Prof. Dr. med. Olaf Utermöhlen - Curriculum Vitae

Education and professional career

since 2013: Professor for Infection Immunology, University of Cologne
2007: Postdoctoral lecturership in Immunology, Medical Faculty, University of Cologne
since 1999: Research group leader, Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne
1999: Postgraduate diploma of molecular biology, University Hamburg
1993 - 1999: Postdoctoral fellow at the Department Tumorvirology, Heinrich-Pette-Institute
1992: MD thesis in immunology, University Hamburg
1991 - 1993: ‘Arzt im Praktikum’ and postdoctoral fellow at the Department Clinical Virology, Heinrich-Pette-Institute, Hamburg
1991 - 1993: Postgraduate study of Molecular Biology at the University Hamburg
1991: State examination human medicine, University Hamburg

Selected publications

Hösel M, Huber A, Bohlen S, Lucifora S, Ronzitti G, Puzzo F, Boisgerault F, Hacker UT, Klöting N, Blüher M, Gluschko A, Schramm M, Utermöhlen O, Bloch W, Mingozzi F, Krut O, Büning H. Autophagy Determines Efficiency of Liver-directed Gene Therapy with Adeno-associated Viral Vectors. Hepatology, 2017 Mar 20. doi: 10.1002/hep.29176. [Epub ahead of print] PMID: 28318036.

Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, Korhonen E, Smura T, Vapalahti O, Papantonis A, Schmidt-Chanasit J, Riparbelli M, Callaini G, Krönke M, Utermöhlen M, Gopalakrishnan J. Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell 2017 20: 397-406.

Brunn A, Mihelcic M, Carstov M, Feind L, Wieser EC, Schmidt J, Utermöhlen O, Deckert M. Toll-Like Receptor 2, Toll-like Receptor 4, Myeloid Differentiation Response Gene 88, and Toll-IL-1 Receptor Domain-Containing Adaptor-inducen Interferon-γ (TRIF) selectively regulate susceptibility of P0106-125-induced murine experimental autoimmune neuritis.  Am J Pathol, 187:42-54. 2017.

Jakobshagen K, Ward B, Baschuk N, Huss S, Brunn A, Malecki M, Fiolka M, Rappl G, Corogeanu D, Karow U, Schiller P, Abken H, Heukamp LC, Deckert M, Krönke M, Utermöhlen O. Endogenous IL-10 alleviates the systemic antiviral cellular immune response and T cell mediated immunopathology
in select organs of acutely LCMV-infected mice. Am J Pathol, 2015, 185: 3025-38.

Erny D, Hrabe de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, Schwierzeck V, Utermöhlen O, Chun E, Garrett WS, McCoy KD, Diefenbach A, Staeheli P, Stecher B, Amit O, Prinz M. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015, 18: 965-77.

Ketscher L, Hannß R, Morales D, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP. Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance. Proc Natl Acad Sci USA. 2015,  12:1577-82.

Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H. BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. EMBO J. 2014, 33: 2171-2187.

Schramm M, Wiegmann K, Schramm S, Utermöhlen O, Krönke M. Riboflavin (vitamin B2) deficiency impairs phagocytic ROS production and defense against Listeria monocytogenes. Eur J Immunol. 2014, 44:728-41.

Ermolaeva MA, Segred A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B. DNA damage in germ cells induces innate immune response triggering systemic stress resistance through enhanced proteostasis. Nature. 2013, 501: 416-20.

Corogeanu D, Willmes R, Wolke M, Plum G, *Utermöhlen O, *Krönke M. Therapeutic concentrations of antibiotics inhibit Shiga toxin release from enterohemorrhagic E. coli O104:H4 from the 2011 German outbreak. BMC Microbiology. 2012, 12: 160-169. *corresponding authors.

Yazdanpanah B, Wiegmann K, Tchikov V, Schramm M, Pongratz C, Kleinridders A, Kashkar H, Utermöhlen O, Krut O, Brüning JC, Schütze S, Krönke M. Riboflavin Kinase couples TNF Receptor 1 to NADPH oxidase. Nature. 2009, 460: 1159-1163.

Herz J, Pardo J, Kashkar H, Schramm M, Bos E, Wiegmann K, Wallich R, Peters PJ, Schmelzer E, Krönke M, Simon MM, Utermöhlen O. Acid Sphingomyelinase is a critical regulator of cytotoxic granule secretion by primary T lymphocytes. Nature Immunology. 2009, 10:761-768.

Ermolaeva MA, Michallet MC, Papadopoulou N, Utermöhlen O, Kranidioti K, Kollias G, Tschopp J, Pasparakis M. Role of TRADD in TNFR1-signaling and in TRIF-dependent inflammatory responses. Nature Immunology. 2008, 9.1037-1046.