, and Glockner G (2011). Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res 21, 1882-1891.

  58. Henrich KO, Bauer T, Schulte J, Ehemann V, Deubzer H, Gogolin S, Muth D, Fischer M, Benner A, König R, Schwab M & Westermann F (2011). CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programmes in neuroblastoma cells. Cancer Res, 71, 3142-3151.

  59. Hildebrandt F, Benzing T, and Katsanis N (2011). Mechanisms of Disease: Ciliopathies. New Engl J Med 364, 1533-1543.

  60. Hinrichs S, Heger J, Schreckenberg R, Wenzel S, Euler G, Arens C, Bader M, Rosenkranz S, Caglayan E, and Schluter KD (2011). Controlling cardiomyocyte length: the role of renin and PPAR-gamma. Cardiovasc Res 89, 344-352.

  61. Hoffmann DC, Textoris C, Oehme F, Klaassen T, Goppelt A, Romer A, Fugmann B, Davidson JM, Werner S, Krieg T, and Eming SA (2011). Pivotal Role for alpha 1-Antichymotrypsin in Skin Repair. J Biol Chem 286, 28889-28901.

  62. Hohne M, Lorscheider J, von Bardeleben A, Dufner M, Scharf MA, Godel M, Helmstadter M, Schurek EM, Zank S, Gerke P, Kurschat C, Sivritas SH, Neumann-Haefelin E, Huber TB, Reinhardt HC, Schauss AC, Schermer B, Fischbach KF, and Benzing T (2011). The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins. Mol Cell Biol 31, 3241-3251.

  63. Hombach AA, and Abken H (2011).Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling. Int J Cancer 129, 2935-2944.

  64. Hornle M, Peters N, Thayaparasingham B, Vorsmann H, Kashkar H, and Kulms D (2011). Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis. Oncogene 30, 575-587.

  65. Hoesel M, Broxtermann M, Janicki H, Esser K, Arzberger S, Hartmann P, Gillen S, Kleeff J, Stabenow D, Odenthal M, Knolle P, Hallek M, Protzer U, and Buening H (2011). TLR2-mediated innate immune response in human non-parenchymal liver cells towards adeno-associated viral (AAV) vectors. Hepatology 55,287-297.

  66. Huang L, Szymanska K, Jensen VL, Janecke AR, Innes AM, Davis EE, Frosk P, Li C, Willer JR, Chodirker BN, Greenberg CR, McLeod DR, Bernier FP, Chudley AE, Müller T, Shboul M, Logan CV, Loucks CM, Beaulieu CL, Bowie RV, Bell SM, Adkins J, Zuniga FI, Ross KD, Wang J, Ban MR, Becker C, Nürnberg P, Douglas S, Craft CM, Akimenko MA, Hegele RA, Ober C, Utermann G, Bolz HJ, Bulman DE, Katsanis N, Blacque OE, Doherty D, Parboosingh JS, Leroux MR, Johnson CA, Boycott KM (2011). TMEM237 Is Mutated in Individuals with a Joubert Syndrome Related Disorder and Expands the Role of the TMEM Family at the Ciliary Transition Zone. Am J Hum Genet  89,713-30.

  67. Huebner AK, Gandia M, Frommolt P, Maak A, Wicklein EM, Thiele H, Altmüller J, Wagner F, Viñuela A, Aguirre LA, Moreno F, Maier H, Rau I, Giesselmann S, Nürnberg G, Gal A, Nürnberg P, Hübner CA, del Castillo I, Kurth I (2011). Nonsense mutations in SMPX, encoding a protein responsive to physical force, result in X-chromosomal hearing loss. Am J Hum Genet 88, 621-7.

  68. Hufbauer M, Lazic D, Reinartz M, Akgul B, Pfister H, and Weissenborn SJ (2011). Skin tumor formation in human papillomavirus 8 transgenic mice is associated with a deregulation of oncogenic miRNAs and their tumor suppressive targets. J Dermatol Sci 64, 7-15.

  69. Hult S, Soylu R, Bjorklund T, Belgardt BF, Mauer J, Bruning JC, Kirik D, and Petersen A (2011). Mutant Huntingtin Causes Metabolic Imbalance by Disruption of Hypothalamic Neurocircuits. Cell Metabolism 13, 428-439.

  70. Huntgeburth M, La Rosee K, ten Freyhaus H, Bohm M, Schnabel P, Hellmich M, and Rosenkranz S (2011). The Arg389Gly beta(1)-adrenoceptor gene polymorphism influences the acute effects of beta-adrenoceptor blockade on contractility in the human heart. Clin Res Cardiol 100, 641-647.

  71. Huntgeburth M, Laudes M, Burst V, Kramer S, Reuter H, and Rosenkranz S (2011). Acute cardiac arrest secondary to severe hyperkalemia due to autoimmune polyendocrine syndrome type II. Clin Res Cardiol 100, 379-382.

  72. Ikeda F, Deribe YL, Skanland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, and Dikic I (2011). SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Nature 471, 637-641.

  73. Illich DJ, Demir N, Stojkovic M, Scheer M, Rothamel D, Neugebauer J, Hescheler J, and Zoller JE (2011). Concise review: induced pluripotent stem cells and lineage reprogramming: prospects for bone regeneration. Stem Cells 29, 555-563.

  74. Iorga B, Neacsu CD, Neiss WF, Wagener R, Paulsson M, Stehle R, and Pfitzer G (2011). Micromechanical function of myofibrils isolated from skeletal and cardiac muscles of the zebrafish. J Gen Physiol 137, 255-270.

  75. Izu Y, Sun M, Zwolanek D, Veit G, Williams V, Cha B, Jepsen KJ, Koch M, and Birk DE (2011). Type XII collagen regulates osteoblast polarity and communication during bone formation. J Cell Biol 193, 1115-1130.

  76. Jangsangthong W, Kuzmenkina E Böhnke AK, Herzig S (2011) Single-Channel Monitoring of Reversible L-Type Ca2+ Channel CaValpha1-Subunit Interaction. Biophysical Journal 101, 2661-2670.

  77. John von Freyend, M., Untergasser, A., Arzberger, S., Oberwinkler, H., Drebber, U., Schirmacher, P., and Protzer, U. (2011). Sequential control of hepatitis B virus in a mouse model of acute, self-resolving hepatitis B. J Viral Hepat,18, 216-26.

  78. Jordan SD, Kruger M, Willmes DM, Redemann N, Wunderlich FT, Bronneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Bottger T, Braun T, Seibler J, and Bruning JC (2011). Obesity-induced over expression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nature Cell Biology 13, 434-464.

  79. Kalay E, Yigit G, Aslan Y, Brown KE, Pohl E, Bicknell LS, Kayserili H, Li Y, Tuysuz B, Nurnberg G, Kiess W, Koegl M, Baessmann I, Buruk K, Toraman B, Kayipmaz S, Kul S, Ikbal M, Turner DJ, Taylor MS, Aerts J, Scott C, Milstein K, Dollfus H, Wieczorek D, Brunner HG, Hurles M, Jackson AP, Rauch A, Nuernberg P, Karaguzel A, and Wollnik B (2011). CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat Genet 43, 23-26.

  80. Kardakaris R, Gareus R, Xanthoulea S, and Pasparakis M (2011). Endothelial and macrophage-specific deficiency of P38alpha MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice. PLoS One 6, e21055.

  81. Kirschner N, Haftek M, Niessen CM, Behne MJ, Furuse M, Moll I, and Brandner JM (2011). CD44 regulates tight-junction assembly and barrier function. J Invest Dermatol 131, 932-943.

  82. Klatt AR, Becker AKA, Neacsu CD, Paulsson M, and Wagener R (2011). The matrilins: Modulators of extracellular matrix assembly. Int J Biochem Cell Biol 43, 320-330.

  83. Klockener T, Hess S, Belgardt BF, Paeger L, Verhagen LAW, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, and Bruning JC (2011). High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nature Neuroscience 14, 911-918.

  84. Koch M, Hussein F, Woeste A, Grundker C, Frontzek K, Emons G, and Hawighorst T (2011). CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo. Breast Cancer Res Tr 128, 337-346.

  85. Kofler DM, Chmielewski M, Rappl G, Hombach A, Riet T, Schmidt A, Hombach AA, Wendtner CM, and Abken H (2011). CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation. Mol Ther 19, 760-767.

  86. Konner AC, and Bruning JC (2011). Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol Metab 22, 16-23.

  87. Konner AC, Hess S, Tovar S, Mesaros A, Sanchez-Lasheras C, Evers N, Verhagen LAW, Bronneke HS, Kleinridders A, Hampel B, Kloppenburg P, and Bruning JC (2011). Role for Insulin Signaling in Catecholaminergic Neurons in Control of Energy Homeostasis. Cell Metabolism 13, 720-728.

  88. Krenzer S, Peterziel H, Mauch C, Blaber SI, Blaber M, Angel P, and Hess J (2011). Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol 131, 2281-2288.

  89. Kriegeskorte A, Konig S, Sander G, Pirkl A, Mahabir E, Proctor RA, von Eiff C, Peters G, and Becker K (2011). Small colony variants of Staphylococcus aureus reveal distinct protein profiles. Proteomics 11, 2476-2490.

  90. Krone W, Hanefeld M, Meyer HF, Jung T, Bartlett M, Yeh CM, Rajman I, Prescott MF, and Dole WP (2011). Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome. J Hum Hypertens 25, 186-195.

  91. Krug C, Birkholz K, Abken H, Schwenkert M, Fey G, Schuler G, Dorrie J, and Schaft N (2011). Reprogramming T cells with MHC-independent chimeric antigen receptors specific for MCSP. Exp Dermatol 20, 183-184.

  92. Küchler S, Henkes D, Eckl KM, Ackermann K, Plendl J, Korting HC, Hennies HC, and Schäfer-Korting M (2011). Hallmarks of atopic skin in vitro – mimicked by the means of a skin disease model based on FLG knock down. Altern Lab Anim 39, 471-480.

  93. Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, Eckardt K, Kaufmann JM, Ryden M, Mueller S, Hanisch FG, Ruige J, Arner P, Sell H, Eckel J (2011) Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes 60, 1917-1925.

  94. Laue K, Pogoda HM, Daniel PB, van Haeringen A, Alanay Y, von Ameln S, Rachwalski M, Morgan T, Gray MJ, Breuning MH, Sawyer GM, Sutherland-Smith AJ, Nikkels PG, Kubisch C, Bloch W, Wollnik B, Hammerschmidt M, and Robertson SP (2011). Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid. Am J Hum Genet 89, 595-606.

  95. Lee S, Augustin S, Tatsuta T, Gerdes F, Langer T, and Tsai FTF (2011). Electron Cryomicroscopy Structure of a Membrane-anchored Mitochondrial AAA Protease. Journal of Biological Chemistry 286, 4404-4411.

  96. Li P, Cavallero S, Gu Y, Chen THP, Hughes J, Hassan AB, Bruning JC, Pashmforoush M, and Sucov HM (2011). IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development 138, 1795-1805.

  97. Li Y, Bogershausen N, Alanay Y, Simsek Kiper PO, Plume N, Keupp K, Pohl E, Pawlik B, Rachwalski M, Milz E, Thoenes M, Albrecht B, Prott EC, Lehmkuhler M, Demuth S, Utine GE, Boduroglu K, Frankenbusch K, Borck G, Gillessen-Kaesbach G, Yigit G, Wieczorek D, and Wollnik B (2011). A mutation screen in patients with Kabuki syndrome. Hum Genet 130, 715-724.

  98. Liebau MC, Hopker K, Muller RU, Schmedding I, Zank S, Schairer B, Fabretti F, Hohne M, Bartram MP, Dafinger C, Hackl M, Burst V, Habbig S, Zentgraf H, Blaukat A, Walz G, Benzing T, and Schermer B (2011). Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J Biol Chem 286, 14237-14245.

  99. Loehr H, and Hammerschmidt M (2011). Zebrafish in Endocrine Systems: Recent Advances and Implications for Human Disease. Ann Rev Physiol, Vol 73, 183-211.

  100. Martino MM, Tortelli F, Mochizuki M, Traub S, Ben-David D, Kuhn GA, Muller R, Livne E, Eming SA, and Hubbell JA (2011). Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing. Sci Translat Med 3, 100ra89

  101. Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Guire CM, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, and van Loo G (2011). A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet 43, 908-912.

  102. Meng H, Tian L, Zhou J, Li Z, Jiao X, Li WW, Plomann M, Xu Z, Lisanti MP, Wang C, and Pestell RG (2011). PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b. Cell Cycle 10, 73-81.

  103. Miller SE, Sahlender DA, Graham SC, HöningS, Robinson MS, Peden AA, and Owen DJ (2011). The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell 147, 1118-1131.

  104. Milne RL, Goode EL, Garcia-Closas M, Couch FJ, Severi G, Hein R, Fredericksen Z, Malats N, Zamora MP, Arias Perez JI, Benitez J, Dork T, Schurmann P, Karstens JH, Hillemanns P, Cox A, Brock IW, Elliot G, Cross SS, Seal S, Turnbull C, Renwick A, Rahman N, Shen CY, Yu JC, Huang CS, Hou MF, Nordestgaard BG, Bojesen SE, Lanng C, Grenaker Alnaes G, Kristensen V, Borrensen-Dale AL, Hopper JL, Dite GS, Apicella C, Southey MC, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Sangrajrang S, Gaborieau V, Brennan P, McKay J, Chang-Claude J, Wang-Gohrke S, Radice P, Peterlongo P, Manoukian S, Barile M, Giles GG, Baglietto L, John EM, Miron A, Chanock SJ, Lissowska J, Sherman ME, Figueroa JD, Bogdanova NV, Antonenkova NN, Zalutsky IV, Rogov YI, Fasching PA, Bayer CM, Ekici AB, Beckmann MW, Brenner H, Muller H, Arndt V, Stegmaier C, Andrulis IL, Knight JA, Glendon G, Mulligan AM, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Meindl A, Heil J, Bartram CR, Schmutzler RK, Thomas GD, Hoover RN, Fletcher O, Gibson LJ, dos Santos Silva I, Peto J, Nickels S, Flesch-Janys D, Anton-Culver H, Ziogas A, Sawyer E, Tomlinson I, Kerin M, Miller N, Schmidt MK, Broeks A, Van 't Veer LJ, Tollenaar RA, Pharoah PD, Dunning AM, Pooley KA, Marme F, Schneeweiss A, Sohn C, Burwinkel B, Jakubowska A, Lubinski J, Jaworska K, Durda K, Kang D, Yoo KY, Noh DY, Ahn SH, Hunter DJ, Hankinson SE, Kraft P, Lindstrom S, Chen X, Beesley J, Hamann U, Harth V, Justenhoven C, Winqvist R, Pylkas K, Jukkola-Vuorinen A, Grip M, Hooning M, Hollestelle A, Oldenburg RA, Tilanus-Linthorst M, Khusnutdinova E, Bermisheva M, Prokofieva D, Farahtdinova A, Olson JE, Wang X, Humphreys MK, Wang Q, Chenevix-Trench G, and Easton DF (2011). Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer. Cancer Epidemiol Biomarkers Prev 20, 2222-2231.

  105. Mokkapati S, Fleger-Weckmann A, Bechtel M, Koch M, Breitkreutz D, Mayer U, Smyth N, and Nischt R (2011). Basement Membrane Deposition of Nidogen 1 but Not Nidogen 2 Requires the Nidogen Binding Module of the Laminin gamma 1 Chain. Journal of Biological Chemistry 286, 1911-1918.

  106. Mueller RU, Zank S, Fabretti F, and Benzing T (2011). Caenorhabditis elegans, a model organism for kidney research: from cilia to mechanosensation and longevity. Curr Opin Nephrol Hy 20, 400-408.

  107. Mutsaers CA, Wishart TM, Lamont DJ, Riessland M, Schreml J, Comley LH, Murray LM, Parson SH, Lochmuller H, Wirth B, Talbot K, and Gillingwater TH (2011). Reversible molecular pathology of skeletal muscle in spinal muscular atrophy. Hum Mol Genet 20, 4334-4344.

  108. Neacsu CD, Grosch M, Tejada M, Winterpacht A, Paulsson M, Wagener R, Tagariello A (2011). Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate γ-carboxylation. Matrix Biol. 30, 369-78.

  109. Niessen CM, Leckband D, and Yap AS (2011). Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol Rev 91, 691-731.

  110. Noegel AA, Neumann S (2011). The role of Nesprins as multifunctional organizers in the nucleus and the cytoskeleton. Biochem Soc Trans 39, 1725-1728.

  111. Nolle A, Zeug A, van Bergeijk J, Tonges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, J OF, Kumar Srivastav R, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, and Claus P (2011). The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin. Hum Mol Genet 20, 4865-4878.

  112. Ogino K, Ramsden SL, Keib N, Schwarz G, Harvey RJ, and Hirata H (2011). Duplicated gephyrin genes showing distinct tissue distribution and alternative splicing patterns mediate molybdenum cofactor biosynthesis, glycine receptor clustering, and escape behavior in zebrafish. J Biol Chem 286, 806-817.

  113. Oldak M, Tolzmann L, Wnorowski A, Podgorska MJ, Silling S, Lin R, Hiscott J, Muller CS, Vogt T, Smola H, and Smola S (2011). Differential regulation of human papillomavirus type 8 by interferon regulatory factors 3 and 7. J Virol 85, 178-188.

  114. Oliveira EE, Schleicher S, Buschges A, Schmidt J, Kloppenburg P, and Salgado VL (2011). Desensitization of nicotinic acetylcholine receptors in central nervous system neurons of the stick insect (Carausius morosus) by imidacloprid and sulfoximine insecticides. Insect Biochem Mol Biol 41, 872-880.

  115. Osman C, Voelker DR, and Langer T (2011). Making heads or tails of phospholipids in mitochondria. J Cell Biol 192, 7-16.

  116. Park JS, Mehta P, Cooper AA, Veivers D, Heimbach A, Stiller B, Kubisch C, Fung VS, Krainc D, Mackay-Sim A, and Sue CM (2011). Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism. Hum Mutat 32, 956-964.

  117. Pasquier E, Kieran MW, Sterba J, Shaked Y, Baruchel S, Oberlin O, Kivivuori MS, Peyrl A, Diawarra M, Casanova M, Zacharoulis S, Vassal G, Berthold F, Verschuur A, and Andre N (2011). Moving forward with metronomic chemotherapy: meeting report of the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology. Transl Oncol 4, 203-211.

  118. Petersson M, Brylka H, Kraus A, John S, Rappl G, Schettina P, and Niemann C (2011). TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis. EMBO J 30, 3004-3018.

  119. Pierson TM, Adams D, Bonn F, Martinelli P, Cherukuri PF, Teer JK, Hansen NF, Cruz P, Mullikin For The Nisc Comparative Sequencing Program JC, Blakesley RW, Golas G, Kwan J, Sandler A, Fuentes Fajardo K, Markello T, Tifft C, Blackstone C, Rugarli EI, Langer T, Gahl WA, and Toro C (2011). Whole-Exome Sequencing Identifies Homozygous AFG3L2 Mutations in a Spastic Ataxia-Neuropathy Syndrome Linked to Mitochondrial m-AAA Proteases. PLoS Genet 7, e1002325.

  120. Praefcke GJ, Hofmann K, and Dohmen RJ (2011). SUMO playing tag with ubiquitin. Trends Biochem Sci 37, 23-31.

  121. Raasch J, Zeller N, van Loo G, Merkler D, Mildner A, Erny D, Knobeloch KP, Bethea JR, Waisman A, Knust M, Del Turco D, Deller T, Blank T, Priller J, Bruck W, Pasparakis M, and Prinz M (2011). IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system. Brain 134, 1184-1198.

  122. Radhakrishnan K, Kamp MA, Siapich SA, Hescheler J, Luke M, and Schneider T (2011a). Ca(v)2.3 Ca2+ channel interacts with the G1-subunit of V-ATPase. Cell Physiol Biochem 27, 421-432.

  123. Radhakrishnan K, Krieger A, Dibue M, Hescheler J, and Schneider T (2011). APLP1 and Rab5A Interact with the II-III loop of the Voltage-gated Ca-channel Ca(v)2.3 and Modulate its Internalization Differently. Cell Physiol Biochem 28, 603-612.

  124. Radhakrishnan K, Krieger A, Tevoufouet EE, Dietz GPH, Nagel F, Bähr M, Hescheler J, Schneider T (2011). Interaction of recombinant and native Cav2.3 E-/R-type voltage-gated Ca2+ channels with the molecular chaperone Hsp70. J Recept, Ligand Channel Res 4, 29-40.

  125. Rappl G, Pabst S, Riemann D, Schmidt A, Wickenhauser C, Schutte W, Hombach AA, Seliger B, Grohe C, and Abken H (2011). Regulatory T cells with reduced repressor capacities are extensively amplified in pulmonary sarcoid lesions and sustain granuloma formation. Clin Immunol 140, 71-83.

  126. Riyahi TY, Frese F, Steinert M, Omosigho NN, Glockner G, Eichinger L, Orabi B, Williams RS, and Noegel AA (2011). RpkA, a Highly Conserved GPCR with a Lipid Kinase Domain, Has a Role in Phagocytosis and Anti-Bacterial Defense. PLoS One 6, e27311.

  127. Rosenbaum S, Kreft S, Etich J, Frie C, Stermann J, Grskovic I, Frey B, Mielenz D, Poschl E, Gaipl U, Paulsson M, and Brachvogel B (2011). Identification of novel binding partners (annexins) for the cell death signal phosphatidylserine and definition of their recognition motif. J Biol Chem 286, 5708-5716.

  128. Sabatelli P, Gara SK, Grumati P, Urciuolo A, Gualandi F, Curci R, Squarzoni S, Zamparelli A, Martoni E, Merlini L, Paulsson M, Bonaldo P, and Wagener R (2011). Expression of the collagen VI alpha5 and alpha6 chains in normal human skin and in skin of patients with collagen VI-related myopathies. J Invest Dermatol 131, 99-107.

  129. Savaskan NE, Seufert S, Hauke J, Tränkle C, Eyüpoglu IY, and Hahnen E. (2011). Dissection of mitogenic and neurodegenerative actions of cystine and glutamate in malignant glioma. Oncogene 30, 43-53.

  130. Schmid F, Glaus E, Barthelmes D, Fliegauf M, Gaspar H, Nurnberg G, Nuernberg P, Omran H, Berger W, and Neidhardt J (2011). U1 snRNA-mediated gene therapeutic correction of splice defects caused by an exceptionally mild BBS mutation. Hum Mutat 32, 815-824.

  131. Schmidt P, and Abken H (2011). The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth. Oncotarget 2, 313-320.

  132. Schmidt P, Kopecky C, Hombach A, Zigrino P, Mauch C, and Abken H (2011). Eradication of melanomas by targeted elimination of a minor subset of tumor cells. Proc Natl Acad Sci U S A 108, 2474-2479.

  133. Schneider M, Lu W, Neumann S, Brachner A, Gotzmann J, Noegel AA, and Karakesisoglou I (2011). Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope. Cell Mol Life Sci 68, 1593-1610.

  134. Schroer N, Pahne J, Walch B, Wickenhauser C, and Smola S (2011). Molecular pathobiology of human cervical high-grade lesions: paracrine STAT3 activation in tumor-instructed myeloid cells drives local MMP-9 expression. Cancer Res 71, 87-97.

  135. Schulte JH, Bachmann HS, Brockmeyer B, DePreter K, Oberthur A, Ackermann S, Kahlert Y, Pajtler K, Theissen J, Westermann F, Vandesompele J, Speleman F, Berthold F, Eggert A, Brors B, Hero B, Schramm A, and Fischer M (2011). High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma. Clin Cancer Res 17, 5082-5092.

  136. Seifert W, Kuhnisch J, Maritzen T, Horn D, Haucke V, and Hennies HC   (2011). Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity. J Biol Chem 286, 37665-37675.

  137. Shina MC, Muller-Taubenberger A, Unal C, Schleicher M, Steinert M, Eichinger L, Muller R, Blau-Wasser R, Glockner G, and Noegel AA (2011). Redundant and unique roles of coronin proteins in Dictyostelium. Cell Mol Life Sci 68, 303-313.

  138. Specht CG, Grunewald N, Pascual O, Rostgaard N, Schwarz G, and Triller A (2011). Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. Embo J 30, 3842-3853.

  139. Stahnke S, Lux K, Uhrig S, Kreppel F, Hosel M, Coutelle O, Ogris M, Hallek M, and Buning H (2011). Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles. Virology 409, 77-83.

  140. Staubach S, and Hanisch FG (2011). Lipid rafts: signaling and sorting platforms of cells and their roles in cancer. Expert Rev Proteomic 8, 263-277.

  141. Stevens KN, Garcia-Closas M, Fredericksen Z, Kosel M, Pankratz VS, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Van 't Veer LJ, Tollenaar RA, Fasching PA, Beckmann MW, Hein A, Ekici AB, Johnson N, Peto J, Dos Santos Silva I, Gibson L, Sawyer E, Tomlinson I, Kerin MJ, Chanock S, Lissowska J, Hunter DJ, Hoover RN, Thomas GD, Milne RL, Perez JA, Gonzalez-Neira A, Benitez J, Burwinkel B, Meindl A, Schmutzler RK, Bartrar CR, Hamann U, Ko YD, Bruning T, Chang-Claude J, Hein R, Wang-Gohrke S, Dork T, Schurmann P, Bremer M, Hillemanns P, Bogdanova N, Zalutsky JV, Rogov YI, Antonenkova N, Lindblom A, Margolin S, Mannermaa A, Kataja V, Kosma VM, Hartikainen J, Chenevix-Trench G, Chen X, Peterlongo P, Bonanni B, Bernard L, Manoukian S, Wang X, Cerhan J, Vachon CM, Olson J, Giles GG, Baglietto L, McLean CA, Severi G, John EM, Miron A, Winqvist R, Pylkas K, Jukkola-Vuorinen A, Grip M, Andrulis I, Knight JA, Glendon G, Mulligan AM, Cox A, Brock IW, Elliott G, Cross SS, Pharoah PP, Dunning AM, Pooley KA, Humphreys MK, Wang J, Kang D, Yoo KY, Noh DY, Sangrajrang S, Gabrieau V, Brennan P, McKay J, Anton-Culver H, Ziogas A, Couch FJ, and Easton DF (2011). Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk. Br J Cancer 105, 1934-1939.

  142. Stoehr O, Hahn J, Moll L, Leeser U, Freude S, Bernard C, Schilbach K, Markl A, Udelhoven M, Krone W, and Schubert M (2011). Insulin receptor substrate-1 and -2 mediate resistance to glucose-induced caspase-3 activation in human neuroblastoma cells. Biochim Biophys Acta 1812, 573-580.

  143. ten Freyhaus H, Dagnell M, Leuchs M, Vantler M, Berghausen EM, Caglayan E, Weissmann N, Dahal BK, Schermuly RT, Ostman A, Kappert K, and Rosenkranz S (2011). Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by Down-Regulation of Protein Tyrosine Phosphatases. Am J Resp Crit Care 183, 1092-1102.

  144. Thadhani R, Kisner T, Hagmann H, Bossung V, Noack S, Schaarschmidt W, Jank A, Kribs A, Cornely OA, Kreyssig C, Hemphill L, Rigby AC, Khedkar S, Lindner TH, Mallmann P, Stepan H, Karumanchi SA, and Benzing T (2011). Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia. Circulation 124, 940-U178.

  145. Tischner D, Theiss J, Karabinskaya A, van den Brandt J, Reichardt SD, Karow U, Herold MJ, Luhder F, Utermoehlen O, and Reichardt HM (2011). Acid Sphingomyelinase Is Required for Protection of Effector Memory T Cells against Glucocorticoid-Induced Cell Death. J Immunol 187, 4509-4516.>

  146. Ukena C, Mahfoud F, Kindermann I, Barth C, Lenski M, Kindermann M, Brandt MC, Hoppe UC, Krum H, Esler M, Sobotka PA, and Bohm M (2011). Cardiorespiratory Response to Exercise After Renal Sympathetic Denervation in Patients With Resistant Hypertension. J Am Coll Cardiol 58, 1176-1182.

  147. Veit G, Zwolanek D, Eckes B, Niland S, Kapyla J, Zweers MC, Ishada-Yamamoto A, Krieg T, Heino J, Eble JA, and Koch M (2011). Collagen XXIII, Novel Ligand for Integrin alpha(2)beta(1) in the Epidermis. Journal of Biological Chemistry 286, 27804-27813.

  148. Vlahou G, Elias M, von Kleist-Retzow JC, Wiesner RJ, and Rivero F (2011). The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum. Eur J Cell Biol 90, 342-355.

  149. Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, and Pasparakis M (2011). Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J Clin Invest 121, 2781-2793.

  150. Volk AE, Carter O, Fricke J, Herkenrath P, Poggenborg J, Borck G, Demant AW, Ivo R, Eysel P, Kubisch C, and Neugebauer A (2011). Horizontal gaze palsy with progressive scoliosis: three novel ROBO3 mutations and descriptions of the phenotypes of four patients. Mol Vis 17, 1978-1986.

  151. von Bargen K, Wohlmann J, Taylor GA, Utermoehlen O, and Haas A (2011). Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron. Infect Immun 79, 2098-2111.

  152. Weber S, Niessen MT, Prox J, Lullmann-Rauch R, Schmitz A, Schwanbeck R, Blobel CP, Jorissen E, de Strooper B, Niessen CM*, and Saftig P (2011). The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development 138, 495-505.

  153. Weber S, Thiele H, Mir S, Toliat MR, Sozeri B, Reutter H, Draaken M, Ludwig M, Altmüller J, Frommolt P, Stuart HM, Ranjzad P, Hanley NA, Jennings R, Newman WG, Wilcox DT, Thiel U, Schlingmann KP, Beetz R, Hoyer PF, Konrad M, Schaefer F, Nürnberg P, Woolf AS (2011). Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like Syndrome. Am J Hum Genet 89, 668-74.

  154. Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernandez-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, and Pasparakis M (2011). FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 477, 330-334.

  155. Wittwer T, Choi YH, Neef K, Schink M, Sabashnikov A, and Wahlers T (2011). Off-pump or Minimized On-pump Coronary Surgery - Initial experience with Circulating Endothelial Cells (CEC) as a supersensitive marker of tissue damage. J Cardiothorac Surg 6, 142.

  156. Wullaert A, Bonnet MC, and Pasparakis M (2011). NF-kappaB in the regulation of epithelial homeostasis and inflammation. Cell Res 21, 146-158.

  157. Xi J, Khalil M, Spitkovsky D, Hannes T, Pfannkuche K, Bloch W, Saric T, Brockmeier K, Hescheler J, and Pillekamp F (2011). Fibroblasts support functional integration of purified embryonic stem cell-derived cardiomyocytes into avital myocardial tissue. Stem Cells Dev 20, 821-830.

  158. Zemva J, and Schubert M (2011). Central insulin and insulin-like growth factor-1 signaling - implications for diabetes associated dementia. Curr Diabetes Rev 7, 356-66.

  159. Zhang ZG, Chometon G, Wen T, Qu H, Mauch C, Krieg T, and Aumailley M (2011). Migration of epithelial cells on laminins: RhoA antagonizes directionally persistent migration. Eur J Cell Biol 90, 1-12.

  160. Zigrino P, Nischt R, and Mauch C (2011). The disintegrin-like and cysteine-rich domains of ADAM-9 mediate interactions between melanoma cells and fibroblasts. J Biol Chem 286, 6801-6807.